全文获取类型
收费全文 | 58573篇 |
免费 | 5929篇 |
国内免费 | 95篇 |
专业分类
耳鼻咽喉 | 707篇 |
儿科学 | 1610篇 |
妇产科学 | 1427篇 |
基础医学 | 8768篇 |
口腔科学 | 1322篇 |
临床医学 | 7514篇 |
内科学 | 11003篇 |
皮肤病学 | 725篇 |
神经病学 | 4943篇 |
特种医学 | 2011篇 |
外国民族医学 | 1篇 |
外科学 | 7886篇 |
综合类 | 1043篇 |
一般理论 | 61篇 |
预防医学 | 6325篇 |
眼科学 | 913篇 |
药学 | 4589篇 |
中国医学 | 81篇 |
肿瘤学 | 3668篇 |
出版年
2022年 | 496篇 |
2021年 | 1080篇 |
2020年 | 690篇 |
2019年 | 1087篇 |
2018年 | 1239篇 |
2017年 | 921篇 |
2016年 | 1085篇 |
2015年 | 1190篇 |
2014年 | 1566篇 |
2013年 | 2310篇 |
2012年 | 3238篇 |
2011年 | 3271篇 |
2010年 | 1900篇 |
2009年 | 1654篇 |
2008年 | 2858篇 |
2007年 | 2869篇 |
2006年 | 2793篇 |
2005年 | 2729篇 |
2004年 | 2582篇 |
2003年 | 2460篇 |
2002年 | 2369篇 |
2001年 | 1672篇 |
2000年 | 1661篇 |
1999年 | 1453篇 |
1998年 | 723篇 |
1997年 | 596篇 |
1996年 | 506篇 |
1995年 | 522篇 |
1994年 | 493篇 |
1993年 | 450篇 |
1992年 | 1157篇 |
1991年 | 1078篇 |
1990年 | 1054篇 |
1989年 | 968篇 |
1988年 | 891篇 |
1987年 | 915篇 |
1986年 | 881篇 |
1985年 | 900篇 |
1984年 | 726篇 |
1983年 | 615篇 |
1982年 | 447篇 |
1981年 | 364篇 |
1980年 | 373篇 |
1979年 | 592篇 |
1978年 | 454篇 |
1977年 | 370篇 |
1976年 | 374篇 |
1974年 | 384篇 |
1973年 | 340篇 |
1972年 | 340篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
1.
2.
James A. Akingbasote Alison J. Foster Ian Wilson Sunil Sarda Huw B. Jones J. Gerry Kenna 《Archives of toxicology》2016,90(4):853-862
Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN?) mice exhibit normal hepatic and extrahepatic biotransformation enzyme activities when compared to wild-type (WT) mice, but express no functional hepatic cytochrome P450 activities. When incubated in vitro with [14C]-diclofenac, liver microsomes from WT mice exhibited extensive biotransformation to oxidative and glucuronide metabolites and covalent binding to proteins was also observed. In contrast, whereas glucuronide conjugates and a quinone-imine metabolite were formed when [14C]-diclofenac was incubated with HRN? mouse liver, only small quantities of P450-derived oxidative metabolites were produced in these samples and covalent binding to proteins was not observed. Livers from vehicle-treated HRN? mice exhibited enhanced lipid accumulation, bile duct proliferation, hepatocellular degeneration and necrosis and inflammatory cell infiltration, which were not present in livers from WT mice. Elevated liver-derived alanine aminotransferase, glutamate dehydrogenase and alkaline phosphatase activities were also observed in plasma from HRN? mice. When treated orally with diclofenac for 7 days, at 30 mg/kg/day, the severities of the abnormal liver histopathology and plasma liver enzyme findings in HRN? mice were reduced markedly. Oral diclofenac administration did not alter the liver histopathology or elevate plasma enzyme activities of WT mice. These findings indicate that HRN? mice are valuable for exploration of the role played by hepatic P450s in drug biotransformation, but poorly suited to investigations of drug-induced liver toxicity. Nevertheless, studies in HRN? mice could provide novel insights into the role played by inflammation in liver injury and may aid the evaluation of new strategies for its treatment. 相似文献
3.
4.
5.
6.
7.
8.
9.
T. Wu L. G. Trahair M. J. Bound C. F. Deacon M. Horowitz C. K. Rayner K. L. Jones 《Diabetic medicine》2015,32(5):595-600
10.
David M. Presby Michael C. Rudolph Vanessa D. Sherk Matthew R. Jackman Rebecca M. Foright Kenneth L. Jones Julie A. Houck Ginger C. Johnson Janine A. Higgins P. Darrell Neufer Robert H. Eckel Paul S. MacLean 《Diabetes》2021,70(4):867
Moderate weight loss improves numerous risk factors for cardiometabolic disease; however, long-term weight loss maintenance (WLM) is often thwarted by metabolic adaptations that suppress energy expenditure and facilitate weight regain. Skeletal muscle has a prominent role in energy homeostasis; therefore, we investigated the effect of WLM and weight regain on skeletal muscle in rodents. In skeletal muscle of obesity-prone rats, WLM reduced fat oxidative capacity and downregulated genes involved in fat metabolism. Interestingly, even after weight was regained, genes involved in fat metabolism were also reduced. We then subjected mice with skeletal muscle lipoprotein lipase overexpression (mCK-hLPL), which augments fat metabolism, to WLM and weight regain and found that mCK-hLPL attenuates weight regain by potentiating energy expenditure. Irrespective of genotype, weight regain suppressed dietary fat oxidation and downregulated genes involved in fat metabolism in skeletal muscle. However, mCK-hLPL mice oxidized more fat throughout weight regain and had greater expression of genes involved in fat metabolism and lower expression of genes involved in carbohydrate metabolism during WLM and regain. In summary, these results suggest that skeletal muscle fat oxidation is reduced during WLM and regain, and therapies that improve skeletal muscle fat metabolism may attenuate rapid weight regain. 相似文献