全文获取类型
收费全文 | 10246篇 |
免费 | 671篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 84篇 |
儿科学 | 207篇 |
妇产科学 | 268篇 |
基础医学 | 1435篇 |
口腔科学 | 108篇 |
临床医学 | 821篇 |
内科学 | 2406篇 |
皮肤病学 | 178篇 |
神经病学 | 896篇 |
特种医学 | 452篇 |
外科学 | 1488篇 |
综合类 | 42篇 |
一般理论 | 8篇 |
预防医学 | 838篇 |
眼科学 | 159篇 |
药学 | 861篇 |
中国医学 | 11篇 |
肿瘤学 | 676篇 |
出版年
2023年 | 51篇 |
2022年 | 55篇 |
2021年 | 164篇 |
2020年 | 128篇 |
2019年 | 190篇 |
2018年 | 200篇 |
2017年 | 192篇 |
2016年 | 216篇 |
2015年 | 222篇 |
2014年 | 346篇 |
2013年 | 476篇 |
2012年 | 699篇 |
2011年 | 771篇 |
2010年 | 427篇 |
2009年 | 405篇 |
2008年 | 621篇 |
2007年 | 675篇 |
2006年 | 595篇 |
2005年 | 601篇 |
2004年 | 553篇 |
2003年 | 475篇 |
2002年 | 454篇 |
2001年 | 209篇 |
2000年 | 183篇 |
1999年 | 214篇 |
1998年 | 114篇 |
1997年 | 112篇 |
1996年 | 119篇 |
1995年 | 91篇 |
1994年 | 102篇 |
1993年 | 80篇 |
1992年 | 127篇 |
1991年 | 102篇 |
1990年 | 101篇 |
1989年 | 105篇 |
1988年 | 84篇 |
1987年 | 79篇 |
1986年 | 73篇 |
1985年 | 68篇 |
1984年 | 60篇 |
1983年 | 38篇 |
1982年 | 38篇 |
1981年 | 36篇 |
1980年 | 36篇 |
1979年 | 35篇 |
1978年 | 15篇 |
1977年 | 16篇 |
1975年 | 16篇 |
1973年 | 16篇 |
1972年 | 16篇 |
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
1.
2.
Michiel R. de Boer Jos Twisk Annette C. Moll Hennie J. M. Völker-Dieben Henrica C. W. de Vet Ger H. M. B. van Rens 《Ophthalmic & physiological optics》2006,26(6):535-544
Consecutive patients (n = 215) who were referred to optometric (55%) or multidisciplinary (45%) low-vision services and above 50 years of age were recruited from four hospitals in the Netherlands. They completed two vision-related quality of life questionnaires, the Vision Quality of Life Core Measure (VCM1) and the Low Vision Quality of Life Questionnaire (LVQOL), before their first visit with low-vision services and 1 year later. At follow-up, patients referred to multidisciplinary low-vision services had lower scores on the mobility subscale of the LVQOL than patients referred to optometric low-vision services [5.3 points; 95% confidence interval (CI): 0.2-10.5]. Paired sample t-tests for the two groups of patients taken together show improvement for the VCM1 (3.1 points; 95% CI: 0.6-5.6) and deterioration for the basic aspects of vision (3.5 points; 95% CI: 1.1-5.9) and the mobility (6.6 points; 95% CI: 3.7-9.5) subscales of the LVQOL. In conclusion, people referred to optometric services showed less deterioration in mobility than those referred to multidisciplinary services. No differences were observed for any of the other subscales of the LVQOL and the VCM1. Future research in this field should include randomized controlled designs comparing low-vision services with no treatment or placebo. 相似文献
3.
Jan Willem R. Pott Kwok H. Wong 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,244(10):1357-1359
Background Leber’s hereditary optic neuropathy (LHON) is a maternally inherited optic neuropathy caused by mutations in mitochondrial DNA (mtDNA). It is also believed that several epigenetic factors have an influence on the development of LHON.Methods A case series was observed.Results Three patients who developed bilateral optic neuropathy are presented. All patients had a primary LHON mutation in their mtDNA, but also a subnormal vitamin B12 serum level at the time of presentation.Conclusions The clinical picture of optic neuropathy associated with vitamin B12 deficiency shows similarity to that of LHON. Both involve the nerve fibres of the papillomacular bundle. The present case reports suggest that optic neuropathy in patients carrying a primary LHON mtDNA mutation may be precipitated by vitamin B12 deficiency. Therefore, known carriers should take care to have an adequate dietary intake of vitamin B12 and malabsorption syndromes like those occurring in familial pernicious anaemia or after gastric surgery should be excluded. 相似文献
4.
