全文获取类型
收费全文 | 3168篇 |
免费 | 160篇 |
国内免费 | 25篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 58篇 |
妇产科学 | 57篇 |
基础医学 | 519篇 |
口腔科学 | 26篇 |
临床医学 | 298篇 |
内科学 | 609篇 |
皮肤病学 | 218篇 |
神经病学 | 274篇 |
特种医学 | 114篇 |
外科学 | 481篇 |
综合类 | 19篇 |
一般理论 | 2篇 |
预防医学 | 197篇 |
眼科学 | 19篇 |
药学 | 234篇 |
中国医学 | 9篇 |
肿瘤学 | 187篇 |
出版年
2023年 | 21篇 |
2022年 | 69篇 |
2021年 | 100篇 |
2020年 | 60篇 |
2019年 | 82篇 |
2018年 | 84篇 |
2017年 | 46篇 |
2016年 | 70篇 |
2015年 | 73篇 |
2014年 | 103篇 |
2013年 | 120篇 |
2012年 | 218篇 |
2011年 | 228篇 |
2010年 | 95篇 |
2009年 | 96篇 |
2008年 | 176篇 |
2007年 | 184篇 |
2006年 | 152篇 |
2005年 | 141篇 |
2004年 | 119篇 |
2003年 | 113篇 |
2002年 | 95篇 |
2001年 | 34篇 |
2000年 | 30篇 |
1999年 | 25篇 |
1998年 | 29篇 |
1997年 | 14篇 |
1995年 | 23篇 |
1994年 | 29篇 |
1992年 | 21篇 |
1989年 | 15篇 |
1988年 | 22篇 |
1987年 | 23篇 |
1986年 | 15篇 |
1985年 | 27篇 |
1984年 | 16篇 |
1983年 | 18篇 |
1981年 | 14篇 |
1979年 | 12篇 |
1978年 | 12篇 |
1974年 | 23篇 |
1972年 | 15篇 |
1971年 | 16篇 |
1929年 | 12篇 |
1921年 | 17篇 |
1914年 | 15篇 |
1913年 | 27篇 |
1912年 | 22篇 |
1911年 | 17篇 |
1903年 | 16篇 |
排序方式: 共有3353条查询结果,搜索用时 15 毫秒
1.
Sundaram Kavin Piuzzi Nicolas S. Patterson Brendan M. Stearns Kim L. Krebs Viktor E. Mont Michael A. 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2020,30(3):447-453
European Journal of Orthopaedic Surgery & Traumatology - The goals of this study were to compare patient satisfaction and wound-related complications in patients receiving 2-octyl cyanoacrylate... 相似文献
2.
3.
Frank G. Shellock Jerrold H. Mink Andrew L. Deutsch James Fox Todd Molnar Ronald Kvitne Richard Ferkel 《Journal of magnetic resonance imaging : JMRI》1994,4(4):590-594
The effect of a newly developed patellar realignment brace was evaluated in 21 patellofemoral joints (19 patients) with patellar subluxation (13 joints with lateral subluxation and eight with medial subluxation) by using active-movement, loaded kinematic magnetic resonance (MR) imaging. Sixteen patellofemoral joints (76%) demonstrated a qualitative correction of or improvement in patellar subluxation (ie, centralization of the patella or a decrease in the displacement of the patella) after application of the brace. Four of the five “failures” occurred in patellofemoral joints that had patella alta and/or dysplastic bone anatomy. These results indicate that the patellar realignment brace was able to counteract patellar subluxation in the majority of patellofemoral joints studied, as shown by active-movement, loaded kinematic MR imaging. This brace appears to be useful for conservative treatment of patients with patellofemoral joint pain secondary to patellar malalignment and maltracking. 相似文献
4.
Silvia Samarin Lovric Viktor Avbelj Roman Trobec Darko Zorman Peter Rakovec Sergej Hojker Borut Gersak Metka Milcinski 《European journal of cardio-thoracic surgery》2004,26(4):736-741
OBJECTIVE: Complete allograft denervation occurs during heart transplantation. Partial ventricular sympathetic reinnervation may develop one year or later after transplantation and can be measured with iodine-123-meta-iodobenziylguanidine (MIBG) uptake. Aim of this study was to assess sinus node sympathetic reinnervation measured with heart rate variability and ventricular sympathetic reinnervation evaluated with MIBG. METHODS: Twelve patients and 14 healthy controls were included. In patients, MIBG scintigraphy with early and late imaging was performed. Heart to mediastinum ratio (HMR) was calculated and patients were divided in groups with (HMR>1.3) and without left ventricular reinnervation (HMR<1.3). Bipolar ECG with high sampling rate and resolution was recorded over 8.5 min in supine position and in upright position after 10 min interval. R-R intervals in time domain and heart rate variability in frequency domain through spectral power analysis of R-R intervals were analysed to evaluate sinus node reinnervation. Spectral power in low frequency range (0.04-0.15 Hz) above 4.5 ms(2) was considered as sinus node sympathetic reinnervation. RESULTS: Six (50%) patients had evidence of left ventricular sympathetic reinnervation on scintigraphy. Sinus node sympathetic reinnervation based on heart rate variability was detected in 6 (50%) patients in supine, and in 4 (33%) patients in upright body position. Four patients groups were discerned: (1) with ventricular and sinus node sympathetic reinnervation, (2) with sinus node sympathetic reinnervation, (3) with ventricular sympathetic reinnervation and (4) without atrial or ventricular sympathetic reinnervation. Ventricular reinnervation process was time dependent and sinus node reinnervation was not. CONCLUSIONS: Simultaneous ventricular sympathetic reinnervation assessed by MIBG and sinus node sympathetic reinnervation assessed by heart rate variability in supine as in upright position were detected only in two patients (17%). The results of our study show that eventual sinus node sympathetic reinnervation and left ventricular sympathetic reinnervation do not occur simultaneously. 相似文献
5.
