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1.
In developing countries, like Indonesia, apheresis is still a relative new procedure. Nowadays, therapeutic apheresis procedures are performed in the field of hematology and neurology, especially in the teaching hospitals in Indonesia. Therapeutic apheresis procedure, that is, leukocytapheresis, therapeutic plasma exchange (TPE), and thrombocytapheresis are already performed. In the period 2009–2013, 204 apheresis procedures in 137 patients to reduce the leukocytes, 72 TPE procedures in 17 patients, and 14 thrombocyte reductions were performed in the Sardjito hospital, Yogyakarta, Indonesia. In the future, to improve the therapeutic apheresis implementation, it is important to increase the insurance coverage and also should be considered to introduce the apheresis medicine into the curriculum of appropriate physician programs in Indonesia. Especially in Indonesia, a lot of efforts are still being needed to improve implementation of therapeutic apheresis. J. Clin. Apheresis 30:139–140, 2015. © 2014 Wiley Periodicals, Inc. 相似文献
2.
Budipitojo T Sasaki M Matsuzaki S Cruzana MB Iwanaga T Kitamura N Yamada J 《Archives of histology and cytology》2003,66(4):337-346
Gastrin-releasing peptide (GRP) has been proposed as a novel regulatory peptide in the reproductive tract. We previously demonstrated that GRP immunoreactivities are found predominantly in the uterine gland epithelial cells of nonpregnant and pregnant cows. The present study focused on the distribution of GRP immunoreactivity and the expression of GRP mRNA in the bovine endometrium during the estrous cycle. Tissues were collected from 21 uterine horns and bodies during the estrous cycle. RT-PCR showed the expected GRP mRNA fragments (284 bp) in the tissues from all stages of the cycle. In situ hybridization results ascertained the expression of the GRP mRNA in the uterine gland epithelial cells and superficial epithelial cells of the endometrium. Positive staining of GRP immunoreactivity in the uterine gland epithelial cells was detected in both the uterine horn and body from all stages of the cycle. In metestrus and diestrus stages, GRP was also detected in the superficial epithelial cells of horn, but not in the body. The degrees of GRP mRNA expression and intensities of GRP immunoreactivity in the endometrium increased from proestrus to diestrus stages. These findings suggest that GRP may be important both in the endometrial remodeling during the estrous cycle and in the implantation and development of blastocysts. 相似文献
3.
Hani Susianti Lydiana Parmadi Novi Khila Firani Ungky Agus Setyawan Teguh Rahayu Sartono 《Journal of clinical laboratory analysis》2021,35(6)
BackgroundThe prevalence of fungal infection (FI) in developing countries is high, but the diagnosis of FI is still challenging to determine, so it is needed evaluation of biomarkers other than microbiological culture, because the culture has low sensitivity, high cost, not available in every laboratory and needs a long time. The detection of human galactomannan Aspergillus antigen (GAL) and 1,3‐beta‐D‐glucan (BDG) on the fungal cell wall could be the promising biomarkers for fungal infection. Neutropenia, lymphopenia and CD4T cells in the immunocompromised patients are essential factors, but these cell associations with BDG and GAL levels have not been evaluated yet. The study aimed to evaluate GAL and BDG for detecting fungal infection and their association with total leucocyte count, neutrophil, monocyte, lymphocyte and CD4T cells.MethodA cross‐sectional study was conducted among 86 patient with suspected FI. Fungal infection established using EORTC/MSG criteria. Serology test performed using ELISA. Leucocyte cells were measured using a haematology autoanalyser, and CD4T cells were analysed using BD FACSPresto. Statistical analysis obtained using Spearman''s correlation coefficient, ROC curve analysis and 2 × 2 contingency table.ResultsSerum Galactomannan and BDG had a significant correlation with CD4T cells and total lymphocyte count (p < 0.05). The cut‐off OD GAL >0.3 had sensitivity 54.6%, specificity 87.5% and AUC 0.71; meanwhile, the BDG cut‐off >115.78 pg/ mL had sensitivity 71.2%, specificity 52.4% and AUC 0.63 for detecting fungal infection.ConclusionsThe immunocompromised patients can undergo GAL for determining the diagnose of FI. The lower the CD4T cells and total lymphocyte count, the higher the GAL and BDG serum levels. 相似文献
4.
