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1.
Esaki Muthu Shankar Ramachandran Vignesh Kailapuri G Murugavel Pachamuthu Balakrishnan Ramalingam Sekar Charmaine AC Lloyd Suniti Solomon Nagalingeswaran Kumarasamy 《AIDS research and therapy》2007,4(1):1-7
Background
CD4+ T lymphocyte (CD4) cell count testing is the standard method for determining eligibility for antiretroviral therapy (ART), but is not widely available in sub-Saharan Africa. Total lymphocyte counts (TLCs) have not proven sufficiently accurate in identifying subjects with low CD4 counts. We developed clinical algorithms using TLCs, hemoglobin (Hb), and body mass index (BMI) to identify patients who require ART. 相似文献2.
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Vignesh T. Packiam Craig V. Labbate Stephen A. Boorjian Robert Tarrell John C. Cheville Svetlana Avulova Vidit Sharma Matvey Tsivian Brittany Adamic Mohammad Mahmoud Ryan P. Werntz Norm D. Smith R. Jeffrey Karnes Matthew K. Tollefson Gary D. Steinberg Igor Frank 《Urologic oncology》2021,39(7):436.e1-436.e8
IntroductionWhile numerous current clinical trials are testing novel salvage therapies (ST) for patients with recurrent nonmuscle invasive bladder cancer (NMIBC) after bacillus Calmette-Guérin (BCG), the natural history of this disease state has been poorly defined to date. Herein, we evaluated oncologic outcomes in patients previously treated with BCG and ST who subsequently underwent radical cystectomy (RC).MethodsWe identified 378 patients with high-grade NMIBC who received at least one complete induction course of BCG (n = 378) with (n = 62) or without (n = 316) additional ST and who then underwent RC between 2000 and 2018. Oncologic outcomes were compared using the Kaplan-Meier method and Cox proportional hazards models. Sensitivity analyses were conducted stratifying by presenting tumor stage, matched 1:3 for receipt vs. no receipt of ST.ResultsPatients receiving ST were more likely to initially present with CIS (26% vs. 17%) and less likely with T1 disease (34% vs. 50%, P = 0.06) compared to patients not treated with ST. Receipt of ST was not associated with increased risk of adverse pathology (≥pT2 or pN+) at RC (31% vs. 41%, P = 0.14). Likewise, 5-year cancer-specific survival did not significantly differ between groups on univariable Kaplan-Meier analysis (73% for ST and 74% for no ST, P = 0.7). Moreover, on multivariable analysis, receipt of ST was not significantly associated the risk of death from bladder cancer (HR 1.12; 95% CI 0.60–2.09, P = 0.7). Results were unchanged on sensitivity analysis.ConclusionsThese data suggest that, in carefully selected patients, ST following BCG for high grade NMIBC does not compromise oncologic outcomes for patients who ultimately undergo RC. 相似文献
4.
Vignesh Pandiarajan Barman Prabal Basu Suprit Mondal Sanjib Ishran Bhoomika Kumrah Rajni Dod Aditya Garg Ravinder Rawat Amit Singh Surjit 《Immunologic research》2023,71(1):112-120
Immunologic Research - Juvenile dermatomyositis (JDM) is the commonest inflammatory myositis in children. The clinical phenotype is often characterized by the presence of myositis-specific... 相似文献
5.
Saravana Kumar Jaganathan Muthu Vignesh Vellayappan Gayathri Narasimhan Eko Supriyanto 《World journal of gastroenterology : WJG》2014,20(16):4618-4625
Colorectal cancer is the second leading cause of cancer-related deaths in the United States.Recent studies prove that though chemotherapeutic agents are being used for the treatment of colon cancer,they become non-effective when the cancer progresses to an invasive stage.Since consumption of certain dietary agents has been linked with various cancers,fruit juices have been investigated for their consistently protective effect against colon cancer.The unique biochemical composition of fruit juices is responsible for their anticancer properties.In this review,the chemo-preventive effect of fruit juices such as pomegranate and citrus juices against colon cancer are discussed.For this purpose,the bioavailability,in vitro and in vivo effects of these fruit juices on colorectal cancer are highlighted.Moreover,there is a scarcity of studies involving human trials to estimate the preventive nature of these juices against colon cancer.This review will support the need for more preclinical tests with these crude juices and their constituents in different colorectal cancer cell lines and also some epidemiological studies in order to have a better understanding and promote pomegranate and citrus juices as crusaders against colon cancer. 相似文献
6.
Kristen E. Rhodin Vignesh Raman Oliver K. Jawitz Soraya L. Voigt Norma E. Farrow David H. Harpole Betty C. Tong Thomas A. D’Amico 《The Annals of thoracic surgery》2021,111(2):440-447
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Anil Thomas Oommen Vignesh Prasad Krishnamoorthy Pradeep Mathew Poonnoose Ravi Jacob Korula 《Indian Journal of Orthopaedics》2015,49(2):181-186
Background:
The use of allografts and autografts in the management of acetabular defects have been reported with varying results. Trabecular metal is an expensive option in the management of these defects. This study aims to assess the fate and efficacy of bone grafting for acetabular bone defects in total hip arthroplasty.Materials and Methods:
A total of 30 hips in 28 patients with acetabular deficiencies were treated with bone grafting and total hip replacement (THR). Seventeen hips had American Academy of Orthopedic Surgeons (AAOS) type 2 (Paprosky type 2c) deficiency and 13 had AAOS type 3 (Paprosky type 3a) defects of the acetabulum. Allografts were used in 15 patients and autografts were used in the remaining 13. Cemented total hip arthroplasty was done in 18 hips and uncemented THR in 12. Seven patients underwent the procedure for, acetabular erosion and symptoms following hemiarthroplasty (4 out of 7), or, acetabular revision for failure (3 out of 7) following total hip arthroplasty. Acetabular deficiencies in other patients were due to posttraumatic causes, advanced primary hip arthritis and second stage treatment of postinfective arthritis. A mesh was used in 6 hips and screws were used in 13 hips for graft fixation.Results:
Patients were followed up clinicoradiologically for a period of 10 months to 4 years (mean 23.4 months). One patient required staged revision due to infection. Two patients had early asymptomatic cup migration. One patient had graft lysis and change in cup inclination with persistent pain. He was not keen on further intervention at last followup. Other patients were pain free at the time of followup with radiographs showing maintenance of graft and implant position.Conclusion:
Bone grafting is a suitable option in the management of acetabular defects in total hip arthroplasty, especially in resource challenged countries. 相似文献9.
A MicroRNA-Based Test Improves Endoscopic Ultrasound–Guided Cytologic Diagnosis of Pancreatic Cancer
Randall E. Brand Alex T. Adai Barbara A. Centeno Linda S. Lee George Rateb Shivakumar Vignesh Charles Menard Anna Wiechowska–Kozłowska Hubert Bołdys Marek Hartleb Michael K. Sanders Johanna B. Munding Andrea Tannapfel Stephan A. Hahn Ludomir Stefańczyk Gregory J. Tsongalis David C. Whitcomb Darwin L. Conwell Jean A. Morisset Timothy B. Gardner Stuart R. Gordon Arief A. Suriawinata Maura B. Lloyd Dennis Wylie Emmanuel Labourier Bernard F. Andruss Anna E. Szafranska–Schwarzbach 《Clinical gastroenterology and hepatology》2014,12(10):1717-1723
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