全文获取类型
收费全文 | 36405篇 |
免费 | 3709篇 |
国内免费 | 85篇 |
专业分类
耳鼻咽喉 | 476篇 |
儿科学 | 983篇 |
妇产科学 | 743篇 |
基础医学 | 5212篇 |
口腔科学 | 1360篇 |
临床医学 | 4159篇 |
内科学 | 7264篇 |
皮肤病学 | 402篇 |
神经病学 | 2928篇 |
特种医学 | 1336篇 |
外国民族医学 | 2篇 |
外科学 | 4801篇 |
综合类 | 930篇 |
一般理论 | 30篇 |
预防医学 | 3835篇 |
眼科学 | 1004篇 |
药学 | 2801篇 |
1篇 | |
中国医学 | 27篇 |
肿瘤学 | 1905篇 |
出版年
2021年 | 522篇 |
2020年 | 329篇 |
2019年 | 552篇 |
2018年 | 599篇 |
2017年 | 442篇 |
2016年 | 469篇 |
2015年 | 575篇 |
2014年 | 807篇 |
2013年 | 1204篇 |
2012年 | 1662篇 |
2011年 | 1754篇 |
2010年 | 933篇 |
2009年 | 917篇 |
2008年 | 1541篇 |
2007年 | 1658篇 |
2006年 | 1508篇 |
2005年 | 1582篇 |
2004年 | 1433篇 |
2003年 | 1375篇 |
2002年 | 1351篇 |
2001年 | 1092篇 |
2000年 | 1152篇 |
1999年 | 1065篇 |
1998年 | 391篇 |
1997年 | 316篇 |
1996年 | 363篇 |
1995年 | 343篇 |
1994年 | 333篇 |
1993年 | 336篇 |
1992年 | 856篇 |
1991年 | 838篇 |
1990年 | 869篇 |
1989年 | 787篇 |
1988年 | 735篇 |
1987年 | 739篇 |
1986年 | 694篇 |
1985年 | 707篇 |
1984年 | 527篇 |
1983年 | 487篇 |
1982年 | 304篇 |
1981年 | 320篇 |
1980年 | 287篇 |
1979年 | 470篇 |
1978年 | 378篇 |
1977年 | 305篇 |
1976年 | 284篇 |
1974年 | 374篇 |
1973年 | 361篇 |
1972年 | 297篇 |
1971年 | 311篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
James A. Akingbasote Alison J. Foster Ian Wilson Sunil Sarda Huw B. Jones J. Gerry Kenna 《Archives of toxicology》2016,90(4):853-862
Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN?) mice exhibit normal hepatic and extrahepatic biotransformation enzyme activities when compared to wild-type (WT) mice, but express no functional hepatic cytochrome P450 activities. When incubated in vitro with [14C]-diclofenac, liver microsomes from WT mice exhibited extensive biotransformation to oxidative and glucuronide metabolites and covalent binding to proteins was also observed. In contrast, whereas glucuronide conjugates and a quinone-imine metabolite were formed when [14C]-diclofenac was incubated with HRN? mouse liver, only small quantities of P450-derived oxidative metabolites were produced in these samples and covalent binding to proteins was not observed. Livers from vehicle-treated HRN? mice exhibited enhanced lipid accumulation, bile duct proliferation, hepatocellular degeneration and necrosis and inflammatory cell infiltration, which were not present in livers from WT mice. Elevated liver-derived alanine aminotransferase, glutamate dehydrogenase and alkaline phosphatase activities were also observed in plasma from HRN? mice. When treated orally with diclofenac for 7 days, at 30 mg/kg/day, the severities of the abnormal liver histopathology and plasma liver enzyme findings in HRN? mice were reduced markedly. Oral diclofenac administration did not alter the liver histopathology or elevate plasma enzyme activities of WT mice. These findings indicate that HRN? mice are valuable for exploration of the role played by hepatic P450s in drug biotransformation, but poorly suited to investigations of drug-induced liver toxicity. Nevertheless, studies in HRN? mice could provide novel insights into the role played by inflammation in liver injury and may aid the evaluation of new strategies for its treatment. 相似文献
2.
3.
Rubens Souza de OLIVEIRA Lanna Jamile Corrêa da COSTA Fernanda Atanaena Gon?alves de ANDRADE Wilson UIEDA Luzia Fátima Alves MARTORELLI Ana Paula de Arruda Geraldes KATAOKA Elizabeth Salbé Travassos da ROSA Pedro Fernando da Costa VASCONCELOS Armando de Souza PEREIRA Ant?nio Ismael Barros do CARMO Marcus Emanuel Barroncas FERNANDES 《Revista do Instituto de Medicina Tropical de S?o Paulo》2015,57(6):497-503
The outbreaks of rabies in humans transmitted by Desmodus rotundus in 2004 and 2005,
in the northeast of the Brazilian State of Para, eastern Amazon basin, made this a
priority area for studies on this zoonosis. Given this, the present study provides
data on this phenomenon in an urban context, in order to assess the possible
circulation of the classic rabies virus (RABV) among bat species in Capanema, a town
in the Amazon basin. Bats were collected, in 2011, with mist nets during the wet and
dry seasons. Samples of brain tissue and blood were collected for virological and
serological survey, respectively. None of the 153 brain tissue samples analyzed
tested positive for RABV infection, but 50.34% (95% CI: 45.67-55.01%) of the serum
samples analyzed were seropositive. Artibeus planirostris was the most common
species, with a high percentage of seropositive individuals (52.46%, 95% CI: 52.31
52.60%). Statistically, equal proportions of seropositive results were obtained in
the rainy and dry seasons (c2 = 0.057, d.f. = 1, p = 0.88). Significantly
higher proportions of males (55.96%, 95% CI: 48.96-62.96%) and adults (52.37%, 95%
CI: 47.35-57.39%) were seropositive. While none of the brain tissue samples tested
positive for infection, the high proportion of seropositive specimens indicates that
RABV may be widespread in this urban area. 相似文献
4.
5.
6.
A. G. D. Maran J. A. Wilson M. N. Gaze 《European archives of oto-rhino-laryngology》1993,250(3):127-132
Summary Squamous cell carcinoma of the head and neck is a disease predominantly of males and is due to a variety of known environmental irritants, notably cigarette smoke. Dietary, viral and immunological factors may also be relevant. Head and neck squamous cancers express epidermal growth factor receptors and some show weak levels of oestrogen receptor activity, but a reliable serum marker of tumour burden remains to be identified. The prognosis is found to be less favourable in females, in those with advanced T stage, in association with multiple node involvement, especially where extracapsular spread is present and where the T4/T8 ratio is elevated. Administration of heterologous blood during therapy may also have an adverse effect on prognosis. Interested clinicians must remember that most cases are preventable.
Correspondence to: A.G.D. Maran 相似文献
7.
8.
We report a case of vasoactive-agent-induced priapism successfully treated in the emergency department with 10 mg of metaraminol injected into the corpora cavernosa. 相似文献
9.
10.