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1.
Kristanto Yuli Yarso Muhammad David Perdana Putra Monica Bellynda Akhmad Azmiardi 《Asian Pacific journal of cancer prevention》2021,22(11):3615
Objective:This study aimed to compare the patients’ satisfaction level after fibroadenoma surgery with Video-Assisted Breast Surgery (VABS) and Vacuum-Assisted Breast Biopsy (VABB) techniques. Methods:Patients who underwent VABS or VABB for a diagnosis of fibroadenoma mammae at the Oncology Clinic in Solo, Indonesia were included in this study. Clinical and demographic data were obtained from medical records. Direct or telephone interviews were performed and the patients were asked to complete Universitas Sebelas Maret Breast Satisfaction Questionnaire 8 (UNS-BsQ8) questionnaire. Results:A total sample of 16 patients with VABS and 26 patients with VABB were recruited. All the patients were confirmed to have fibroadenoma based on the pathological result. The mean total scores for VABS and VABB were 34.50 ± 2.094 and 31.57 ± 3.081, respectively (P= 0.137). Out of 8 questions, only 3 items had statistically significant differences. VABS had higher mean score than VABB in terms of surgery cost (P = 0.002), pain in surgery site (P = 0.006), and pain in shoulder (P = 0.013). Conclusion:There was no significant difference in terms of overall patients’ satisfaction level between both groups. However, VABS had a higher mean score than VABB in terms of cost and pain.Key Words: Video-assisted breast surgery, vacuum-assisted breast biopsy, minimally invasive breast surgery 相似文献
2.
Wisnumurti Kristanto Peter M. van Ooijen Riksta Dikkers Marcel J. Greuter Felix Zijlstra Matthijs Oudkerk 《The international journal of cardiovascular imaging》2010,26(1):77-87
Multi detector-row CT (MDCT), the current preferred method for coronary artery disease assessment, is still affected by motion
artefacts. To rule out motion artefacts, qualitative image analysis is usually performed. Our study aimed to develop a quantitative
image analysis for motion artefacts detection as an added value to the qualitative analysis. An anthropomorphic moving heart
phantom with adjustable heart-rate was scanned on 64-MDCT and dual-source-CT. A new software technique was developed which
detected motion artefacts in the coronaries and also in the myocardium, where motion artefacts are more apparent; with direct
association to the qualitative analysis. The new quantitative analysis managed to detect motion artefacts in phantom scans
and relate them to artefact-induced vessel stenoses. Quantifying these artefacts at corresponding locations in the myocardium,
artefact-induced vessel stenosis findings could be avoided. In conclusion, the quantitative analysis together with the qualitative
analysis rules out artefact-induced stenosis. 相似文献
3.
Vriesendorp R Cohen A Kristanto P Vrijens B Rakesh P Anand B Iwebor HU Stiekema J 《European journal of clinical pharmacology》2007,63(12):1115-1121
Aims
This pilot study was designed to evaluate the feasibility and benefits of electronic adherence monitoring of antiretroviral medications in HIV patients who recently started Highly Active Anti Retroviral Therapy (HAART) in Francistown, Botswana and to compare this with self-reporting.Methods
Dosing histories were compiled electronically using Micro Electro Mechanical Systems (MEMS) monitors to evaluate adherence to prescribed therapies. Thirty patients enrolled in the antiretroviral treatment program were monitored over 6 weeks. These patients were all antiretroviral (ARV) naïve. After each visit (mean three times) to the pharmacy, the data compiled by the monitors were downloaded. Electronic monitoring of adherence was compared to patient self-reports of adherence.Results
The mean individual medication adherence level measured with the electronic device was 85% (range 21–100%). The mean adherence level measured by means of self-reporting was 98% (range 70–100%). Medication prescribed on a once-a-day dose base was associated with a higher adherence level (97.9% for efavirenz) compared with a twice-a-day regimen (88.4% for Lamivudine/Zidovudine).Conclusions
It is feasible to assess treatment adherence of patients living in a low resource setting on HAART by using electronic monitors. Adherence, even in the early stages of treatment, appears to be insufficient in some patients and may be below the level required for continuous inhibition of viral replication. This approach may lead to improved targeting of counselling about their medication intake of such patients in order to prevent occurrence of resistant viral strains due to inadequate inhibition of viral replication. In this pilot study a significant difference between the data recorded through the electronic monitors and those provided by self-reporting was observed.4.
