全文获取类型
收费全文 | 2244篇 |
免费 | 162篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 26篇 |
儿科学 | 71篇 |
妇产科学 | 46篇 |
基础医学 | 388篇 |
口腔科学 | 196篇 |
临床医学 | 194篇 |
内科学 | 404篇 |
皮肤病学 | 44篇 |
神经病学 | 116篇 |
特种医学 | 106篇 |
外科学 | 257篇 |
综合类 | 15篇 |
预防医学 | 110篇 |
眼科学 | 49篇 |
药学 | 214篇 |
中国医学 | 4篇 |
肿瘤学 | 176篇 |
出版年
2023年 | 16篇 |
2022年 | 27篇 |
2021年 | 39篇 |
2020年 | 25篇 |
2019年 | 25篇 |
2018年 | 48篇 |
2017年 | 30篇 |
2016年 | 47篇 |
2015年 | 45篇 |
2014年 | 55篇 |
2013年 | 61篇 |
2012年 | 119篇 |
2011年 | 133篇 |
2010年 | 73篇 |
2009年 | 53篇 |
2008年 | 116篇 |
2007年 | 118篇 |
2006年 | 113篇 |
2005年 | 124篇 |
2004年 | 124篇 |
2003年 | 108篇 |
2002年 | 91篇 |
2001年 | 71篇 |
2000年 | 57篇 |
1999年 | 60篇 |
1998年 | 22篇 |
1997年 | 23篇 |
1996年 | 23篇 |
1995年 | 17篇 |
1994年 | 15篇 |
1993年 | 13篇 |
1992年 | 38篇 |
1991年 | 42篇 |
1990年 | 42篇 |
1989年 | 52篇 |
1988年 | 45篇 |
1987年 | 43篇 |
1986年 | 44篇 |
1985年 | 36篇 |
1984年 | 21篇 |
1983年 | 16篇 |
1982年 | 13篇 |
1979年 | 14篇 |
1978年 | 10篇 |
1977年 | 13篇 |
1973年 | 9篇 |
1971年 | 10篇 |
1969年 | 8篇 |
1968年 | 11篇 |
1967年 | 8篇 |
排序方式: 共有2416条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
Yoshie Ochiai Kazuhiro Kurisu Takashi Kajiwara Hiroshi Kumeda Ryuji Tominaga 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(2):81-83
We describe a case of type B aortic dissection with large ascending aortic aneurysm occurring 12.8 years after aortic root
replacement (Cabrol procedure) in a non-Marfan patient with cystic medial necrosis of the aorta. We have successfully performed
an extended total aortic arch replacement using a four-branched graft through the “L-indsion” approach (a combination of a
left anterior thoracotomy and upper half median sternotomy). Of note, a histological specimen from the aneurysmal ascending
aortic wall revealed “healed aortic dissection” with fibrous tissue replacing the media and intima in addition to multiple
foci of cystic medial necrosis. 相似文献
5.
6.
7.
Yoko Saeki Adachi Toshiko Itazawa Motokazu Nakabayashi Tatsuya Fuchizawa Yoshie Okabe Yasunori Ito Yuichi Adachi Gyokei Murakami Toshio Miyawaki 《Allergology international》2006,55(2):167-171
BACKGROUND: A new electronic mesh nebulizer, eMotion is known to have higher performance compared to conventional nebulizers. However, there are some concerns about whether too much delivered dose might cause side effects with higher frequency. METHODS: To evaluate the safety and usefulness of the nebulizer, we measured changes in heart rates and lung functions of 73 asthmatic children when they inhaled 1 microg/kg of procaterol with eMotion or a conventional nebulizer, Junior BOY. RESULTS: In 34 children with mild asthma exacerbation, physical findings, lung function and transcutaneous oxygen saturation levels were improved after inhalation using both nebulizers. No adverse effects including significant increase of heart rate were found. Improvements in the rates of the parameters were comparable. When response to beta2-agonist inhalation was checked in 39 children in stable condition, similar degrees of improvement in lung function were observed, and heart rates did not change after inhalation with either nebulizers. CONCLUSIONS: Safety and efficacy was comparable between eMotion and a conventional nebulizer when it was used to administer beta2-agonists in asthmatic children. However, from the fact that eMotion needs only 3-4 minutes to inhale 2 mL solution, eMotion could be more useful for most children who usually do not prefer longer inhalation time with conventional compressor nebulizers. 相似文献
8.
