全文获取类型
收费全文 | 3557篇 |
免费 | 286篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 17篇 |
儿科学 | 86篇 |
妇产科学 | 22篇 |
基础医学 | 568篇 |
口腔科学 | 24篇 |
临床医学 | 330篇 |
内科学 | 959篇 |
皮肤病学 | 30篇 |
神经病学 | 350篇 |
特种医学 | 179篇 |
外科学 | 383篇 |
综合类 | 94篇 |
预防医学 | 270篇 |
眼科学 | 26篇 |
药学 | 225篇 |
中国医学 | 9篇 |
肿瘤学 | 280篇 |
出版年
2022年 | 35篇 |
2021年 | 39篇 |
2020年 | 36篇 |
2019年 | 38篇 |
2018年 | 56篇 |
2017年 | 38篇 |
2016年 | 57篇 |
2015年 | 70篇 |
2014年 | 73篇 |
2013年 | 118篇 |
2012年 | 164篇 |
2011年 | 176篇 |
2010年 | 131篇 |
2009年 | 93篇 |
2008年 | 150篇 |
2007年 | 171篇 |
2006年 | 167篇 |
2005年 | 173篇 |
2004年 | 147篇 |
2003年 | 120篇 |
2002年 | 148篇 |
2001年 | 127篇 |
2000年 | 166篇 |
1999年 | 138篇 |
1998年 | 87篇 |
1997年 | 67篇 |
1996年 | 53篇 |
1995年 | 36篇 |
1994年 | 43篇 |
1993年 | 40篇 |
1992年 | 51篇 |
1991年 | 43篇 |
1990年 | 51篇 |
1989年 | 75篇 |
1988年 | 55篇 |
1987年 | 59篇 |
1986年 | 56篇 |
1985年 | 45篇 |
1984年 | 36篇 |
1983年 | 26篇 |
1982年 | 20篇 |
1978年 | 22篇 |
1977年 | 19篇 |
1975年 | 19篇 |
1974年 | 23篇 |
1973年 | 19篇 |
1972年 | 23篇 |
1971年 | 33篇 |
1969年 | 20篇 |
1968年 | 21篇 |
排序方式: 共有3852条查询结果,搜索用时 15 毫秒
1.
2.
M. H. Wernitz S. Swidsinski K. Weist D. Sohr W. Witte K-P. Franke D. Roloff H. Rüden S. K. Veit 《Clinical microbiology and infection》2005,11(6):457-465
Screening of potential MRSA-positive patients at hospital admission is recommended in German and international guidelines. This policy has been shown to be effective in reducing the frequency of nosocomial MRSA transmissions in the event of an outbreak, but the influence of screening on reducing hospital-acquired MRSA infections in a hospital setting where MRSA is endemic is not yet well-documented. This study describes the effect of hospital-wide screening of defined risk groups in a 700-bed acute care hospital during a period of 19 months. In a cohort study with a 19-month control period, the frequencies of hospital-acquired MRSA infections were compared with and without screening. In the control period, there were 119 MRSA-positive patients, of whom 48 had a hospital-acquired MRSA infection. On the basis of this frequency, a predicted total of 73.2 hospital-acquired MRSA infections was calculated for the screening period, but only 52% of the expected number (38 hospital-acquired MRSA infections) were observed, i.e., 48% of the predicted number of hospital-acquired MRSA infections were prevented by the screening programme. The screening programme was performed with minimal effort and can therefore be recommended as an effective measure to help prevent hospital-acquired MRSA infections. 相似文献
3.
The purpose of this study is to show the spectrum of adjacent organ invasion and to make a brief review of hepatic alveolar hydatid disease (AHD), using CT and MR imaging. We retrospectively reviewed CT and MR images of three patients with various adjacent organ invasions surgically and histologically proven to be AHD. Local invasion to right kidney and adrenal, right hemidiaphragm and lung were detected in one patient, right adrenal in another patient and gall bladder, duodenum, gastric wall and pancreas invasion in the other. AHD may rarely extend to the gall bladder, stomach, duodenum, pancreas, right adrenal and kidney, diaphragm, pleura and lung. The extension of the disease outside the liver is usually encountered in patients with large, peripherally located masses in the advanced stage of the disease. 相似文献
4.
5.
6.
7.
8.
