全文获取类型
收费全文 | 56594篇 |
免费 | 6123篇 |
国内免费 | 4135篇 |
专业分类
耳鼻咽喉 | 435篇 |
儿科学 | 653篇 |
妇产科学 | 563篇 |
基础医学 | 6280篇 |
口腔科学 | 1092篇 |
临床医学 | 7696篇 |
内科学 | 7805篇 |
皮肤病学 | 600篇 |
神经病学 | 2589篇 |
特种医学 | 2098篇 |
外国民族医学 | 34篇 |
外科学 | 5484篇 |
综合类 | 10248篇 |
现状与发展 | 19篇 |
一般理论 | 7篇 |
预防医学 | 4308篇 |
眼科学 | 1452篇 |
药学 | 6424篇 |
68篇 | |
中国医学 | 4250篇 |
肿瘤学 | 4747篇 |
出版年
2024年 | 330篇 |
2023年 | 1182篇 |
2022年 | 2929篇 |
2021年 | 3679篇 |
2020年 | 2793篇 |
2019年 | 2053篇 |
2018年 | 2172篇 |
2017年 | 2055篇 |
2016年 | 1830篇 |
2015年 | 2821篇 |
2014年 | 3366篇 |
2013年 | 2984篇 |
2012年 | 4386篇 |
2011年 | 4654篇 |
2010年 | 3061篇 |
2009年 | 2405篇 |
2008年 | 2912篇 |
2007年 | 2949篇 |
2006年 | 2741篇 |
2005年 | 2627篇 |
2004年 | 1697篇 |
2003年 | 1714篇 |
2002年 | 1463篇 |
2001年 | 1228篇 |
2000年 | 1041篇 |
1999年 | 1026篇 |
1998年 | 712篇 |
1997年 | 645篇 |
1996年 | 526篇 |
1995年 | 468篇 |
1994年 | 374篇 |
1993年 | 222篇 |
1992年 | 322篇 |
1991年 | 232篇 |
1990年 | 231篇 |
1989年 | 184篇 |
1988年 | 206篇 |
1987年 | 143篇 |
1986年 | 127篇 |
1985年 | 91篇 |
1984年 | 59篇 |
1983年 | 45篇 |
1982年 | 34篇 |
1981年 | 26篇 |
1980年 | 13篇 |
1979年 | 34篇 |
1978年 | 11篇 |
1977年 | 6篇 |
1974年 | 6篇 |
1969年 | 5篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
Ecotoxicology - Soil heavy metal pollution evaluations are a necessary measure for mine ecological control projects. In this study, the heavy metals Pb, Zn and Cd were studied in mining areas,... 相似文献
2.
3.
社会力量具备相应的经济基础和技术条件,对于公立互联网医院体系建设具有积极的促进作用。但是实践中仍然存在商业模式不完善、监管制度不健全等问题。基于经济学契约理论要义,提出在坚持激励与约束机制并举、平衡公私益关系的前提下,通过完善医保政策、构建互联网医疗服务价格分类管理机制来促进社会力量向医疗服务公益性目标回归,并通过构建完善的监督体制来约束部分社会力量的盲目逐利性行为。 相似文献
4.