Ai‐Ping Chua Chieh‐Yang Koo William Kristanto Maria Victoria Jane Macalalag Parot Eugene Siang‐Joo Tan Esther Hui‐Ting Koh Munirah Binte Abd Gani Pipin Kojodjojo Tun‐Oo Han Siew‐Pang Chan Jenny Pek‐Ching Chong Christopher Frampton Arthur Mark Richards Chi‐Hang Lee 《Clinical cardiology》2018,41(6):721-728
Obstructive sleep apnea (OSA) is an emerging risk marker for acute coronary syndrome (ACS). This randomized trial aims to determine the effects of sleep study–guided multidisciplinary therapy (SGMT) comprising overnight sleep study, continuous positive airway pressure, and behavioral therapy for OSA during the subacute phase of ACS. We hypothesize that SGMT will reduce (1) the plasma levels of N‐terminal pro brain natriuretic peptide and suppression of tumorigenicity 2; (2) the estimated 10‐year risk of cardiovascular mortality as measured by the European Systematic Coronary Risk Evaluation (SCORE) algorithm; and (3) the cardiovascular event rate during a 3‐year follow‐up, compared with standard therapy. In the SGMT trial, 180 patients presenting with ACS will be randomly assigned to SGMT (n = 90) and standard therapy (n = 90) groups. Both groups will receive guideline‐mandated treatment for ACS. Those assigned to SGMT will additionally undergo a sleep study and, if OSA is diagnosed, attend a multidisciplinary OSA clinic where they will receive personalized treatment including continuous positive airway pressure and behavioral/lifestyle counseling. The primary endpoint is the plasma N‐terminal pro brain natriuretic peptide concentration at 7‐month follow‐up. This report presents the baseline characteristics of 117 patients (SGMT group: n =54; standard therapy group: n =63) who had been enrolled into the study as of August 31, 2017. The results of this trial will help us to understand whether active OSA diagnosis and treatment will improve the physiologic and clinical cardiovascular outcomes of this group of patients. 相似文献
5.
Pinar Yilmaz Karel Wallecan Wisnumurti Kristanto Jean-Paul Aben Adriaan Moelker 《Journal of digital imaging》2018,31(5):670-679
The purpose of this study was to evaluate a semi-automatic right ventricle segmentation method on short-axis cardiac cine MR images which segment all right ventricle contours in a cardiac phase using one seed contour. Twenty-eight consecutive short-axis, four-chamber, and tricuspid valve view cardiac cine MRI examinations of healthy volunteers were used. Two independent observers performed the manual and automatic segmentations of the right ventricles. Analyses were based on the ventricular volume and ejection fraction of the right heart chamber. Reproducibility of the manual and semi-automatic segmentations was assessed using intra- and inter-observer variability. Validity of the semi-automatic segmentations was analyzed with reference to the manual segmentations. The inter- and intra-observer variability of manual segmentations were between 0.8 and 3.2%. The semi-automatic segmentations were highly correlated with the manual segmentations (R2 0.79–0.98), with median difference of 0.9–4.8% and of 3.3% for volume and ejection fraction parameters, respectively. In comparison to the manual segmentation, the semi-automatic segmentation produced contours with median dice metrics of 0.95 and 0.87 and median Hausdorff distance of 5.05 and 7.35 mm for contours at end-diastolic and end-systolic phases, respectively. The inter- and intra-observer variability of the semi-automatic segmentations were lower than observed in the manual segmentations. Both manual and semi-automatic segmentations performed better at the end-diastolic phase than at the end-systolic phase. The investigated semi-automatic segmentation method managed to produce a valid and reproducible alternative to manual right ventricle segmentation. 相似文献
6.
Dikkers R Greuter MJ Kristanto W van Ooijen PM Sijens PE Willems TP Oudkerk M 《European journal of radiology》2009,71(1):61-68
The purpose of this study was to evaluate the agreement between axial, multiplanar reformatted (MPR) and semi-automated software measurements of pulmonary vein ostial diameters and distance to the first bifurcation. CT examinations of the thorax were retrospectively reviewed in 150 consecutive patients. The pulmonary vein ostial diameter and distance to the first bifurcation of the four main pulmonary veins were independently measured. The three measurement methods were compared using a Bland-Altman test. There was no significant variation between pulmonary vein ostial diameter measurements for the superior pulmonary veins across the three measurement methods. There was significant variation between the semi-automated program and both the axial (p = 0.001) and MPR (p < 0.001) measured diameters for the right inferior pulmonary vein ostial diameter and between the MPR and semi-automated program measurements (p = 0.02) for the left inferior pulmonary vein ostial diameter. There was no significant variation between the pulmonary vein distance to first bifurcation measurements for any pulmonary vein across the three measurement methods. However, from a clinical perspective, differences were negligible; therefore, the clinician may confidently use any of the three measurement methods presented. 相似文献
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8.
