全文获取类型
收费全文 | 4182篇 |
免费 | 350篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 42篇 |
儿科学 | 140篇 |
妇产科学 | 79篇 |
基础医学 | 479篇 |
口腔科学 | 38篇 |
临床医学 | 584篇 |
内科学 | 636篇 |
皮肤病学 | 47篇 |
神经病学 | 615篇 |
特种医学 | 299篇 |
外科学 | 412篇 |
综合类 | 83篇 |
一般理论 | 11篇 |
预防医学 | 539篇 |
眼科学 | 35篇 |
药学 | 241篇 |
中国医学 | 3篇 |
肿瘤学 | 257篇 |
出版年
2024年 | 12篇 |
2023年 | 46篇 |
2022年 | 71篇 |
2021年 | 166篇 |
2020年 | 115篇 |
2019年 | 144篇 |
2018年 | 162篇 |
2017年 | 131篇 |
2016年 | 114篇 |
2015年 | 129篇 |
2014年 | 142篇 |
2013年 | 247篇 |
2012年 | 305篇 |
2011年 | 339篇 |
2010年 | 186篇 |
2009年 | 158篇 |
2008年 | 259篇 |
2007年 | 307篇 |
2006年 | 262篇 |
2005年 | 231篇 |
2004年 | 229篇 |
2003年 | 180篇 |
2002年 | 161篇 |
2001年 | 47篇 |
2000年 | 44篇 |
1999年 | 57篇 |
1998年 | 42篇 |
1997年 | 24篇 |
1996年 | 19篇 |
1995年 | 20篇 |
1994年 | 14篇 |
1993年 | 12篇 |
1992年 | 14篇 |
1991年 | 16篇 |
1990年 | 16篇 |
1989年 | 22篇 |
1988年 | 12篇 |
1987年 | 9篇 |
1986年 | 11篇 |
1985年 | 8篇 |
1984年 | 4篇 |
1983年 | 6篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1977年 | 3篇 |
1974年 | 3篇 |
1969年 | 3篇 |
1968年 | 4篇 |
1962年 | 3篇 |
1958年 | 2篇 |
排序方式: 共有4540条查询结果,搜索用时 31 毫秒
1.
2.
3.
Interaction effects between the 5‐hydroxy tryptamine transporter‐linked polymorphic region (5‐HTTLPR) genotype and family conflict on adolescent alcohol use and misuse 下载免费PDF全文
4.
Katherine A Hillman Tanya M Johnson Paul J D Winyard Geoffrey Burnstock Robert J Unwin Adrian S Woolf 《Experimental nephrology》2002,10(1):34-42
BACKGROUND: Purinergic receptors are cell-surface molecules that bind extracellular nucleotides, notably ATP. The P2X family includes seven nonselective ion channels with one member, P2X(7), implicated in cytolytic pore formation and cell death. MATERIALS AND METHODS: We sought P2X(7) expression in mouse nephrogenesis and cpk/cpk renal cyst growth, conditions in which both proliferation and apoptosis are prominent. RESULTS: P2X(7) immunolocalized to condensed metanephric mesenchyme: both proliferation and apoptosis were detected in this compartment, assessed by proliferating cell nuclear antigen expression and propidium iodide-stained pyknotic nuclei respectively. Later in nephrogenesis, P2X(7) was detected in collecting ducts, a pattern persisting to maturity. A mesenchymal to epithelial shift of P2X(7) expression was also documented in ureter development. In cpk/cpk kidneys, P2X(7)-expressing collecting duct cysts dominated histology from two weeks until four weeks after birth, when animals die from uremia. In polycystic kidneys pyknotic nuclei were rarely identified in P2X(7)-expressing epithelia, but were detected between cysts, consistent with a non-apoptotic role for P2X(7) in cyst enlargement. CONCLUSION: P2X(7) is expressed during normal nephrogenesis and in a model of congenital polycystic kidney disease. Further experiments are necessary to define possible functions of P2X(7) in these settings. 相似文献
5.
6.
Lungiswa L Nkonki Tanya M Doherty Zelee Hill Mickey Chopra Nikki Schaay Carl Kendall 《AIDS research and therapy》2007,4(1):27
Background
The objective of this study was to examine missed opportunities for participation in a prevention of mother-to-child transmission (PMTCT) programme in three sites in South Africa. A rapid anthropological assessment was used to collect in-depth data from 58 HIV-positive women who were enrolled in a larger cohort study to assess mother-to-child HIV transmission. Semi-structured interviews were conducted with the women in order to gain an understanding of their experiences of antenatal care and to identify missed opportunities for participation in PMTCT. 相似文献7.