Wuteng Cao Huabin Hu Jiao Li Qianyu Wu Lishuo Shi Biao Li Jie Zhou Xinhua Wang Junhong Chen Chao Wang Huaiming Wang Weihao Deng Yan Huang Yanhong Deng 《International journal of cancer. Journal international du cancer》2023,153(11):1894-1903
Neoadjuvant programmed cell death protein 1 (PD-1) blockade exhibits promising efficacy in patients with mismatch repair deficient (dMMR) colorectal cancer (CRC). However, discrepancies between radiological and histological findings have been reported in the PICC phase II trial (NCT 03926338). Therefore, we strived to discern radiological features associated with pathological complete response (pCR) based on computed tomography (CT) images. Data were obtained from the PICC trial that included 36 tumors from 34 locally advanced dMMR CRC patients, who received neoadjuvant PD-1 blockade for 3 months. Among the 36 tumors, 28 (77.8%) tumors achieved pCR. There were no statistically significant differences in tumor longitudinal diameter, the percentage change in tumor longitudinal diameter from baseline, primary tumor sidedness, clinical stage, extramural venous invasion status, intratumoral calcification, peritumoral fat infiltration, intestinal fistula and tumor necrosis between the pCR and non-pCR tumors. Otherwise, tumors with pCR had smaller posttreatment tumor maximum thickness (median: 10 mm vs 13 mm, P = .004) and higher percentage decrease in tumor maximum thickness from baseline (52.9% vs 21.6%, P = .005) compared to non-pCR tumors. Additionally, a higher proportion of the absence of vascular sign (P = .003, odds ratio [OR] = 25.870 [95% CI, 1.357-493.110]), nodular sign (P < .001, OR = 189.000 [95% CI, 10.464-3413.803]) and extramural enhancement sign (P = .003, OR = 21.667 [2.848-164.830]) was observed in tumors with pCR. In conclusion, these CT-defined radiological features may have the potential to serve as valuable tools for clinicians in identifying patients who have achieved pCR after neoadjuvant PD-1 blockade, particularly in individuals who are willing to adopt a watch-and-wait strategy. 相似文献
5.
Sophocarpine attenuates toll‐like receptor 4 in steatotic hepatocytes to suppress pro‐inflammatory cytokines synthesis 下载免费PDF全文
6.
7.
Richard Kim Elaine Tan Emily Wang Amit Mahipal Dung-Tsa Chen Biwei Cao Fadzai Masawi Cindy Machado James Yu Dae Won Kim 《The oncologist》2020,25(12):e1893-e1899
Lessons Learned
- The combination of trametinib and sorafenib has an acceptable safety profile, albeit at doses lower than approved for monotherapy.
- Maximum tolerated dose is trametinib 1.5 mg daily and sorafenib 200 mg twice daily.
- The limited anticancer activity observed in this unselected patient population does not support further exploration of trametinib plus sorafenib in patients with hepatocellular carcinoma.
8.
9.
Shengxuan Cao Chen Wang Xin Ma Xu Wang Jiazhang Huang Chao Zhang Li Chen Xiang Geng Kan Wang 《Journal of orthopaedic research》2019,37(8):1860-1867
Patients with mechanic ankle instability experience increased tibiotalar and subtalar joint laxity. However, in vivo joint kinematics in functional ankle instability (FAI) patients and lateral ankle sprain (LAS) copers, especially during dynamic activities, are poorly understood. Ten FAI patients, 10 LAS copers, and 10 healthy controls were included in this study. A dual fluoroscopic imaging system was used to analyze the tibiotalar and subtalar joint kinematics during stair descent. Five key poses of stair descent were analyzed. Kinematic data from six degrees of freedom were calculated utilizing a solid modeling software. The range of motion and joint positions in each degree of freedom were compared among the three groups. The tibiotalar joints of FAI patients and LAS copers were significantly more inverted than those of healthy controls during the foot strike (p = 0.016, = 0.264). The subtalar joints of FAI patients were significantly more anteriorly translated (pose 2, p = 0.003, = 0.352; pose 3, p < 0.001, = 0.454; pose 4, p = 0.004, = 0.334), inverted (pose 4, p = 0.027, = 0.234; pose 5,p = 0.034, = 0.221), and externally rotated (pose 4, p = 0.037, = 0.217; pose 5; p = 0.004, = 0.331) than those of healthy controls during the mid‐stance and the heel off. The FAI patients showed excessive tibiotalar inversion and subtalar joint hypermobility during stair descent. Meanwhile, the LAS copers maintained subtalar joint stability, and only showed excessive tibiotalar inversion in foot strike. These data provide insight into the mechanisms behind the development of FAI after initial LAS. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1860–1867, 2019 相似文献
10.