6.
Eduardo Martínez-Soria Viktor Steimle Charlotte Burkhardt Pascale Beffy Jean-Marie Tiercy Jrg T. Epplen Bernard Mach Claude Irl 《Human immunology》1994,40(4)
The T-cell recognition of HLA-DR-peptide complexes is generally restricted by the polymorphism of the DRB molecules but pluriallelic restriction has been described. The molecular basis of restriction and promiscuity of such peptide-specific responses is poorly understood. We isolated a panel of T-cell lines specific for the tetanus toxin peptide p2 (TT830-843) exhibiting pluriallelic restriction by DR11 and DR8 alleles. Fine restriction specificity of the T-cell lines was examined in functional assays against DR oligotyped APCs expressing different variants of DR11 and DR8 alleles. Our results show that (a) polymorphisms between serologically related alleles are relevant in terms of restriction of the peptide-specific T-cell response; in some instances, a single amino acid substitution can determine the restriction of a T-cell line; (b) different patterns of restriction are not the result of specific differences in DR-p2 binding as p2 peptide binds to all DR11 and DR8 alleles tested (DRB1* 1101, -1102, -1103, -1104, 110X, -0801, -0802, -0803, and -0806); and (c) pluriallelic restriction of the peptide-specific T-cell responses correlates with the presence of a DRB1 α-helix motif (67-71-86) shared by some DR11 and DR8 alleles. Possible implications of pluriallelic restriction of peptide-specific T-cell response in autoimmune disorders associated with DR11 and DR8 are discussed. 相似文献
7.
8.
Thomas F Molnar 《European journal of cardio-thoracic surgery》2007,31(2):311-312
In order to provide a precise lymph node mapping during lung cancer surgery a sterilizable plastic tray moulded in the shape of the mediastinum and lungs is presented by the author. The device makes lymph node mapping simpler, safer, quicker and methodically more structured. A positive impact is expected as a result of usage of the device from making pathologist's work easier and facilitating the flux of information on the surgeon-pathologist-oncologist-pneumonologist chain to be more disinformation-free. 相似文献
9.
Current surgical treatment of thoracic empyema in adults. 总被引:1,自引:0,他引:1
Thomas F Molnar 《European journal of cardio-thoracic surgery》2007,32(3):422-430
A review of the recent literature on treatment modalities of adult thoracic empyema was conducted in order to expose the controversies and verify where consensus exists. Critical reading filtered through clinical experience was the method followed. The roles of surgical drainage, lavage techniques, debridement via VATS, decortication, thoracoplasty and open window thoracostomy were considered using the Oxford Center of Evidence Based Medicine criteria. The roles of the different therapeutical modalities were interpreted in the light of the triphasic nature of empyema thoracis. The randomised controlled trials came up with conflicting results. With two exceptions all of the papers reviewed provide level (2b) or below evidences. The lack of a single ideal treatment modality or policy reflects the complexity of the diagnosis and staging of this heterogeneous disease. Basic elements of intervention--drainage, different evacuation techniques, decortication, thoracoplasty and open window thoracostomy--are well-established technical modalities; however, neither a universally acceptable primary modality nor the gold standard of their sequence is available. Drainage remains to be the initial treatment modality in Phase I disease. Debridement via VATS is a safe, reliable and efficient method in the fibrinopurulent phase. Organised pleural callus requires formal decortication. Open window thoracostomy is a simple and safe procedure for high-risk patients and results in quick detoxication. Thoracoplasty kept its final role in pleural space management. Acute postoperative bronchial stump insufficiency requires immediate surgery. Evacuation of toxic material is mandatory. No single-stage procedure offers a solution. An optimised agressivity treatment modality should be tailored to the condition of the patient and to the potential of the persisting cavity. Decision-making involves a triad consisting of the aetiology of empyema (i.e. primary vs secondary), general condition of the patient and stage of disease, while considering the triphasic nature of development of thoracic empyema. The current attitudes show that the present concepts are based mainly on expert opinion. Flexibility and patience on behalf of the surgeon and nursing staff, the patient and the hospital management, as well as a good understanding of the complexity of this condition are the cornerstones of the treatment. No exclusive sequence of procedures leading to a uniformly predictable successful outcome is available. Individualised approaches can be recommended based on institutional practice and local protocols. Thoracic empyema in general seems to remain resilient to fit completely into the categories of evidence-based medical approach. 相似文献
10.
The influence of age, height, and body weight on cerebrospinal fluid amine metabolites and tryptophan in women 总被引:1,自引:0,他引:1
Cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5HIAA), homovanillic acid, and tryptophan were measured in 33 depressed, 36 alcoholic, and 32 neurological control female patients selected by strict operational criteria and investigated under controlled circumstances. Plasma total tryptophan was also measured in blood samples taken simultaneously with lumbar punctures. A multivariate regression analysis was done to discover the effect of age, height, and body weight on these four biochemical measures. Only CSF 5HIAA was significantly dependent on the nonspecific patient variables: height, but neither age nor weight, accounted for more than 10% of the variance of 5HIAA. The same analysis was carried out in all three separate patient groups: the relationship between height and CSF 5HIAA was present throughout, and only 2 of 12 correlations proved to be non-homogeneous. To demonstrate the significantly of these clinical parameters a multivariate analysis of covariance was done to eliminate their effect on the four biochemical variables. As a result significant differences emerged in CSF 5HIAA and total plasma tryptophan for some of the patient groups which were not demonstrable without this correction. 相似文献