Nur Indah Fajar Mukti Teguh Ariyanto Wahyudi Budi Sediawan Imam Prasetyo 《RSC advances》2021,11(58):36782
The separation of CO2/CH4 can be enhanced by impregnating porous carbon with iron oxide. Dispersion of iron oxide is one of the critical factors which supports the separation process performance. Iron oxide dispersion can be enhanced by enriching the oxygen functional groups on the carbon surface. This study investigates three distinct oxidation processes: oxidation with a 10% H2O2 solution, ozonation with distilled water, and ozonation with a 10% H2O2 solution. The research steps included the following: (i) oxidation, (ii) impregnation of iron oxide followed by calcination, (iii) material characterization, and (iv) material performance analysis. Materials were characterized using N2 sorption analysis, X-ray diffraction analysis (XRD), scanning electron microscopy-energy dispersive X-ray spectroscopy analysis (SEM-EDX), and Fourier transform infrared analysis (FT-IR). Iron oxide was well dispersed on the carbon surface, as evidenced by the elemental mapping of materials. In addition, the oxygen functional groups increased significantly in the range of 28.6–79.7% following the oxidation process, as indicated by the elemental component using SEM-EDX analysis. The impregnation of iron oxide on oxidized carbon ozonated with distilled water (COA–Fe) obtained a maximum CO2 uptake capacity of 3.0 mmol g−1 and CO2/CH4 selectivity increased by up to 190% at a temperature of 30 °C and pressure of 1 atm. Furthermore, the enhancement of CO2/CH4 separation up to 1.45 times was the best performance achieved by COA–Fe. Thus, improving iron oxide dispersion on oxidized carbon surfaces has a potential application in CO2/CH4 separation.The separation of CO2/CH4 can be enhanced by impregnating porous carbon with iron oxide. 相似文献
5.
Alyaa Al-Khateeb Mohd K Zahri Mohd S Mohamed Teguh H Sasongko Suhairi Ibrahim Zurkurnai Yusof Bin A Zilfalil 《BMC medical genetics》2011,12(1):40
Background
Familial hypercholesterolemia is a genetic disorder mainly caused by defects in the low-density lipoprotein receptor gene. Few and limited analyses of familial hypercholesterolemia have been performed in Malaysia, and the underlying mutations therefore remain largely unknown. 相似文献6.
Peter C Levendag David N Teguh Peter Voet Henri van der Est Inge Noever Wilhelmus J M de Kruijf Inger-Karine Kolkman-Deurloo Jean-Briac Prevost Johan Poll Paul I M Schmitz Ben J Heijmen 《Radiotherapy and oncology》2007,85(1):64-73
PURPOSE/OBJECTIVE: To assess the relationship between the radiation therapy (RT) dose received by the muscular components of the swallowing (sw) apparatus and - dysphagia related - quality of life (QoL) in oropharyngeal cancer. MATERIALS/METHODS: Between 2000 and 2005, 81 patients with SCC of the oropharynx were treated by 3DCRT or IMRT, with or without concomitant chemotherapy (CHT); 43 out of these 81 patients were boosted by brachytherapy (BT). Charts of 81 patients were reviewed with regard to late dysphagia complaints; 23% experienced severe dysphagia. Seventeen patients expired. Fifty-six out of 64 (88%) responded to quality of life (QoL) questionnaires; that is, the Performance Status Scales of List, EORTC H&N35, and the M.D. Anderson Dysphagia Inventory. The superior (scm), middle (mcm), and inferior constrictor muscle (icm), the cricopharyngeus muscle and the inlet of the esophagus, are considered of paramount importance for swallowing. The mean dose was calculated in the muscular structures. Univariate analysis and multivariate analysis were performed using the proportional odds model. RESULTS: Mean follow-up was 18 months (range 2-34) for IMRT, and 46 months for 3DCRT (range 2-72). At 3-years, a LRC of 84%, DFS of 78% and OS of 77% were observed. A significant correlation was observed between the mean dose in the scm and mcm, and severe dysphagia complaints (univariate analysis). A steep dose-effect relationship, with an increase of the probability of dysphagia of 19% with every additional 10 Gy, was established. In the multivariate analysis, BT (dose) was the only significant factor. CONCLUSION: A dose-effect relationship between dose and swallowing complaints was observed. One way to improve the QoL is to constrain the dose to be received by the swallowing muscles. 相似文献
7.