Therapeutic Consequences of Variation in Intraarterial Pressure Measurements After Iliac Angioplasty
Eric Tetteroo Cees Haaring Andries D. van Engelen Yolanda van der Graaf Willem P.T.M. Mali 《Cardiovascular and interventional radiology》1997,20(6):426-430
Purpose: To assess the accuracy of intraarterial measurement of transstenotic pressure gradients for the detection of hemodynamically
suboptimal iliac angioplasty.
Methods: In 14 patients, referred for diagnostic angiography, mean pressure gradients in the aorta and iliac artery were obtained
twice, using a double-sensor pressure catheter. Additional iliac measurements were performed during pharmacologically induced
flow augmentation. Repeatability was assessed by calculation of the mean difference plus standard deviation (MD ± SD) and
repeatability coefficient (2 × SD). These results were extrapolated to 137 iliac angioplasty procedures with secondary stenting
where there was a residual pressure gradient > 10 mmHg.
Results: MD ± SD for repeated measurements at rest and during flow augmentation were 0 ± 2 mmHg and 1 ± 3 mmHg, respectively. Repeatability
coefficients were 3 and 6 mmHg. Mean pressure gradients after hemodynamically insufficient angioplasty were 8 ± 7 mmHg at
rest and 17 ± 5 mmHg following vasodilatation. Inaccurate pressure recordings may have led to inappropriate stent placement
in less than 2.5%, and inappropriate denial of stent placement in less than 5% of the lesions.
Conclusion: Variability of intraarterial pressure measurements has little consequence in the detection of hemodynamically significant
stenosis after angioplasty.
Received: 0/00/00/Accepted: 0/00/00 相似文献
5.
C Niek van Dijk Ben Willem J. Mol Liesbeth S. L. Lim Rene K. Marti Patrick M. M. Bossuyt 《Acta orthopaedica》1996,67(6):566-570
We prospectively enrolled 160 consecutive patients with inversion trauma of the ankle in a diagnostic protocol that included physical examination within 2 days and at 5 days after trauma, arthrography, stress radiography, and ultrasonography. 135 patients had pathological lateral ligament laxity on the later physical examination or lateral ligament rupture diagnosed on arthrography and they were operated on. 122 of these patients had ligament ruptures.
At clinical follow-up after a minimum of half a year, all of the patients who were not operated on had stable joints without signs of previous ligament ruptures.
Delayed physical examination at 5 days after the injury led to the highest overall sensitivity (96%) and specificity (84%) for the detection of a ligament rupture. Additional diagnostic procedures, at a considerable cost, yielded little additional information. 相似文献
At clinical follow-up after a minimum of half a year, all of the patients who were not operated on had stable joints without signs of previous ligament ruptures.
Delayed physical examination at 5 days after the injury led to the highest overall sensitivity (96%) and specificity (84%) for the detection of a ligament rupture. Additional diagnostic procedures, at a considerable cost, yielded little additional information. 相似文献
6.
7.
8.
9.
Hans D de Boer Jan van Egmond Jacques J Driessen Leo HD Booij 《Neuropsychiatric Disease and Treatment》2007,3(5):539-544
Steroidal neuromuscular blocking agents (NMBAs), such as rocuronium, are widely used in clinical anesthesia and emergency medicine to facilitate endotracheal intubation and artificial ventilation and to allow surgical access to body cavities. Reversal of neuromuscular blockade is important for the acceleration of patient recovery and prevention of postoperative residual neuromuscular blockade and reduces the incidence of severe morbidity and mortality associated with anesthesia management. Sugammadex is the first selective relaxant binding agent (SRBA) and has been designed to reverse the steroidal neuromuscular blocking drug rocuronium. Encapsulation of the rocuronium molecule by sugammadex results in a rapid decrease in free rocuronium in the plasma and subsequently at the nicotinic receptor at the motor endplate. After encapsulation, rocuronium is not available to bind to the nicotinic receptor in the neuromuscular junction. This promotes the liberation of acetylcholine receptors, and muscle activity reappears. This new concept of reversal of neuromuscular block induced by rocuronium (or vecuronium) led to impressive results in animal and phase 1 and 2 studies. Sugammadex is currently in phase 3 clinical studies and may be commercially available by 2008. 相似文献
10.