全文获取类型
收费全文 | 1297篇 |
免费 | 78篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 82篇 |
妇产科学 | 27篇 |
基础医学 | 242篇 |
口腔科学 | 9篇 |
临床医学 | 108篇 |
内科学 | 369篇 |
皮肤病学 | 21篇 |
神经病学 | 83篇 |
特种医学 | 39篇 |
外国民族医学 | 2篇 |
外科学 | 136篇 |
综合类 | 3篇 |
一般理论 | 2篇 |
预防医学 | 100篇 |
眼科学 | 13篇 |
药学 | 64篇 |
中国医学 | 1篇 |
肿瘤学 | 71篇 |
出版年
2022年 | 9篇 |
2021年 | 28篇 |
2020年 | 16篇 |
2019年 | 40篇 |
2018年 | 33篇 |
2017年 | 19篇 |
2016年 | 21篇 |
2015年 | 29篇 |
2014年 | 32篇 |
2013年 | 50篇 |
2012年 | 47篇 |
2011年 | 70篇 |
2010年 | 30篇 |
2009年 | 45篇 |
2008年 | 72篇 |
2007年 | 65篇 |
2006年 | 43篇 |
2005年 | 64篇 |
2004年 | 49篇 |
2003年 | 34篇 |
2002年 | 50篇 |
2001年 | 51篇 |
2000年 | 65篇 |
1999年 | 37篇 |
1998年 | 14篇 |
1997年 | 12篇 |
1996年 | 7篇 |
1995年 | 9篇 |
1992年 | 29篇 |
1991年 | 25篇 |
1990年 | 21篇 |
1989年 | 27篇 |
1988年 | 20篇 |
1987年 | 29篇 |
1986年 | 11篇 |
1985年 | 15篇 |
1984年 | 15篇 |
1983年 | 12篇 |
1982年 | 7篇 |
1979年 | 9篇 |
1978年 | 6篇 |
1977年 | 7篇 |
1975年 | 5篇 |
1974年 | 10篇 |
1973年 | 12篇 |
1971年 | 7篇 |
1969年 | 11篇 |
1968年 | 5篇 |
1967年 | 6篇 |
1965年 | 5篇 |
排序方式: 共有1376条查询结果,搜索用时 15 毫秒
1.
D. le Nen O. Riot J. F. le Noach P. Caro C. Lefèvre 《Archives of orthopaedic and trauma surgery》1992,111(5):291-292
Summary A distally based posterior calf fasciocutaneous flap was successfully used to reconstruct a major ankle defect with exposed bones and joints. The flap, which reaches easily this region, can also be used as a free flap for coverage of heel and ankle when the forefoot is not involved in the injury. 相似文献
2.
3.
Prolonged increase in serum transaminase activity is usually seen in chronic liver disease. Evaluation in one patient with such a prolonged increase having no evidence of liver disease including histological examination, revealed a limb girdle muscular dystrophy. This case suggests that a muscular disease should be suspected in all children with persistent increase in serum transaminase activity when the liver is apparently normal. 相似文献
4.
Human oocytes isolated from healthy non-preovulatory antralfollicles which had not been stimulated spontaneously resumedmeiosis at a low rate (31%) when compared with those from atreticfollicles (73%). Human follicular fluid did not inhibit spontaneousmaturation of rat oocytes in vitro, regardless of the qualityor maturity of the follicle or the treatment of the patient.In the human, oocyte maturation may involve a stimulatory processas well as a removal of inhibition. 相似文献
5.
B Fedecka-Bruner P Vaigot J Désveaux-Chabrol M Gendreau G Kroemer F Dieterlen-Lièvre 《Developmental immunology》1991,1(3):163-168
Allogeneic immunocompetent T cells injected into chicken embryos induce a graft-versus-host reaction (GVHR) whose most prominent manifestation is splenic hyperplasia. The highly inbred CC and CB strains of chickens used here are, respectively, homozygous for the B4 or B12 MHC haplotypes. By means of a panel of immunological reagents, including alloantisera and monoclonal antibodies against public domains of the T-cell receptor, CD4, CD8, and the inducible interleukin-2-receptor light chain (CD25), it is shown that the bulk of cells in the enlarged spleen are of host origin and do not express markers typical of mature T or B lymphocytes. Among recipient splenocytes, the quantitatively most important population consists of TCR alpha beta-TCR gamma delta- CD4-CD8+CD25+ (TCR0) lymphocytes. Donor cells encountered in the spleen prevalently exhibit a TCR alpha beta+CD4+CD8-CD25+ phenotype and proliferate in vivo. The data demonstrate that nonspecific host and potentially specific donor-derived cellular elements contribute to splenomegaly. 相似文献
6.