Chemotherapy Negates the Effect of SDF1 mRNA to Distant Metastasis and Poor Overall Survival in Breast Cancer Patients 下载免费PDF全文
Kristanto Yuli YarsoMonica BellyndaAkhmad AzmiardiBrian WasitaDidik Setyo HeriyantoIndwiani AstutiMohammad HakimiTeguh Aryandono 《Asian Pacific journal of cancer prevention》2021,22(3):757-766
Objective: Investigate the effect of SDF1a, nuclear, and cytoplasmic CXCR4 breast cancer tissue on metastasis and overall survival in patients with complete-chemotherapy and no-chemotherapy. Methods: Cohort ambidirectional design was employed with survival analysis that followed the patient’s diagnosis until obtaining the outcome, distant metastasis, or death. We analyzed samples in three groups (all-patient, no-chemotherapy, and complete-chemotherapy groups). Breast cancer cell nuclear and cytoplasm expressions of CXCR4 protein were examined using immunohistochemistry. Amplification of mRNA SDF1a of breast cancer tissue was examined using rtPCR on 131 samples from the same initial paraffin block. Results: In the distant metastasis and Overall Survival (OS) analysis, there was no correlation between cytoplasmic and nuclear CXCR4 in all-patient, no-chemotherapy, and complete-chemotherapy groups. SDF1a was significantly correlated to shorter distant metastasis and poor OS in the all-patient (p=0.004 and p=0.04, respectively) and no-chemotherapy group (p=0.008 and p=0.026, respectively). However, in the complete-chemotherapy group, SDF1a was not correlated to either metastasis (p=0.527) or OS (p=0.993), advanced stage demonstrated a strong association on shorter distant metastatic in no-chemotherapy (p=0.021) and complete-chemotherapy group (p=0.004) and also poor OS in both groups (p=0.006 and p=0.002, respectively). The hormone receptor showed a protective effect on the no-chemotherapy group’s OS (p= 0.019). Meanwhile, not undergoing chemotherapy was associated with poor OS in the all-patient group (p= 0.011). Conclusion: SDF1a mRNA amplification has a significant correlation with the occurrence of metastasis and OS in all-patient and no-chemotherapy group. Undergoing chemotherapy negates the effect of SDF1a for distant metastasis and OS. 相似文献
9.
Video-Assisted Breast Surgery (VABS) and Vacuum-Assisted Breast Biopsy (VABB) for Fibroadenoma Mammae on Patients’ Satisfaction: A Preliminary Study 下载免费PDF全文
Kristanto Yuli YarsoMuhammad David Perdana PutraMonica BellyndaAkhmad Azmiardi 《Asian Pacific journal of cancer prevention》2021,22(11):3615-3621
Objective: This study aimed to compare the patients’ satisfaction level after fibroadenoma surgery with Video-Assisted Breast Surgery (VABS) and Vacuum-Assisted Breast Biopsy (VABB) techniques. Methods: Patients who underwent VABS or VABB for a diagnosis of fibroadenoma mammae at the Oncology Clinic in Solo, Indonesia were included in this study. Clinical and demographic data were obtained from medical records. Direct or telephone interviews were performed and the patients were asked to complete Universitas Sebelas Maret Breast Satisfaction Questionnaire 8 (UNS-BsQ8) questionnaire. Results: A total sample of 16 patients with VABS and 26 patients with VABB were recruited. All the patients were confirmed to have fibroadenoma based on the pathological result. The mean total scores for VABS and VABB were 34.50 ± 2.094 and 31.57 ± 3.081, respectively (P= 0.137). Out of 8 questions, only 3 items had statistically significant differences. VABS had higher mean score than VABB in terms of surgery cost (P = 0.002), pain in surgery site (P = 0.006), and pain in shoulder (P = 0.013). Conclusion: There was no significant difference in terms of overall patients’ satisfaction level between both groups. However, VABS had a higher mean score than VABB in terms of cost and pain. 相似文献
10.
Wisnumurti Kristanto Peter M. A. van Ooijen Marcel J. W. Greuter Jaap M. Groen Rozemarijn Vliegenthart Matthijs Oudkerk 《The international journal of cardiovascular imaging》2013,29(5):1137-1148
Computed tomography (CT) may characterize lipid-rich and presumably rupture-prone non-calcified coronary atherosclerotic plaque based on its Hounsfield-Unit (HU), but still inconclusively. This study aimed to evaluate factors influencing the HU-value of non-calcified plaque using software simulation. Several realistic virtual plaqueburdened coronary phantoms were constructed at 5 μm resolution. CT scanning was simulated with settings resembling a 64-row multi-detector CT (64-MDCT) and reconstructed at 64-MDCT (0.4 mm) and MicroCT (48 μm) resolutions. Influences of lumen contrast-enhancement, stenosis-grades, and plaque compositions on plaque visualization were analyzed. Lumen contrast-enhancement and mean plaque HU-value were positively correlated (R2 > 0.92), with approximately the same slopes for all plaque compositions. Percentage lipid-content and mean plaque HU-value were negatively correlated (R2 > 0.98). Stenosis-grade and noise had minimal influence on the correlations. Influence of lumen contrast-enhancement on plaque HU-value was following a specific exponentially declining pattern (y = Ae?λx + c) from the lumen border until 2-pixel radius. Outside 2-pixel radius, plaque HU-values deviated maximally 5 HU from non-contrast-enhanced reference. Thus, to avoid lumen contrast-enhancement influence, plaques should be measured outside 2-pixel radius from the lumen border. Based on the patterns found, a lumen influence correction algorithm may be developed. HU-based plaque percentage lipid-content determination might serve as an alternative plaque characterization method. However, its applicability is still hindered by many inherent limitations. 相似文献