全文获取类型
收费全文 | 692篇 |
免费 | 55篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 22篇 |
妇产科学 | 10篇 |
基础医学 | 87篇 |
口腔科学 | 7篇 |
临床医学 | 80篇 |
内科学 | 205篇 |
皮肤病学 | 3篇 |
神经病学 | 18篇 |
特种医学 | 11篇 |
外科学 | 115篇 |
综合类 | 12篇 |
预防医学 | 29篇 |
眼科学 | 4篇 |
药学 | 119篇 |
中国医学 | 4篇 |
肿瘤学 | 19篇 |
出版年
2023年 | 5篇 |
2022年 | 6篇 |
2021年 | 22篇 |
2020年 | 8篇 |
2019年 | 13篇 |
2018年 | 19篇 |
2017年 | 15篇 |
2016年 | 15篇 |
2015年 | 23篇 |
2014年 | 29篇 |
2013年 | 27篇 |
2012年 | 37篇 |
2011年 | 36篇 |
2010年 | 25篇 |
2009年 | 18篇 |
2008年 | 27篇 |
2007年 | 17篇 |
2006年 | 24篇 |
2005年 | 28篇 |
2004年 | 27篇 |
2003年 | 37篇 |
2002年 | 35篇 |
2001年 | 25篇 |
2000年 | 14篇 |
1999年 | 17篇 |
1997年 | 3篇 |
1996年 | 7篇 |
1995年 | 3篇 |
1993年 | 5篇 |
1992年 | 17篇 |
1991年 | 27篇 |
1990年 | 18篇 |
1989年 | 9篇 |
1988年 | 8篇 |
1987年 | 5篇 |
1986年 | 12篇 |
1985年 | 13篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 6篇 |
1976年 | 5篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1972年 | 4篇 |
1971年 | 5篇 |
1967年 | 3篇 |
1935年 | 2篇 |
排序方式: 共有748条查询结果,搜索用时 0 毫秒
1.
2.
Assay of FK 506 in plasma. 总被引:1,自引:0,他引:1
3.
4.
Cyclosporine and its metabolites in mother and baby 总被引:3,自引:0,他引:3
R Venkataramanan B Koneru C C Wang G J Burckart S N Caritis T E Starzl 《Transplantation》1988,46(3):468-469
5.
6.
H Furukawa O Imventarza R Venkataramanan M Suzuki Y Zhu V S Warty J Fung S Todo T E Starzl 《Transplantation》1992,53(4):722-725
Mongrel or beagle dogs were submitted to bile duct ligation, or to extraenteric biliary diversion by means of choledochoureterostomy. The kinetics of intravenously administered FK506 was not changed from control status two weeks after bile duct ligation, but the bioavailability of orally administered FK506 was nearly quadrupled. Following oral administration, the absorption of FK506 was highly variable. The results indicate that in dogs FK506 is absorbed from the intestine just as efficiently in the absence of enteric bile and in presence of exogenous bile salt supplement when compared with its absorption in presence of normal bile drainage. These findings with FK506 are different from those with cyclosporine after biliary obstruction or diversion and will have important practical as well as experimental ramifications. 相似文献
7.
8.
Prakash N. Rao PhDa f Xin Cai MDa f Raman Venkataramanan PhDb Jeffrey L. Platt MDd Anthony Demetris MDa c Allen Thunberg MDe Connie Faltynek PhDe Thomas Starzl MD PhDa Prem Kumar MDf 《The Journal of allergy and clinical immunology》1995,95(6)
Reperfusion after ischemia results in endothelial cell injury and Kupffer cell activation. Inflammatory cytokines thus released can induce major histocompatibility complex antigens and increase the immunogenecity of the graft. An orthotopic rat liver allotransplant model was used to test the hypothesis that prevention of reperfusion injury by infusion of polyethylene glycol superoxide dismutase (PEG-SOD) would result in long-term allograft survival in the presence of subthreshold immunosuppressive dosages. ACI rats were used as donors, and Lewis strain rats as recipients. Orthotopic liver transplantation was initially performed to identify a subthreshold dose of the immunosuppressant FK-506, which would be unable to extend survival longer than control untreated rats with this strain combination. After testing three intramuscular FK-506 doses of 0.04, 0.08, and 0.16 mg/kg, it was observed that an FK-506 dose of 0.04 mg/kg/day for 14 days was unable to extend survival longer than in untreated recipients. This dose of FK-506 was used in combination with PEG-SOD at doses of 1000, 3000, 10,000, or 30,000 units. Recipient animals were treated intravenously with PEG-SOD as a loading dose to facilitate tissue penetration on day 1, and beginning on the day of transplantation, every 2 days for the duration of the study. Results of histologic studies and mean survival time were compared in untreated recipients and in rats treated with PEG-SOD plus 0.04 mg/kg/day FK-506. Mean survival time was increased significantly in these animals (p < 0.007) to 40.6 ± 25.6 days as compared with either untreated rats (10.0 ± 2.7 days) or rats treated with 0.04 mg/kg FK-506 alone (13.7 ± 4.2 days). Histologic examination demonstrated a significant reduction in the cellular infiltrate in rats treated with PEG-SOD plus FK-506, as compared with recipients treated with either agent alone or left untreated. Our results therefore suggest a potential approach to reducing immunosuppression in transplantation. (J ALLERGY CLIN IMMUNOL 1995;95:1276-81.) 相似文献
9.
S Kim U Boege S Krishnaswamy I Minor T J Smith M Luo D G Scraba M G Rossmann 《Virology》1990,175(1):176-190
The structure of Mengo virus had been determined from crystals grown in the presence of 100 mM phosphate buffer at pH 7.4. It is shown that Mengo virus is poorly infectious at the phosphate concentration similar to that in which it was crystallized. Maximal infectivity is achieved at 10 mM phosphate or less in physiological saline. The phosphate effect is ameliorated when the pH is lowered to 4.6. Although it has not been possible to study the crystal structure of the virus at low phosphate concentrations, it is shown that increasing the Cl- concentration at pH 6.2 or decreasing the pH to 4.6 causes substantial conformational changes confined to the "pit," a deep surface depression. These structural changes involve a movement of the "FMDV loop" (GH loop) in VP1, an ordering of the "VP3 loop" (GH loop in VP3) between 3176 and 3182, the displacement of a bound phosphate near the "FMDV loop" (GH loop in VP1), and movement of the carboxy terminus of VP2. The changes in conformation are correlated with the dissociation of the virion into pentamers at pH 6.2 and 150 mM Cl-. The localization of the conformational changes and the correlated role of the phosphate in controlling infectivity support the hypothesis that the "pit" is the receptor attachment site. 相似文献
10.
Rodent models of rheumatoid arthritis (RA) are useful tools to study the pathogenic process of RA. Among the most widely used models of RA are the streptococcal cell wall (SCW) arthritis model and the collagen-induced arthritis (CIA). Both innate and adaptive immune mechanisms are involved in these rodent models. While no models perfectly duplicate the condition of human RA, they are easily reproducible, well defined and have proven useful for development of new therapies for arthritis, as exemplified by cytokine blockade therapies. Besides SCW and CIA models, there are numerous others including transgenic models such as K/BxN, induced models such as adjuvant-induced and pristane models, and spontaneous models in certain mouse strains, that have been used to help understand some of the underlying mechanisms. This review provides an update and analysis of RA models in mice and rats. The array of models has provided rheumatologists and immunologists a means to understand the multifactorial disease in humans, to identify new drug targets, and to test new therapies. 相似文献