Molecular characterization of Cryptosporidium isolates obtained from humans in France 总被引:5,自引:0,他引:5 下载免费PDF全文
Guyot K Follet-Dumoulin A Lelièvre E Sarfati C Rabodonirina M Nevez G Cailliez JC Camus D Dei-Cas E 《Journal of clinical microbiology》2001,39(10):3472-3480
Cryptosporidium parvum is usually considered the agent of human cryptosporidiosis. However, only in the last few years, molecular biology-based methods have allowed the identification of Cryptosporidium species and genotypes, and only a few data are available from France. In the present work, we collected samples of whole feces from 57 patients from France (11 immunocompetent patients, 35 human immunodeficiency virus [HIV]-infected patients, 11 immunocompromised but non-HIV-infected patients) in whom Cryptosporidium oocysts were recognized by clinical laboratories. A fragment of the Cryptosporidium 18S rRNA gene encompassing the hypervariable region was amplified by PCR and sequenced. The results revealed that the majority of the patients were infected with cattle (29 of 57) or human (18 of 57) genotypes of Cryptosporidium parvum. However, a number of immunocompromised patients were infected with C. meleagridis (3 of 57), C. felis (6 of 57), or a new genotype of C. muris (1 of 57). This is the first report of the last three species of Cryptosporidium in humans in France. These results indicate that immunocompromised individuals are susceptible to a wide range of Cryptosporidium species and genotypes. 相似文献
7.
When tracking moving visual stimuli, primates orient their visual axis by combining two kinds of eye movements, smooth pursuit and saccades, that have very different dynamics. Yet, the mechanisms that govern the decision to switch from one type of eye movement to the other are still poorly understood, even though they could bring a significant contribution to the understanding of how the CNS combines different kinds of control strategies to achieve a common motor and sensory goal. In this study, we investigated the oculomotor responses to a large range of different combinations of position error and velocity error during visual tracking of moving stimuli in humans. We found that the oculomotor system uses a prediction of the time at which the eye trajectory will cross the target, defined as the "eye crossing time" (T(XE)). The eye crossing time, which depends on both position error and velocity error, is the criterion used to switch between smooth and saccadic pursuit, i.e., to trigger catch-up saccades. On average, for T(XE) between 40 and 180 ms, no saccade is triggered and target tracking remains purely smooth. Conversely, when T(XE) becomes smaller than 40 ms or larger than 180 ms, a saccade is triggered after a short latency (around 125 ms). 相似文献
8.
Florence Jobard Caroline Lefèvre Aysen Karaduman Claudine Blanchet-Bardon Serap Emre Jean Weissenbach Meral Ozgüc Mark Lathrop Jean-Fran?ois Prud'homme Judith Fischer 《Human molecular genetics》2002,11(1):107-113
We report the identification of mutations in lipoxygenase-3 (ALOXE3) and 12(R)-lipoxygenase (ALOX12B) genes in non-bullous congenital ichthyosiform erythroderma (NCIE) linked to chromosome 17. Linkage disequilibrium analysis of six families affected by NCIE permitted us to reduce a recently reported interval of 8.4 cM on chromosome 17p13.1 to a 600 kb region around the marker D17S1796, which contains LOX genes. LOX products have long been implicated in skin disorders. Two point mutations and one deletion were found in ALOXE3 and three point mutations were found in ALOX12B in these consanguineous families from the Mediterranean basin. ALOXE3 and ALOX12B are two genes which are physically linked and functionally related. They are separated by 38 kb, have one more exon than the other LOX genes and are mainly expressed in epithelial cells including keratinocytes. Although the main substrate(s) of the two enzymes is (are) still unknown, the products of ALOX12B obtained in experimental systems have been demonstrated to be of R-chirality. It seems likely that the product of one of these enzymes may be the substrate of the other, and that they belong to the same metabolic pathway. 相似文献
9.
Marcus Missal Philippe Lefèvre Marc Crommelinck André Roucoux 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1995,106(3):509-512
It is generally accepted that in cats smooth pursuit velocity of the eye never exceeds a few degrees per second. This is in contrast with observations in primates, where smooth pursuit velocity can reach values as high as 100°/s. Cats were trained to fixate and pursue spots of light appearing on a translucent screen. Spots were moved in the horizontal and vertical planes at different constant velocities up to 80°/s. Eye position was recorded with the sclerai search coil technique. Naive cats did not pursue moving targets with high efficiency. Smooth eye movement velocity saturated at 5°/s. After a few days of training, smooth-pursuit eye velocity increased with target velocity and saturated at 25°/s on average. However, velocities twice as high have been observed frequently. When the target was unexpectedly extinguished, smooth eye movement velocity dropped to values close to 0°/s in approximately 350 ms. After a short training period (usually 5 times the same target presentation), the eye continued to move smoothly until the target reappeared. These data suggest that smooth pursuit eye movements of the cat are qualitatively similar to those of primates, but reach lower velocities and are more variable in their characteristics. 相似文献
10.
Sulfonamide resistance in Neisseria meningitidis isolates of clones of the ET-5 complex 总被引:1,自引:0,他引:1
D A Caugant L O Fr?holm R K Selander K B?vre 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》1989,97(5):425-428
A distinctive group of genetically closely related clones, as determined by multilocus enzyme electrophoresis, the ET-5 complex, has been responsible for an epidemic of meningococcal disease in Norway since the mid-1970's. Most isolates of the ET-5 complex from Norway are sulfonamide-resistant, serogroup B, and serotype 15:P1.16. Clones of the ET-5 complex that have been identified as the causative agents of recent outbreaks and epidemics in many other parts of the world show, outside Northern Europe, different associations of serotype protein antigens. We here report the analysis of sulfonamide susceptibility of isolates of the ET-5 complex from various geographic sources. There was no difference in resistance according to geographic source, serogroup, or serotype of the isolates, demonstrating that, in contrast to serotype and serogroup, sulfonamide resistance is an essentially invariant property of clones of the ET-5 complex. 相似文献