全文获取类型
收费全文 | 614篇 |
免费 | 29篇 |
国内免费 | 6篇 |
专业分类
儿科学 | 36篇 |
妇产科学 | 10篇 |
基础医学 | 77篇 |
口腔科学 | 7篇 |
临床医学 | 52篇 |
内科学 | 140篇 |
皮肤病学 | 6篇 |
神经病学 | 42篇 |
特种医学 | 88篇 |
外科学 | 55篇 |
综合类 | 7篇 |
预防医学 | 37篇 |
眼科学 | 8篇 |
药学 | 55篇 |
中国医学 | 4篇 |
肿瘤学 | 25篇 |
出版年
2022年 | 3篇 |
2021年 | 3篇 |
2020年 | 2篇 |
2019年 | 4篇 |
2018年 | 14篇 |
2017年 | 7篇 |
2016年 | 9篇 |
2015年 | 9篇 |
2014年 | 7篇 |
2013年 | 23篇 |
2012年 | 12篇 |
2011年 | 6篇 |
2010年 | 16篇 |
2009年 | 18篇 |
2008年 | 16篇 |
2007年 | 13篇 |
2006年 | 17篇 |
2005年 | 11篇 |
2004年 | 11篇 |
2003年 | 7篇 |
2002年 | 14篇 |
2001年 | 11篇 |
2000年 | 11篇 |
1999年 | 12篇 |
1998年 | 26篇 |
1997年 | 30篇 |
1996年 | 30篇 |
1995年 | 24篇 |
1994年 | 26篇 |
1993年 | 20篇 |
1992年 | 24篇 |
1991年 | 16篇 |
1990年 | 15篇 |
1989年 | 21篇 |
1988年 | 21篇 |
1987年 | 18篇 |
1986年 | 17篇 |
1985年 | 26篇 |
1984年 | 9篇 |
1983年 | 8篇 |
1982年 | 11篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1979年 | 8篇 |
1978年 | 2篇 |
1977年 | 4篇 |
1976年 | 12篇 |
1975年 | 3篇 |
1974年 | 1篇 |
1929年 | 3篇 |
排序方式: 共有649条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
5.
6.
Van Buskirk Glenn A. González Mario A. Shah Vinod P. Barnhardt Scott Barrett Colin Berge Stephen Cleary Gary Chan Keith Flynn Gordon Foster Thomas Gale Robert Garrison Raymond Gochnour Scott Gotto Amanda Govil Sharad Gray Vivian A. Hammar James Harder Samuel Hoiberg Charles Hussain Ajaz Karp Carol Llanos Hector Mantelle Juan Noonan Patrick Swanson David Zerbe Horst 《Pharmaceutical research》1997,14(7):848-852
Pharmaceutical Research - 相似文献
7.
8.
9.
T Weber T Zerbe C Kaufman A Zeevi R Kormos R Hardesty B Griffith R J Duquesnoy 《Transplantation》1989,48(3):430-435
Endomyocardial biopsies from heart transplant patients were cultured in vitro in the presence of Interleukin-2 and irradiated feeder cells to propagate graft-infiltrating lymphocytes. A correlation was seen between the frequency of lymphocyte growth and the degree of cellular infiltration of the biopsies. In this study, 43 of 113 (38%) histologically negative biopsies obtained from 55 patients during the first month post-transplant yielded lymphocyte cultures. The cumulative incidence of subsequent histological rejection was considerably higher in patients with such "grower" biopsies than in patients with "nongrower" biopsies. In the grower group, we were able to obtain data on alloreactivity of 32 lymphocyte cultures assayed by primed lymphocyte testing (PLT). The presence of donor-specific PLT reactivity in the cultured lymphocytes was associated with an additional risk for subsequent histological rejection. These findings suggest that the in vitro culturing of histologically negative endomyocardial biopsies will identify patients at increased risk for developing heart transplant rejection. 相似文献
10.
Analysis of orthologous gene expression between human pulmonary adenocarcinoma and a carcinogen-induced murine model
下载免费PDF全文
![点击此处可从《The American journal of pathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Stearman RS Dwyer-Nield L Zerbe L Blaine SA Chan Z Bunn PA Johnson GL Hirsch FR Merrick DT Franklin WA Baron AE Keith RL Nemenoff RA Malkinson AM Geraci MW 《The American journal of pathology》2005,167(6):1763-1775
Human adenocarcinoma (AC) is the most frequently diagnosed human lung cancer, and its absolute incidence is increasing dramatically. Compared to human lung AC, the A/J mouse-urethane model exhibits similar histological appearance and molecular changes. We examined the gene expression profiles of human and murine lung tissues (normal or AC) and compared the two species' datasets after aligning approximately 7500 orthologous genes. A list of 409 gene classifiers (P value <0.0001), common to both species (joint classifiers), showed significant, positive correlation in expression levels between the two species. A number of previously reported expression changes were recapitulated in both species, such as changes in glycolytic enzymes and cell-cycle proteins. Unexpectedly, joint classifiers in angiogenesis were uniformly down-regulated in tumor tissues. The eicosanoid pathway enzymes prostacyclin synthase (PGIS) and inducible prostaglandin E(2) synthase (PGES) were joint classifiers that showed opposite effects in lung AC (PGIS down-regulated; PGES up-regulated). Finally, tissue microarrays identified the same protein expression pattern for PGIS and PGES in 108 different non-small cell lung cancer biopsies, and the detection of PGIS had statistically significant prognostic value in patient survival. Thus, the A/J mouse-urethane model reflects significant molecular details of human lung AC, and comparison of changes in orthologous gene expression may provide novel insights into lung carcinogenesis. 相似文献