Marcus P Kennedy Raymond D Coakley Scott H Donaldson Robert M Aris Kathy Hohneker Joel P Wedd Michael R Knowles Peter H Gilligan James R Yankaskas 《Journal of cystic fibrosis》2007,6(4):267-273
BACKGROUND: The impact of infection with Burkholderia gladioli in cystic fibrosis, other chronic airway diseases and immunosuppressed patients is unknown. METHODS: A six-year retrospective review of all patients with B. gladioli infection was performed in a tertiary referral center with cystic fibrosis and lung transplantation programs. In addition, a targeted survey of all 251 lung transplant recipients was performed. Available B. gladioli isolates were analyzed via pulsed field gel electrophoresis. RESULTS: Thirty-five patients were culture positive for B. gladioli, including 33 CF patients. No bacteremia was identified. Isolates were available in 18 patients and all were genetically distinct. Two-thirds of these isolates were susceptible to usual anti-pseudomonal antibiotics. After acquisition, only 40% of CF patients were chronically infected (> or =2 positive cultures separated by at least 6 months). Chronic infection was associated with resistance to > or =2 antibiotic groups on initial culture and failure of eradication after antibiotic therapy. The impact of acquisition of B. gladioli infection in chronic infection was variable. Three CF patients with chronic infection underwent lung transplantation. One post-transplant patient developed a B. gladioli mediastinal abscess, which was treated successfully. CONCLUSIONS: The majority of patients' culture positive for B. gladioli at our center have CF. B. gladioli infection is often transient and is compatible with satisfactory post-lung transplantation outcomes. 相似文献
8.
Mark Sisco MD ; Jerome D. Chao MD ; Injoong Kim MD ; Jon E. Mogford PhD ; Tanya N. Mayadas PhD ; Thomas A. Mustoe MD 《Wound repair and regeneration》2007,15(4):566-571
The Mac-1 integrin is an important mediator of migration and inflammatory activation of neutrophils and monocytes. However, the role of Mac-1 in modulating macrophage emigration and activation and its subsequent impact on cutaneous wound healing have not been fully elucidated. To examine the significance of Mac-1 to murine wound healing, we measured epithelialization and granulation tissue formation in partial-thickness ear wounds and full-thickness head wounds, respectively, in Mac-1-deficient mice. Wounds were histologically analyzed at postwounding days 3, 5, and 7. The gap measured between the leading edges of inward-migrating granulation tissue was significantly increased in knockout mice compared with control animals at day 5 (3.8+/-0.3 vs. 2.6+/-0.5 mm; p<0.001) and day 7 (2.2+/-0.4 vs. 0.96+/-0.73 mm; p=0.005). Epithelial gap measurements were also increased in knockout mice vs. wild-type controls at days 3 (0.62+/-0.02 vs. 0.54+/-0.07 mm; p<0.05) and 5 (0.58+/-0.06 vs. 0.39+/-0.08 mm; p<0.001). Immunohistochemistry showed equal numbers of macrophages in knockout and control wounds. These findings show that Mac-1 is required for normal wound healing but that the attenuation in the deposition of granulation tissue and wound epithelialization in Mac-1 knockout mice is not associated with decreased monocyte migration into the wound. 相似文献
9.
10.
J. O’Byrne S. Eustace M. M. Stephens M. N. M. R. Farahat G. Yanni R. Posten G. S. Panayi S. Sant R. Costello M. Barry J. Hassan C. Feighery B. Bresnihan A. Whelan F. Coakley A. M. de Paor R. B. Reilly E. B. Casey V. J. Tormey G. Kearns K. Gaffney P. J. Freyne M. Callaghan O. FitzGerald D. Veale E. O’Nuallain D. Reen D. Veale M. Farrell O. FitzGerald S. Rogers L. Barnes R. J. Coughlan C. McCarthy M. McDermott D. Hourihane C. O'Morain S. O'Reilly P. Hartley E. Casey L. Clancy F. Mulcahy N. Hall A. Murphy C. Breen D. Kelleher M. Abuzakouk C. O'Farrelly 《Irish journal of medical science》1992,161(6):438-442