全文获取类型
收费全文 | 1146篇 |
免费 | 73篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 51篇 |
妇产科学 | 13篇 |
基础医学 | 148篇 |
口腔科学 | 33篇 |
临床医学 | 85篇 |
内科学 | 212篇 |
皮肤病学 | 18篇 |
神经病学 | 47篇 |
特种医学 | 193篇 |
外国民族医学 | 1篇 |
外科学 | 175篇 |
综合类 | 51篇 |
预防医学 | 79篇 |
眼科学 | 12篇 |
药学 | 56篇 |
中国医学 | 4篇 |
肿瘤学 | 51篇 |
出版年
2023年 | 4篇 |
2022年 | 7篇 |
2021年 | 20篇 |
2020年 | 12篇 |
2019年 | 10篇 |
2018年 | 21篇 |
2017年 | 15篇 |
2016年 | 26篇 |
2015年 | 22篇 |
2014年 | 32篇 |
2013年 | 62篇 |
2012年 | 54篇 |
2011年 | 40篇 |
2010年 | 58篇 |
2009年 | 65篇 |
2008年 | 48篇 |
2007年 | 48篇 |
2006年 | 42篇 |
2005年 | 35篇 |
2004年 | 26篇 |
2003年 | 27篇 |
2002年 | 32篇 |
2001年 | 28篇 |
2000年 | 23篇 |
1999年 | 29篇 |
1998年 | 36篇 |
1997年 | 38篇 |
1996年 | 36篇 |
1995年 | 37篇 |
1994年 | 25篇 |
1993年 | 21篇 |
1992年 | 13篇 |
1991年 | 16篇 |
1990年 | 14篇 |
1989年 | 23篇 |
1988年 | 17篇 |
1987年 | 12篇 |
1986年 | 16篇 |
1985年 | 13篇 |
1984年 | 14篇 |
1983年 | 17篇 |
1982年 | 15篇 |
1981年 | 15篇 |
1980年 | 22篇 |
1979年 | 9篇 |
1978年 | 8篇 |
1976年 | 8篇 |
1975年 | 7篇 |
1969年 | 2篇 |
1968年 | 2篇 |
排序方式: 共有1231条查询结果,搜索用时 15 毫秒
1.
Immunohistochemical and molecular analysis of PI3K/AKT/mTOR pathway in esophageal carcinoma
下载免费PDF全文
![点击此处可从《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Georgia Levidou Dimitrios Theodorou Nikolaos V. Michalopoulos Efstratios Patsouris Angelica A. Saetta 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(8):639-647
Among the numerous signaling pathways involved in tumorigenesis, PI3K‐AKT‐mTOR is a key one that regulates diverse cellular functions. However, its prognostic value in esophageal carcinoma remains unclear. In our study, we examined the immunohistochemical expression of phosphorylated (p‐) AKT, mTOR, p70S6K and 4E‐BP1 along with the mutational status of PIK3CA and AKT1 genes by High Resolution Melting Analysis and Pyrosequencing in 44 esophageal carcinomas. The results were correlated with the clinicopathological characteristics of the patients in an effort to define their possible prognostic significance. Total p‐mTOR cytoplasmic expression, assessed in 10 random areas, was positively correlated with tumor stage (Kruskal–Wallis ANOVA, I/II vs III/IV, p = 0.0500). Μoreover, maximum p‐mTOR cytoplasmic immunoexpression, estimated in hot spot areas, was positively associated with tumor grade (Mann–Whitney U test, I/II vs III, p = 0.0565). Interestingly, p‐4E‐BP1 immunoreactivity was negatively correlated with tumor histological grade (Mann–Whitney U test, I/II vs III, p = 0.0427). No mutation was observed in exons 9 and 20 of PIK3CA gene and in exon 4 of AKT1 gene. In conclusion, our findings depict the presence of activated PI3K/AKT/mTOR pathway in esophageal cancer bringing forward p‐mTOR and p‐4E‐BP1 for their potential role in esophageal carcinogenesis. Additional studies are warranted to validate our findings. 相似文献
2.
3.
4.
5.
E MOLKE JENSEN K. A. THIESSEN AA. CHRISTENSEN 《Acta anaesthesiologica Scandinavica》1986,30(2):109-110
The effect of 4 mg oral naloxone on preoperative gastric volume and pH of gastric aspirate was studied in a double-blind, randomized study. Twenty patients received 10 ml of naloxone (4 mg) mixed with 10 ml of orange juice, and 20 patients received 10 ml of isotonic saline mixed with 10 ml of orange juice, 2 h before surgery. Gastric content was obtained immediately after intubation of the trachea. No significant difference in gastric volume and pH of gastric aspirate was found between the two groups. It is concluded that naloxone does not affect gastric emptying and gastric acid secretion to a degree great enough to protect against aspiration of gastric contents into the lungs. 相似文献
6.
7.
8.
9.
10.