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1.
H. Gavriel T. Lazarovitch A. Pomortsev E. Eviatar 《European journal of clinical microbiology & infectious diseases》2009,28(1):27-31
Microbiologic studies are routinely performed in the assessment of peritonsillar abscess (PTA). Though the bacterial growth
rates of PTA are expected to be uniform due to high accessibility and reasonable sterility, they demonstrate a vast range
of results, which is partially explained by the differing culturing methods and incubation times. Our aim was to retrospectively
examine the changing features identified in the occurrence of PTA bacterial growth rates over a period of seven years. A retrospective
study was undertaken on all cases of PTA admitted from January 1996 to December 2002. Details regarding sex, age and country
of birth were obtained. Population data and the maximum residue level (MRL) of antibiotics in food were collected. Bacteriologic
studies were analysed for gram stain, aerobic and anaerobic culture results, and also antibiotic sensitivities, if obtained.
Four hundred and fifty-seven consecutive hospitalisations due to PTA were identified; 281 patients who had 310 hospitalisations
with known results of the microbiologic studies were included. The most common pathogens were Streptococcus pyogenes and Prevotella. A statistically significant escalation was seen in the anaerobic growth rate from 6.8% of cases in 1996 to 37% in 1999.
A similar change, though not significant, was noticed with the polymicrobial growth rate. None of the parameters investigated
showed any statistically significant influence on this tendency. These results may clarify the immense range of bacterial
study results reported, suggest a change in the biologic behaviour of the studied bacteria and direct further research. 相似文献
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Ruthy Tal-Jasper David E. Katz Nadav Amrami Dor Ravid Dori Avivi Ronit Zaidenstein Tsilia Lazarovitch Mor Dadon Keith S. Kaye Dror Marchaim 《Antimicrobial agents and chemotherapy》2016,60(5):3127-3131
Carbapenems are considered the treatment of choice for Acinetobacter baumannii infections. Many facilities implement preventive measures toward only carbapenem-resistant A. baumannii (CRAB). However, the independent role of the carbapenem resistance determinant on patient outcomes remains controversial. In a 6-year analysis of adults with A. baumannii bloodstream infection (BSI), the outcomes of 149 CRAB isolates were compared to those of 91 patients with carbapenem-susceptible A. baumannii. In bivariable analyses, CRAB BSIs were significantly associated with worse outcomes and with a delay in the initiation of appropriate antimicrobial therapy (DAAT). However, in multivariable analyses, carbapenem resistance status was no longer associated with poor outcomes, while DAAT remained an independent predictor. The epidemiological significance of A. baumannii should not be determined by its resistance to carbapenems. 相似文献
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Goldman M Rosenfeld-Yehoshua N Lerner-Geva L Lazarovitch T Schwartz D Grisaru-Soen G 《Pediatric nephrology (Berlin, Germany)》2008,23(5):765-768
This retrospective chart review sought to determine clinical, radiological, and gender-associated characteristics of community-acquired
Pseudomonas aeruginosa (PA) urinary tract infections (UTIs) among children admitted to two medical centers. The records of 73 children with community-acquired
PA UTIs were compared with records of 109 children with community-acquired UTIs caused by other pathogens. The mean age of
both groups was similar. The PA UTI group included more boys. Features significantly more common in the PA UTI group were
the number of patients who had undergone urinary tract surgery, patients with skeletal and/or neurological malformation, patients
with >1 previous episode of UTI, patients on prophylactic antibiotic treatment on admission, and patients with pathological
renal ultrasound and voiding cystourethrography (VCUG) findings. Multivariate logistic regression analysis revealed the following
to be associated with PA UTI: >1 episode of UTI in the past [odds ratio (OR) = 35.5; 95% confidence interval (CI) 11.6–108.7],
previous urinary tract surgery (OR = 34.1; 95% CI 7.00–166.2), and pathological VCUG results (OR = 2.62; 95% CI 0.96–7.15).
In conclusion, PA UTI is associated with >1 previous UTI, urinary tract abnormalities, and past urinary tract surgery. We
recommend that when UTI is suspected in children with these risk factors, a thorough radiologic investigation, including a
VCUG, should be considered.
