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Feldman AM Klein H Tchou P Murali S Hall WJ Mancini D Boehmer J Harvey M Heilman MS Szymkiewicz SJ Moss AJ;WEARIT investigators coordinators;BIROAD investigators coordinators 《Pacing and clinical electrophysiology : PACE》2004,27(1):4-9
The automatic ICD improves survival in patients with a history of sudden cardiac arrest. However, some patients do not meet the guidelines for ICD implantation or are unable to receive an implantable device. This study tested the hypothesis that these patients could benefit from a wearable cardioverter defibrillator. Patients with symptomatic heart failure and an ejection fraction of <0.30 (WEARIT Study) or patients having complications associated with high risk for sudden death after a myocardial infarction or bypass surgery not receiving an ICD for up to 4 months (BIROAD Study) were enrolled into two studies. After a total of 289 patients had been enrolled in the trial (177 in WEARIT and 112 in BIROAD), prespecified safety and effectiveness guidelines had been met. Six (75%) of eight defibrillation attempts were successful. Six inappropriate shock episodes occurred during 901 months of patient use (0.67% unnecessary shocks per month of use). Twelve deaths occurred during the study 6 sudden deaths: 5 not wearing and 1 incorrectly wearing the device). Most patients tolerated the device although 68 patients quit due to comfort issues or adverse reactions.The results of the present study suggest that a wearable defibrillator is beneficial in detecting and effectively treating ventricular tachyarrhythmias in patients at high risk for sudden death who are not clear candidates for an ICD and may be useful as a bridge to transplantation or ICD in some patients. 相似文献
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on behalf of the Cardiovascular Risk Reduction in Early Anaemia Trial with Epoetin Beta investigators coordinators 《Current medical research and opinion》2013,29(11):2543-2552
Abstract
Background and objectives:
This study assessed plasma N-terminal prohormone brain natriuretic peptide (NT-proBNP) as a prognostic marker of cardiovascular risk in patients with chronic kidney disease stages 3–4 and anaemia treated with epoetin beta to two haemoglobin target ranges. 相似文献6.
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