Usefulness of Intraprocedural Pulmonary Venous Flow for Predicting Recurrent Mitral Regurgitation and Clinical Outcomes After Percutaneous Mitral Valve Repair With the MitraClip

Objectives

The aim of this study was to determine the prognostic value of pulmonary venous (PV) flow during MitraClip implantation.

High incidence of cardiorespiratory deterioration in patients receiving cemented hip hemiarthroplasty for femoral neck fracture

BACKGROUND: Anesthesia for patients who undergo surgery for femoral neck fractures can be associated with severe cardiopulmonary complications. METHODS: We retrospectively studied 361 consecutive patients who underwent surgery for femoral neck fractures. Dividing patients into three groups according to type of surgery-hip hemiarthroplasty (n=134), compression hip screw (n=123) or gamma nail (n=104)--we calculated the incidences of cardiorespiratory deterioration during anesthesia and examined factors associated with it. RESULTS: Among hemiarthroplasty patients, six (4.5%) encountered cardiorespiratory deterioration; four (3.0%) experienced profound hypotension, bradycardia or cardiac arrest immediately after implantation of the bone cement or insertion of the prosthesis into the femoral bone; and two (1.5%) developed hypoxia and angina pectoris during the late phase of surgery. Patients who underwent compression hip screw or gamma nail had no cardiorespiratory deterioration. No difference was found in patient characteristics or type of anesthesia used among the three surgery groups. Time of surgery and amount of blood loss both were significantly greater in patients undergoing hemiarthroplasty. CONCLUSIONS: The surgical techniques selected for hip hemiarthroplasty, which is associate with an increase in intramedullary pressure, may be a significant risk factor for cardiorespiratory deterioration from anesthesia in patients undergoing surgery for femoral neck fracture.     

Usefulness of preoperative computed tomography findings for airway management in patients with acute odontogenic infection: a retrospective study

Odontology - Odontogenic infection is more likely to affect the airway and interfere with intubation than non-odontogenic causes. Although anesthesiologists predict the difficulty of intubation and...     

Substrate specificity of HMRZ-86 for β-lactamases,including extended-spectrum β-lactamases (ESBLs)

HMRZ-86 was designed as a new chromogenic cephalosporin to detect extended-spectrum β-lactamases (ESBLs) and similar evolved β-lactamases, such as metallo-β-lactamases, derepressed AmpC, and extended oxacillinase. We report here our investigation of the kinetic parameters of several types of β-lactamases to show the enzymatic characteristics of HMRZ-86. The Michaelis constant (K _m values of HMRZ-86 for ESBLs were twice to three and half times as high as those of nitrocefin, and the maximum velocity (Vmax) was one-fifth that of nitrocefin. The K _m and Vmax of HMRZ-86 for AmpC were both smaller than those of nitrocefin. The kinetic parameters of HMRZ-86 for metallo β-lactamase (MBL) were very variable, depending on the type of buffer solution used and the concentration of zinc ions. For MBL, the K _m values of HMRZ-86 were higher than those of nitrocefin, but the Vmax values were almost the same as those of nitrocefin. Although the chemical structure of HMRZ-86 is similar to that of nitrocefin, we think the enzymatic reactivities of the two entities for β-lactamases are very different.     

Inhibitory effects of magnoshinin and magnosalin, compounds from "Shin-i" (Flos magnoliae), on the competence and progression phases in proliferation of subcultured rat aortic endothelial cells.

Anti-proliferative effects of magnoshinin and magnosalin derived from "Shin-i" (Flos magnoliae) were investigated using subcultured endothelial cells (EC) of rat aorta. The inhibitory effects of magnoshinin were 2-fold greater at 10 micrograms/ml than that of magnosalin on the increase in cell number when EC were stimulated by 5% fetal bovine serum. In the 3H-thymidine incorporation monitored at 3 hr-intervals, magnoshinin (0.1-3 micrograms/ml) prolonged the starting time of DNA synthesis and reduced the rate of incorporation into EC. Magnosalin (0.3-3 micrograms/ml) reduced only the incorporation rate. These results suggest that magnoshinin inhibits both the competence phase and progression phase, but magnosalin preferentially inhibits the progression phase in EC proliferation.