Shibahara Hiroaki; Shigeta Minoru; Inoue Miyuki; Hasegawa Akiko; Koyama Koji; Alexander Nancy J.; Isojima Sinzo 《Human reproduction (Oxford, England)》1996,11(12):2595-2599
The blocking effects of complement-dependent sperm immobilizingantibodies in the sera of infertile women and monoclonal antispermantibodies against humans and mice on fertilization were investigated.The hemizona assay (HZA) and sperm penetration assay (SPA) wereused to study the inhibitory effects of sera from 22 infertilepatients positive for sperm immobilizing antibodies. Use ofthese tests allowed us to differentiate whether the antibodyblocked spermzona pellucida tight binding and/or spermpenetration into the ooplasm. The zona pellucida penetrationassay (ZPA) was also used to study the effects of four monoclonalantibodies (mAbs) on human sperm penetration into the zona pellucida.Seven mAbs against murine spermatozoa were tested for theirinhibitory effects on in-vitro fertilization (IVF) and HZA inmice. Of 22 patient sera with sperm immobilizing antibodies,21 (95.5%) inhibited HZA attachment and penetration, whereasthis did not occur in any of 13 patient sera without these antibodies.However, 19 of 22 (86.4%) patient sera with sperm immobilizingantibodies and eight of 13 (61.5%) patient sera without theseantibodies inhibited the SPA. Two (2C6, 1G12) of four mAbs againsthuman spermatozoa showed strong inhibitory effects in all theassays (HZA, ZPA and SPA). One mAb (3B10) did not inhibit HZAbut blocked ZPA and SPA. Another mAb (H6-3C4) seemed to haveno inhibitory effects on fertilization. Two (Vx 5 and Vx 8)of seven mAbs against murine spermatozoa inhibited IVF in micebut did not block mouse HZA. These findings suggest that antispermantibodies block fertilization at specific stages. Some of themmay inhibit sperm capacitation and thus prevent all processesof fertilization that follow. Some other antibodies may notaffect capacitation and sperm binding to zona pellucida butinhibit the acrosome reaction, followed by the blocking of spermpenetration through zona pellucida and ooplasm. 相似文献
9.
Focal hyperplasia of intracytoplasmic filaments of 100A in diameter was observed within chief cells of the parathyroid gland in dogs treated with nalidixic acid. The structure, as a rule, was located in the neighborhood of the nucleus and no other cell organelles were detected within it. Its size had a wide spectrum from a small part of the cytoplasm to as large as half a cell. Golgi apparatus and rough endoplasmic reticulum in the involved cells had a tendency to atrophy. These cells occasionally contained less secretory granules. Lipid droplets are diffusely increased. The pathogenesis and significance of the present intracytoplasmic filaments remain to be determined. However, as lipid deposition, atrophy of Golgi apparatus, poorly developed rough endoplasmic reticulum occur in a hypofunctional or degenerative state, it might be possible that filamentous hyperplasia is closely associated with that state. 相似文献
10.
M. Baba K. Konno S. Shigeta E. De Clercq 《European journal of clinical microbiology & infectious diseases》1987,6(2):158-160
The highly potent and selective anti-DNA virus agent (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA] was found to inhibit in vitro the replication of a number of clinical varicella-zoster virus strains within the concentration range of 0.63—5.7 ng/ml. With a mean 50 % inhibitory concentration of 1.8 ng/ml and selectivity index of 29000, (S)-HPMPA is one of the most potent and most selective varicella-zoster virus inhibitors discovered to date. 相似文献