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1.
2.
Baha’ N. Noureddin Christiane E. Al-Haddad Ziad Bashshur Bared Safieh-Garabedian 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,244(6):750-752
Background The objective was to measure the plasma concentrations of thymulin and nerve growth factor (NGF) in a group of patients with primary open angle glaucoma (POAG) and compare them with age- and sex-matched normal controls.Methods Twenty-eight patients newly diagnosed with POAG who were not undergoing treatment were compared with the same number of age- and sex-matched healthy controls. Blood samples were drawn into heparinized tubes and plasma samples were collected for the determination of the concentrations of thymulin and NGF, using specific enzyme-linked immunosorbent assay (ELISA). The Student’s t test was used to perform the necessary statistical analysis of the results.Results Seventeen women and 11 men were enrolled in each of the two groups (study and control), with a mean age of 63.7 (SD 10.3) years in the former and 63.3 (SD 9.6) years in the latter. There was a highly significant (p<0.001) elevation in the thymulin levels in POAG patients compared with the control group. However, no significant difference was observed when comparing the plasma NGF levels.Conclusion This is the first report to measure plasma thymulin levels in glaucoma patients. The significant results point the possible role of this immunomodulator in the pathogenesis of primary open angle glaucoma. The potential role of NGF seems to be less likely. These findings warrant further investigation. 相似文献
3.
Beta2-Microglobulin 总被引:1,自引:0,他引:1
Among the uremic toxins in the "middle molecule" range, beta2-microglobulin (β2-M) is certainly one of the most frequently studied compounds. Its serum level increases with the progression of chronic kidney disease, to reach very high concentrations in patients with end-stage kidney disease. It is the major protein component of dialysis-related amyloidosis, a dramatic complication which results from high extracellular concentration and posttranslational modification of β2-M and a number of other promoters of amyloid fibril formation and deposition in osteo-articular tissues. Effective removal of β2-M can be achieved with highly effective hemodialysis and hemodiafiltration techniques but predialysis session serum levels cannot be normalized. The prevalence and severity of β2-M amyloidosis appear to have decreased in the last 20 years, although its occurrence may simply be delayed. 相似文献
4.
Eric Lim Ziad Ali Ayyaz Ali Reza Motalleb-Zadeh Christopher Jackson Seok Ling Ong James Halstead Linda Sharples Jayan Parameshwar John Wallwork Stephen R Large 《The Journal of heart and lung transplantation》2005,24(8):983-989
BACKGROUND: To ascertain survival of ischemic advanced heart failure patients by treatment allocation, we examined the outcome of transplant assessment patients allocated to medical therapy, high-risk conventional surgery, or transplantation. METHODS: Patients were identified from the Papworth transplant database and excluded if primary etiology was not ischemic. Grouping was undertaken according to treatment allocation at initial assessment, and analysis was performed by intention to treat. Survival was computed from the time of assessment and Cox regression used to stratify patients according risk with the Heart Failure Survival Score. RESULTS: From May 1993 to September 2001, a total of 755 patients were admitted for transplant assessment, with 348 (46.1%) identified as having heart failure of ischemic origin. Variables required for calculation of the Heart Failure Survival Score was available in 273 patients (78.4%), and 20 patients (7.3%) were lost to follow-up. Of the remaining 253 patients, 89 (35.2%) were allocated to medical therapy, 32 (12.6%) to surgery, and 132 (52.2%) to transplantation. The relative risk (95% confidence limit) of death compared with medical therapy was 0.62 (0.28, 1.40) for surgery and 0.38 (0.24, 0.61) for transplantation in medium- to high-risk patients. For low-risk patients, the relative risks for death compared with medical therapy were 1.87 (0.63, 5.60) for surgery and 1.97 (0.79, 4.96) for transplantation. CONCLUSIONS: Transplantation improved survival of medium- and high-risk patients compared with medical therapy. In the low-risk group, this was not evident. However, repeated assessment of risk is required because the hazard for death rises steadily after the third year in these patients. 相似文献
5.
6.
Arent S; Mallat M; Westendorp R; van der Woude F; van Es L 《Nephrology, dialysis, transplantation》1997,12(8):1672-1679
Background: The determinators of patient survival
after renal transplantation are incompletely known, and conflicting results
hae been reported. This may have been influenced by time-related changes in
patients selection, post-transplantation management and immunosuppressive
regimens. This study was performed to evaluate in recipients of a first
renal transplant the effect of patient characteristics, transplantation
era, and the immunosuppressive regimen on patient survival.