David G Witte Michael E Brune Sweta P Katwala Ivan Milicic Deanne Stolarik Yu-Hua Hui Kennan C Marsh James F Kerwin Michael D Meyer Arthur A Hancock 《The Journal of pharmacology and experimental therapeutics》2002,300(2):495-504
Fiduxosin is a new alpha(1)-adrenoceptor antagonist targeted for the treatment of symptomatic benign prostatic hyperplasia. The purpose of this study was to determine and compare the potencies of the alpha(1)-adrenoceptor antagonists terazosin, doxazosin, tamsulosin, and fiduxosin, based on relationships between plasma drug concentrations and blockade of phenylephrine (PE)-induced intraurethral (IUP) and mean arterial pressure (MAP) responses after single oral dosing in conscious male beagle dogs. Magnitude of blockade and plasma concentrations were evaluated at selected time points over 24 h. All drugs produced dose-dependent antagonism of PE-induced IUP and MAP responses. When IUP and MAP blockade effects were plotted against drug plasma concentrations, direct relationships were observed that were well described by the sigmoidal maximal effect model. IUP IC(50) values for terazosin, doxazosin, tamsulosin, and fiduxosin were 48.6, 48.7, 0.42, and 261 ng/ml, respectively. MAP IC(50) values were 12.2, 13.8, 1.07, and 1904 ng/ml, respectively. Uroselectivity index values, defined as MAP IC(50)/IUP IC(50), were 0.25, 0.28, 2.6, and 7.3, respectively. These results extend previous observations with terazosin in this model, showing that doxazosin exhibits a uroselectivity index comparable to terazosin, consistent with the lack of alpha(1)-adrenoceptor subtype selectivity or uroselectivity of these drugs. Tamsulosin, an alpha(1a)-/alpha(1d)-subtype selective agent, had an index value approximately 10-fold greater than the nonselective drugs. Based on its pharmacokinetic profile and a relative uroselectivity 29-fold greater than the nonselective drugs, fiduxosin is expected to exhibit greater selectivity for urethral compared with vascular alpha(1)-adrenoceptors in human and should be a novel, long-acting, uroselective alpha(1)-adrenoceptor antagonist. 相似文献
9.
John S. Witte Giske Ursin Jack Siemiatycki W. Douglas Thompson Annali Paganini-Hill Robert W. Haile 《Breast cancer research and treatment》1997,42(3):243-251
We investigated associations between diet and premenopausal bilateral breast cancer in a familial matched case-control study. We studied 140 cases from population-based registries in Los Angeles County (California) and Connecticut, and from the major hospitals in the southern parts of the Province of Quebec. Unaffected sisters of the cases served as matched controls (222 total). Dietary intake were assessed with a food frequency questionnaire. Total fat, monounsaturated fat, polyunsaturated fat, oleic acid, and linoleic acid intake was inversely associated with premenopausal bilateral breast cancer risk. Consumption of carbohydrates (and sweetened beverages) was associated with an increased risk. We observed no associations for dietary fiber, antioxidants, or major food groupings, but we did observe inverse associations for intake of low fat dairy products and tofu. These findings suggest that monounsaturated and polyunsaturated fats, as well as soy foods, might reduce the risk of premenopausal bilateral breast cancer. 相似文献
10.
Die 5-Jahres-überlebensrate von differenzierten Schilddrüsenkarzinomen ist generell sehr gut und betr?gt 80 – 95%. Hierbei
bestehen Abh?ngigkeiten zum Alter des Patienten [15], zum prim?ren Tumorstadium, zur histologischen Differenzierung und zum
Ausma? der region?ren und Fernmetastasierung [6]. Patienten mit Tumorfreiheit haben ebenfalls eine bessere Prognose gegenüber
denen mit einem Resttumor. Dies spricht für ein konsequentes Vorgehen beim Prim?reingriff mit Thyreoidektomie und Entfernung
der Lymphknoten des zentralen Kompartments. Stadienadaptiert schlie?t sich eine Radiojodtherapie oder die Kombination mit
einer externen Radiatio an.
Bei der Reoperation differenzierter Schilddrüsenkarzinome mu? zwischen der individuellen Prognose des Patienten, dem Ziel
der Operation und der postoperativen Morbidit?t/Mortalit?t entschieden werden. Aufgrund des hohen Risikos sollten diese Operationen
in Zentren durchgeführt werden, so da? postoperative Komplikationen (permanente Recurrensparese/Hypoparathyreoidismus) vertretbar
gering gehalten werden k?nnen (Tabelle 11).
Dennoch sollte nicht au?er Acht gelassen werden, da? individuell bei differenzierten Schilddrüsenkarzinomen im Stadium pT1
auch ein eingeschr?nkt radikales Vorgehen (Hemithyreoidektomie) ohne Verschlechterung der Prognose m?glich scheint. Strenge
Nachuntersuchungsergebnisse und Ergebnisse weiterer klinischer Studien müssen hierzu abgewartet werden. 相似文献