Van Khanh Tran Teguh Haryo Sasongko Dang Diem Hong Nguyen Thi Hoan Vu Chi Dung Myeong Jin Lee Gunadi Yasuhiro Takeshima Masafumi Matsuo Hisahide Nishio 《Pediatrics international》2008,50(3):346-351
Background: The SMN1 gene is now recognized as a spinal muscular atrophy (SMA)-causing gene, while SMN2 and NAIP have been characterized as a modifying factor of the clinical severity of SMA. Gene dosage of SMN2 is associated with clinical severity of SMA. But the relationship between gene dosage of NAIP and clinical severity of SMA remains to be clarified, although complete deletion of NAIP is frequent in type I patients.
Methods: To evaluate the contribution of the SMN2 and NAIP gene dosages to SMA, quantitative real-time polymerase chain reaction was used to measure copy numbers of SMN2 and NAIP in 34 Vietnamese SMA patients lacking SMN1 (13 type I, 11 type II and 10 type III patients).
Results: The SMN2 copy number in type I patients was significantly lower than that in type II–III patients, which was compatible with the previous reports. In contrast, 25 out of 34 patients had only zero or one copy of NAIP , while 50 out of 52 controls had two or more copies. For NAIP (+) genotype, six out of 13 type I patients, eight out of 11 type II patients and six out of 10 type III patients carried one NAIP copy.
Conclusions: The SMN2 copy number was related to the clinical severity of SMA among Vietnamese patients. The presence of one NAIP copy, that is, heterozygous NAIP deletion, was common in Vietnamese SMA, regardless of clinical phenotype. 相似文献
Methods: To evaluate the contribution of the SMN2 and NAIP gene dosages to SMA, quantitative real-time polymerase chain reaction was used to measure copy numbers of SMN2 and NAIP in 34 Vietnamese SMA patients lacking SMN1 (13 type I, 11 type II and 10 type III patients).
Results: The SMN2 copy number in type I patients was significantly lower than that in type II–III patients, which was compatible with the previous reports. In contrast, 25 out of 34 patients had only zero or one copy of NAIP , while 50 out of 52 controls had two or more copies. For NAIP (+) genotype, six out of 13 type I patients, eight out of 11 type II patients and six out of 10 type III patients carried one NAIP copy.
Conclusions: The SMN2 copy number was related to the clinical severity of SMA among Vietnamese patients. The presence of one NAIP copy, that is, heterozygous NAIP deletion, was common in Vietnamese SMA, regardless of clinical phenotype. 相似文献
8.