Method: We studied data from the Leiden Renal
Transplant Database of all first renal transplantations performed between
1966 and 1994 in Leiden, the Netherlands. The effect of the following
parameters on mortality was investigated: era of transplantation, sex, age
at transplantation, cause of renal failure, immunosuppressive regimen, type
and duration of pretransplantation dialysis, hypertension, diabetes
mellitus, and smoking. In addition we analysed the causes of death. Results
were expressed as crude mortality rates, relative risks of mortality, and
standardized mortality ratios as compared with death rates in the Dutch
population. Results: The analysis comprised 86 living
donor transplant recipients and 916 cadaver transplant recipients. After
adjustment for age and sex, the relative risk of morality for living donor
transplant recipients compared with cadaver transplant recipients was 0.5
(95% CI 0.2 to 10.3, P=0.06). In the first cadaver kidney transplant
recipients the risk of first-year mortality improved significantly with
time, which coincided with the introduction of cyclosporin. The risk of
mortality after the first year was higher in patients aged over 40 years at
transplantation, men, smokers, and in the presence of hypertension or
diabetes, but the effect of individual factors on mortality was small. We
found no effect of the type of pretransplantation dialysis or the duration
of pretransplantation haemodialysis on post-transplantation mortality. The
standardized mortality ratio for recipients of first renal transplants was
14 times the population average in the first year after transplantation and
was still four times in the remaining years.
Conclusion: In the present study, time-related changes
in patient management were responsible for improved patient survival in the
first year after transplantation during the study period. Many individual
factors contributed moderately to the risk of mortality after the first
year. Compared to the general population the mortality rate of renal
transplant recipients was significantly higher during the whole follow-up
period. 相似文献
7.
Ognen Ivanovski Thao Nguyen-Khoa Olivier Phan Ziad A Massy 《Nephrology, dialysis, transplantation》2004,19(4):1013-4; author reply 1014
Sir, We read with interest the recent article by Buzello et al. [1]on renal changes in apo E-/- mice after subtotal nephrectomy.They compared renal lesion development in male wild-type C57BL/6mice with that of genetically modified male apo E-/- mice aftereither sham operation, unilateral nephrectomy or subtotal nephrectomy(SNX) by removal of 75% of the cortex in one kidney and removalof the contralateral kidney. They found 相似文献
8.
E Hetier J Ayala P Denèfle A Bousseau P Rouget M Mallat A Prochiantz 《Journal of neuroscience research》1988,21(2-4):391-397
Amoeboid microglial cells (brain macrophages) were purified from early post-natal mouse brain cultures. The percentage of cells stained with an anti-Mac-1 antibody was greater than 95%. Stimulation of these brain macrophages by lipopolysaccharides induced the synthesis of interleukin-1 (IL-1), which, in part, remained associated with the cell surface and, in part, was released into the culture medium. In contrast, pure primary astrocyte cultures and cell lines of transformed or immortalised astrocytes did not synthesise significant amounts of IL-1, demonstrating that amoeboid microglia and not astrocytes synthesise IL-1 in vitro. These physiological data were confirmed by RNA hybridisation studies showing that, on LPS treatment, brain macrophages synthesise significant amounts of IL-1 alpha and IL-1 beta mRNAs. 相似文献
9.
Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. 总被引:6,自引:0,他引:6
John P O'Reardon H Brent Solvason Philip G Janicak Shirlene Sampson Keith E Isenberg Ziad Nahas William M McDonald David Avery Paul B Fitzgerald Colleen Loo Mark A Demitrack Mark S George Harold A Sackeim 《Neuropsychopharmacology》2007,62(11):1208-1216
BACKGROUND: We tested whether transcranial magnetic stimulation (TMS) over the left dorsolateral prefrontal cortex (DLPFC) is effective and safe in the acute treatment of major depression. METHODS: In a double-blind, multisite study, 301 medication-free patients with major depression who had not benefited from prior treatment were randomized to active (n = 155) or sham TMS (n = 146) conditions. Sessions were conducted five times per week with TMS at 10 pulses/sec, 120% of motor threshold, 3000 pulses/session, for 4-6 weeks. Primary outcome was the symptom score change as assessed at week 4 with the Montgomery-Asberg Depression Rating Scale (MADRS). Secondary outcomes included changes on the 17- and 24-item Hamilton Depression Rating Scale (HAMD) and response and remission rates with the MADRS and HAMD. RESULTS: Active TMS was significantly superior to sham TMS on the MADRS at week 4 (with a post hoc correction for inequality in symptom severity between groups at baseline), as well as on the HAMD17 and HAMD24 scales at weeks 4 and 6. Response rates were significantly higher with active TMS on all three scales at weeks 4 and 6. Remission rates were approximately twofold higher with active TMS at week 6 and significant on the MADRS and HAMD24 scales (but not the HAMD17 scale). Active TMS was well tolerated with a low dropout rate for adverse events (4.5%) that were generally mild and limited to transient scalp discomfort or pain. CONCLUSIONS: Transcranial magnetic stimulation was effective in treating major depression with minimal side effects reported. It offers clinicians a novel alternative for the treatment of this disorder. 相似文献
10.