全文获取类型
收费全文 | 1077篇 |
免费 | 46篇 |
国内免费 | 4篇 |
专业分类
耳鼻咽喉 | 6篇 |
儿科学 | 28篇 |
妇产科学 | 9篇 |
基础医学 | 389篇 |
口腔科学 | 18篇 |
临床医学 | 86篇 |
内科学 | 125篇 |
皮肤病学 | 12篇 |
神经病学 | 26篇 |
特种医学 | 111篇 |
外科学 | 55篇 |
综合类 | 21篇 |
预防医学 | 81篇 |
眼科学 | 31篇 |
药学 | 77篇 |
肿瘤学 | 52篇 |
出版年
2021年 | 13篇 |
2018年 | 14篇 |
2015年 | 18篇 |
2014年 | 15篇 |
2013年 | 30篇 |
2012年 | 30篇 |
2011年 | 22篇 |
2010年 | 26篇 |
2009年 | 19篇 |
2008年 | 31篇 |
2007年 | 34篇 |
2006年 | 20篇 |
2005年 | 21篇 |
2004年 | 18篇 |
2003年 | 29篇 |
2002年 | 34篇 |
2001年 | 30篇 |
2000年 | 15篇 |
1999年 | 15篇 |
1998年 | 26篇 |
1997年 | 30篇 |
1996年 | 20篇 |
1995年 | 15篇 |
1994年 | 21篇 |
1993年 | 12篇 |
1990年 | 13篇 |
1989年 | 14篇 |
1988年 | 12篇 |
1986年 | 16篇 |
1981年 | 12篇 |
1980年 | 13篇 |
1973年 | 12篇 |
1941年 | 19篇 |
1940年 | 18篇 |
1938年 | 21篇 |
1937年 | 17篇 |
1936年 | 11篇 |
1934年 | 15篇 |
1933年 | 23篇 |
1932年 | 11篇 |
1931年 | 16篇 |
1930年 | 19篇 |
1929年 | 11篇 |
1928年 | 18篇 |
1927年 | 25篇 |
1926年 | 20篇 |
1925年 | 18篇 |
1924年 | 11篇 |
1923年 | 16篇 |
1922年 | 21篇 |
排序方式: 共有1127条查询结果,搜索用时 15 毫秒
1.
2.
Elevated amounts of platelet-associated serum proteins (PASP) can be detected in idiopathic thrombocytopenic purpura (ITP) and are considered to be of patho-aetiological importance especially in the case of acute ITP, that commonly follows acute febrile illnesses. Using a micro-enzyme-linked immunoassay we examined PASP (IgG, IgM, and C3) in 120 paediatric patients with acute fever caused by viral (n = 45), bacterial (n = 48), or non-detectable agents (n = 27) and compared those values to the levels of PASP of an own paediatric control group (n = 21). Two of the patients presented mild temporary thrombocytopenia without clinical signs in the course of their infectious disease. While having normal platelet counts, the majority of our patients (69.2%) however, showed increased levels of PASP (IgG, IgM, C3; single or combined). Significant differences of PASP levels by discrimination of viral and bacterial diseases could not be demonstrated. Elevated platelet-associated complement was of special interest, because - in the absence of low platelet counts due to platelet-specific antibodies - it must be regarded as an indicator for immune complexes (IC) binding to thrombocyte surface IgG Fc-receptors. Thus we suggest that platelets play a considerable role in the elimination of circulating IC. 相似文献
3.
4.
5.
6.
7.
8.
9.
Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability 总被引:1,自引:15,他引:1
La Spada AR; Peterson KR; Meadows SA; McClain ME; Jeng G; Chmelar RS; Haugen HA; Chen K; Singer MJ; Moore D; Trask BJ; Fischbeck KH; Clegg CH; McKnight GS 《Human molecular genetics》1998,7(6):959-967
X-linked spinal and bulbar muscular atrophy (SBMA) is caused by a CAG
repeat expansion in the first exon of the androgen receptor (AR) gene.
Disease-associated alleles (37-66 CAGs) change in length when transmitted
from parents to offspring, with a significantly greater tendency to shift
size when inherited paternally. As transgenic mice carrying human AR cDNAs
with 45 and 66 CAG repeats do not display repeat instability, we attempted
to model trinucleotide repeat instability by generating transgenic mice
with yeast artificial chromosomes (YACs) carrying AR CAG repeat expansions
in their genomic context. Studies of independent lines of AR YAC transgenic
mice with CAG 45 alleles reveal intergenerational instability at an overall
rate of approximately 10%. We also find that the 45 CAG repeat tracts are
significantly more unstable with maternal transmission and as the
transmitting mother ages. Of all the CAG/CTG repeat transgenic mice
produced to date the AR YAC CAG 45 mice are unstable with the smallest
trinucleotide repeat mutations, suggesting that the length threshold for
repeat instability in the mouse may be lowered by including the appropriate
flanking human DNA sequences. By sequence-tagged site content analysis and
long range mapping we determined that one unstable transgenic line has
integrated an approximately 70 kb segment of the AR locus due to
fragmentation of the AR YAC. Identification of the cis - acting elements
that permit CAG tract instability and the trans -acting factors that
modulate repeat instability in the AR YAC CAG 45 mice may provide insights
into the molecular basis of trinucleotide repeat instability in humans.
相似文献
10.
Ross JL Bellus G Scott CI Abboudi J Grigelioniene G Zinn AR 《American journal of medical genetics. Part A》2003,(1):61-65
We studied two children with combined genetic skeletal disorders. Both had Leri-Weill dyschondrosteosis (LWD); one also had achondroplasia and the other had hypochondroplasia. Both had severe short stature and evidence of rhizomelia and mesomelia as well as other phenotypic features of their individual genetic disorders. Achondroplasia was due to the G380R FGF3R mutation and hypochondroplasia to a N540K mutation in the same gene. The patient with hypochondroplasia had a heterozygous SHOX deletion; no SHOX mutation was identified in the child with achondroplasia. The phenotypes of combined LWD and achondroplasia or hypochondroplasia appeared to be less than additive, suggesting that SHOX and FGFR3 act on overlapping pathways of bone growth and development. 相似文献