全文获取类型
收费全文 | 752篇 |
免费 | 59篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 15篇 |
妇产科学 | 7篇 |
基础医学 | 109篇 |
口腔科学 | 4篇 |
临床医学 | 98篇 |
内科学 | 85篇 |
皮肤病学 | 13篇 |
神经病学 | 144篇 |
特种医学 | 11篇 |
外科学 | 40篇 |
综合类 | 6篇 |
一般理论 | 2篇 |
预防医学 | 106篇 |
眼科学 | 1篇 |
药学 | 129篇 |
中国医学 | 2篇 |
肿瘤学 | 37篇 |
出版年
2023年 | 7篇 |
2022年 | 14篇 |
2021年 | 35篇 |
2020年 | 23篇 |
2019年 | 25篇 |
2018年 | 30篇 |
2017年 | 17篇 |
2016年 | 18篇 |
2015年 | 19篇 |
2014年 | 26篇 |
2013年 | 44篇 |
2012年 | 57篇 |
2011年 | 43篇 |
2010年 | 28篇 |
2009年 | 18篇 |
2008年 | 43篇 |
2007年 | 37篇 |
2006年 | 50篇 |
2005年 | 54篇 |
2004年 | 47篇 |
2003年 | 45篇 |
2002年 | 48篇 |
2001年 | 21篇 |
2000年 | 12篇 |
1999年 | 17篇 |
1998年 | 14篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1993年 | 3篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1984年 | 1篇 |
1983年 | 3篇 |
1982年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有811条查询结果,搜索用时 15 毫秒
1.
2.
3.
Clio Mamalaki Marianna Murdjeva Mauro Tolaini Trisha Norton Phillip Chandler Alain Townsend Elizabeth Simpson Dimitris Kioussis 《Clinical & developmental immunology》1995,4(4):299-315
Influenza nucleoprotein (NP)-specific T-cell receptor transgenic mice (F5) were crossed
with transgenic mice expressing the cognate antigenic protein under the control of the H-
2Kb promoter. Double-transgenic mice show negative selection of thymocytes at the
CD4+8+TCR10 to CD4+8+TCRhi transition stage. A few CD8 T cells, however, escape clonal
deletion, and in the peripheral lymphoid organs of these mice, they exhibit low levels of
the transgenic receptor and upregulated levels of the CD44 memory marker. Such cells do
not proliferate upon exposure to antigen stimulation in vivo or ex vivo, however, they can
develop low but detectable levels of antigen-specific cytotoxic function after stimulation
in vitro in the presence of IL-2. 相似文献
4.
Smyth LA Ardouin L Williams O Norton T Tybulewicz V Kioussis D 《European journal of immunology》2002,32(12):3386-3394
Interactions of T cells with MHC plus peptide in the peripheral lymphoid system are important for their survival. In this study we investigated further the molecular consequences of such interactions using F5 TCR transgenic mice and peptides previously shown to induce either negative or positive selection in the thymus. Following TCR ligation with the negatively selecting agonist peptide, mature CD8(+) cells proliferated and up-regulated the activation marker CD69. Interestingly, ligation of this TCR with MHC molecules loaded with high concentrations of the positively selecting peptide also resulted in the aforementioned changes, but with slower kinetics. Analysis of the biochemical changes that occur following stimulation with these peptides showed that phosphorylation of key signaling molecules, such as ZAP-70, CD3zeta, Vav, SLP-76, LAT, and ERK-1 and 2, could be detected after exposure to agonist but not antagonist peptide. Confocal microscopy, however, revealed infrequent phosphorylation 'patches' at the site of contact between T cells and APC presenting the antagonist peptide. Our data suggest that peptides capable of inducing positive selection in the thymus can be recognized by mature T cells and cause proliferation, up-regulation of CD69 and accumulation of phosphorylated proteins at the immunological synapse with low efficiency; however no phosphorylation of signaling molecules can be detected using conventional biochemical assays. 相似文献
5.
We reviewed consecutive patients (n = 12) at McLean Hospital from 1990 through 1991 treated with the combination of the atypical antipsychotic agent clozapine and electroconvulsive therapy (ECT). There were no adverse effects. Three patients had a marked clinical improvement, one a moderate response, four a minimal response, two minimal to no response, and two no response. Using daily doses of up to 550 mg clozapine, this combination appears to be safe, and may be useful in some patients with treatment-refractory psychosis. 相似文献
6.
7.
8.
9.
10.