Md. Asiful Islam Fahmida Alam Cinzia Cavestro Cornelia Calcii Teguh Haryo Sasongko Roger A. Levy Siew Hua Gan 《Autoimmunity reviews》2018,17(8):755-767
Background
Autoimmunity is believed to play an important causative role in the pathogenesis of epilepsy. There are evidences for the presence of autoantibodies in patients with epilepsy. To date, many studies have assessed the presence of antiphospholipid antibodies (aPLs) in epilepsy patients, though the relationship has been inconclusive.Aims
The aim of this systematic review and meta-analysis was to evaluate the presence of aPLs in epileptic patients as compared to healthy controls.Methods
Five electronic databases (PubMed, Web of Science, Embase, Scopus and Google Scholar) were searched systematically. Study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects model. Quality assessment was carried out by using the modified 9-star Newcastle-Ottawa Scale (NOS). L'Abbé plots were generated to visually inspect heterogeneity while publication bias was evaluated via visualization of contour- enhanced funnel plots, and Begg's and Egger's tests.Results
Based on the inclusion criteria, 14 studies were selected involving 1248 epilepsy patients and 800 healthy controls. The majority of epilepsy was categorised as generalised or partial and none had comorbidity with autoimmune diseases. Significant presence of both anticardiolipin (aCL) antibodies (OR: 5.16, 95% CI: 3.21–8.28, p?<?0.00001) and anti-β2- glycoprotein I (anti-β2-GPI) antibodies (OR: 2.95, 95% CI: 1.07–8.11, p?=?0.04) exhibited comorbid association with epilepsy patients as compared to healthy controls. Subgroup analyses revealed that presence of aCL antibodies was more specifically observed in paediatrics (OR: 4.57, 95% CI: 2.57–8.15, p?<?0.00001) than adults (OR: 4.24, 95% CI: 1.80–10.01, p?=?0.001). The odds of aCL antibody presence was higher in partial epilepsy patients (OR: 7.88, 95% CI: 3.23–19.24, p?<?0.00001) than that of generalised (OR: 3.76, 95% CI: 2.15–6.59, p?<?0.00001) and in Asian epileptic patients (OR: 9.56, 95% CI: 2.69–33.95, p?=?0.0005) than Europeans (OR: 4.35, 95% CI: 2.74–6.92, p?<?0.00001). The presence of anti-β2-GPI antibodies was significant in paediatric (OR: 6.44, 95% CI: 1.39–29.89, p?=?0.02) and African population with epilepsies (OR: 10.59, 95% CI: 1.22–92.25, p?=?0.03). NOS of the majority of the studies (11/14) indicated a high methodological quality. No substantial heterogeneity was observed either from the quantitative analysis or from the L'Abbé plots while no significant publication bias was detected from funnel plots; Begg's and Egger's tests.Conclusion
Since none of the epilepsy subjects exhibited any comorbid autoimmune disorders, significant presence of aCL and anti-β2-GPI antibodies indicate towards their contribution in immune-mediated general pathogenesis of epilepsy. 相似文献9.
The authors suggest a simplification for the current molecular genetic testing of spinal muscular atrophy (SMA). Deletion analysis of SMN1 exon 7 alone may be necessary and sufficient for the diagnosis of SMA. It is based on sole contribution of survival motor neuron 1 (SMN1) exon 7 to SMA pathogenesis. 相似文献
10.
Catalysts comprising nickel supported on SBA-15 were prepared by wet impregnation and co-impregnation methods. Wet impregnation was performed by directly dispersing an Ni(NO3)2·6H2O aqueous solution into SBA-15, whereas in co-impregnation, ethylene glycol (EG) was added to nickel nitrate aqueous solution prior to dispersion into SBA-15. After drying and calcination, NiO/SBA-15w and NiO/SBA-15c were produced. Later, after the reduction process, Ni/SBA-15w and Ni/SBA-15c were obtained. The prepared catalysts were evaluated for the hydrocracking of pyrolyzed α-cellulose. The TEM images revealed that the catalysts prepared by wet impregnation showed inhomogeneous distribution of nickel loading, whereas catalysts prepared by co-impregnation using EG exhibited homogeneous distribution and formed no nickel aggregates. During hydrocracking of pyrolyzed α-cellulose, Ni/SBA-15c with total acidity, nickel loading, particle size, and specific surface area of 7.27 m mol g−1, 5.20 wt%, 3.17 nm, and 310.0 m2 g−1, respectively, exhibited the best catalytic performance compared to other prepared catalysts with 67.35 wt% conversion of liquid product with maximum selectivity in producing 13.09 wt% of 3-methyl-pentane. Moreover, Ni/SBA-15w with total acidity, nickel loading, particle size, and specific surface area of 10.87 m mol g−1, 8.15 wt%, 7.01 nm, and 628.0 m2 g−1, respectively, produced 69.89 wt% liquid product without hydrocarbons. Study of selectivity towards the formation of liquid hydrocarbons was carried out via double step hydrocracking using Ni/SBA-15w, and 18.55 wt% of n-hexane was produced in the liquid product.Ni/SBA-15c catalyst showed excellent catalytic activity, resistance towards coke formation, and selective production of 3-methyl-pentane in the hydrocracking of pyrolyzed α-cellulose. 相似文献