Drs. Goldman and Rosenfeld-Yehoshua contributed equally to this work. 相似文献
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Antibiotic treatment of intra-amniotic infection with Ureaplasma urealyticum. A case report and literature review 总被引:2,自引:0,他引:2
Smorgick N Frenkel E Zaidenstein R Lazarovitch T Sherman DJ 《Fetal diagnosis and therapy》2007,22(2):90-93
BACKGROUND: Ureaplasma urealyticum is the most common pathogen cultured from the amniotic cavity of women with preterm labor and intact membranes. However, experience with antibiotic eradication of the pathogen in this setting is limited. CASE: We report a case of U. urealyticum isolation from the amniotic cavity of a woman with preterm labor at 27 weeks gestation. The patient was treated with erythromycin base for 1 week, followed by fluoroquinolones and clindamycin for 10 days. A healthy neonate was delivered after spontaneous labor began at 33 weeks. The cultures obtained from the placenta and membranes were sterile, but the histopathology of the placenta revealed acute chorioamnionitis with acute funisitis. CONCLUSION: We suggest that intra-amniotic colonization with Mycoplasma spp. remote from term may be managed expectantly, and that therapy with fluoroquinolones and/or clindamycin may be an appropriate choice. 相似文献
6.
Epidemiology of bacteremia episodes in a single center: increase in Gram-negative isolates, antibiotics resistance, and patient age 总被引:1,自引:0,他引:1
D. Marchaim R. Zaidenstein T. Lazarovitch Y. Karpuch T. Ziv M. Weinberger 《European journal of clinical microbiology & infectious diseases》2008,27(11):1045-1051
Increased resistance among isolates causing bacteremia constitutes a major challenge to medical practitioners and institutions.
Variability between institutes is substantial, and requires the individual analysis of local trends. An eight-year (1997–2004)
surveillance study of episodes of bacteremia was conducted in an 850-bed university hospital in central Israel. Trends of
incidence, resistance, age, and mortality were analyzed. We studied 6,096 patient-unique episodes of bacteremia, of which,
2,722 (45.3%) were nosocomial and 523 (9.2%) involved children less than 18 years of age. The overall incidence of bacteremia
episodes has increased over the study years by 39% and the patient mean age by 7.5 years. Gram-negative organisms accounted
for 72% of hospital-acquired cases and 69% of community-acquired cases. There was a substantial increase in the incidence
of nosocomial episodes, predominantly due to Gram-negative isolates, mainly Acinetobacter baumannii, Klebsiella pneumoniae, and Escherichia coli. Increased resistance to broad-spectrum antibiotics was noted among Gram-negative organisms, including quinolones (in K. pneumoniae), imipenem (A. baumannii and P. aeruginosa), piperacillin-tazobactam (K. pneumoniae), and amikacin (A. baumannii and P. aeruginosa). Increased resistance to oxacillin among coagulase-negative staphylococci was also noted. The all-cause mortality rates
showed a significant rise. The patient age, intensive care unit (ICU) stay, and hospital acquisition were independently associated
with mortality. We describe an increase in the incidence and resistance of Gram-negative organisms causing bacteremia and
concomitant ageing of the patients with bacteremia. Similar patterns have been reported from other localities, and are of
real concern. 相似文献
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E. Koren A. Lazarovitch M. Baratz M. Loewenthal M. Solowiejczyk 《Annals of surgery》1974,180(2):198-202
Two cases of Gardner's syndrome in one family are presented. The father presented all three stigmas of the syndrome, while in the daughter no osseous manifestations were found. In the first patient, the diagnosis was made only after the second abdominal operation, when a mesenteric fibrous mass was seen. In the second case, the intestinal polyposis was clinically suspected, considering the hereditary aspects of this syndrome, and the episode of bloody diarrhea presented by this patient. Both patients were treated by subtotal colectomy with ileo-rectal anastomosis. Both of them presented fibrous tumors after the abdominal operation (the father after six years and the daughter after one year). The authors stress the importance of postoperative followup for the detection of fibrous masses that may appear due to the surgical stimulus. The literature on Gardner's syndrome is reviewed and summarized. 相似文献
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