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T Misaki S Dokoh T Koh S Shimbo A Hidaka Y Iida K Kasagi J Konishi 《Kaku igaku. The Japanese journal of nuclear medicine》1991,28(2):157-161
In the clinical management of Graves' thyrotoxicosis, one of the most important subject is when to stop antithyroid drugs after achieving an euthyroid state. T3 suppression test and other methods have been used to forecast the outcome after drug cessation, but the results were not always satisfactory. We have attempted to predict remission of Graves' disease by single measurement of early technetium uptake without administration of triiodothyronine. Drugs were discontinued in the seventy-five patients with Graves' disease on maintenance doses of either methimazole or propylthiouracil who showed normalized uptake (4.0% or less). Of 64 patients evaluable after twelve months, 55 (86%) remained euthyroid, 8 relapsed, and 1 became hypothyroid. With its accuracy in prediction of short-term remission comparable or superior to T3 suppression test, this rapid and simple method seemed suitable for routine use in clinical practice. 相似文献
4.
Takuro Yoshikawa Yasuyuki Suzuki Yasuhiro Fujino Keitaro Kakinoki Shiri Li Tadahiro Goto Tomohiro Tanaka Ippei Matsumoto Tetsuya Sakai Yasuki Tanioka Hiroshi Yokozaki Yoshikazu Kuroda 《American journal of transplantation》2005,5(9):2135-2142
Small bowel transplantation (SBT) is associated with a high incidence of infectious complications because of ischemia/reperfusion (I/R) mucosal injury concomitant with potent immunosuppression. In this study, we evaluated whether the cavitary two-layer method (cTLM) could reduce I/R injury and allow early mucosal restoration, particularly after prolonged preservation and transplantation. Canine heterotopic segmental SBT was performed immediately without preservation (group 1), after 24-h preservation in UW solution (group 2) or by the cTLM (group 3). The graft samples were taken 1 h after reperfusion and on days 1, 4 and 7. We assessed graft mucosa with detailed microscopic and electromicroscopic analyses. In Group 3, histological injury and cell apoptosis after transplantation were significantly alleviated and rapidly recovered to a similar level of group 1. The mucosal restoration was morphologically completed within 4 days. In contrast, in group 2, more pronounced mucosal injury and delayed recovery were noted. Crypt cell proliferation activity was well maintained in groups 1 and 3 throughout the experimental period. Our ultrastructural analysis suggested that mitochondrial integrity achieved by the cTLM was a basal mechanism under the prompt mucosal restoration. The cTLM could reduce I/R injury, facilitate mucosal regeneration and restore the nearly normal structure early after SBT. 相似文献
5.
A Ishiguro T Nakahata Y Amano K Koike A Komiyama T Shimbo 《[Rinshō ketsueki] The Japanese journal of clinical hematology》1992,33(1):87-92
The cause of aplastic anemia associated with hepatitis (AAH) is as yet still unknown. There is a supposed relation to the immune mechanisms, however few reports have shown the effects of monocytes on the pathogenesis in the patients with AAH. We have reported a case of a 12-year-old boy with AAH related to cytomegaloviruses, and studied the hemopoietic progenitors. He showed pancytopenia and hypoplasia of the bone marrow on admission to our hospital. The culture studies showed that mononuclear cells (MNC) of the bone marrow produced few hemopoietic colonies in all cell lineages. However, the depletion of adherent cells from the MNC increased numbers of erythroid, neutrophil-macrophage and megakaryocyte colonies. Furthermore, the addition of adherent cells of the peripheral blood suppressed the colony formation in the aforementioned cell lineages by marrow MNC from which adherent cells, phagocytic cells and T-cells were abrogated. The results way suggest that monocytes play some soles in the pathogenesis of aplasia through inhibitor of hemopoiesis. 相似文献
6.
Takuro Katoh 《Nippon Ishinkin Gakkai Zasshi》2006,47(2):63-67
Environments may act as reservoirs for pathogenic fungi, a determinant of the establishment of fungal infection, or an exacerbating factor of disease. In recent years, skin disease caused by geophilic fungi has been decreasing, while case reports of zoonoses from various animals are increasing. Outbreaks of anthropophilic T. tonsurans infection pose a problem to medical mycologists. Tinea pedis is the most common exogenous dermatomycosis in Japan. Although T. rubrum is presumed to be the dominant pathogen of this disease, T. mentagrophytes is detected more frequently from various environments, so far, the reason for this discrepancy has not been fully understood. The latest knowledge about the route of dermatophyte foot infection is as follows: (1) Dermatophyte propagules disseminated from patients may contaminate not only bath-mats but also wood floors, Japanese style mattings, concrete floors, slippers, cushions, etc., and from them adhere to healthy skin. (2) The agar stamping method can easily detect dermatophytes from the skin and the environment. (3) Propagules of T. mentagrophytes can survive for more than three months under certain conditions such as in rubber boots. (4) In order to eliminate dermatophytes gathered in socks and footwear, simple procedures (washing, bathing with hot water, or wiping with a towel) are all effective. (5) Prior application of an antifungal agent promptly eradicates dermatophyte propagules adhering to the skin from the environment. The author also mentioned the possibility of asymptomatic dermatophyte colonization, and the high prevalence of dysgeucia in oral carriers of Candida albicans. 相似文献
7.
Ogata T 《Medical molecular morphology》2005,38(4):243-250
Brush cells are widely distributed in the digestive and respiratory apparatus, but their function is still unknown. Because
brush cells (BC) are found in organs secreting NaHCO3, it was hypothesized that these cells may secrete NaHCO3. To test this possibility, rat common bile duct epithelia were examined by ultrastructural cytochemical methods for localizing
HCO3−, Cl−, and Na+ ions. All three ion precipitates were few in or on BCs of rats without stimulation. Lead carbonate precipitates, which localized
HCO3− ions by the lead nitrate-osmium method, increased markedly on the surface of the microvilli (MV) of BCs after secretin or
meal stimulation, but similar precipitates were few on the luminal surface of principal cells (PCs). Silver chloride precipitates,
which indicate the presence of Cl− ions by the silver-osmium method, increased in the apical cytoplasm and in MV of BCs after secretin or meal stimulation,
but they were few in PCs. Sodium pyroantimonate precipitates, which localize Na+ ions by the potassium pyroantimonate-osmium method, increased on the surface of the MV, along the basolateral membrane, and
in the apical cytoplasm of BCs after secretin or meal stimulation, but they were few in PCs. These results strongly suggest
that BCs may be a significant source of NaHCO3 secretion. 相似文献
8.
Doi A Okano M Akagi H Nishizaki K Taguchi T Murakami T Ohtsuka A 《Anatomical science international / Japanese Association of Anatomists》2003,78(1):62-67
The musk shrew, Suncus murinus, is one of the primitive mammals and has a pair of palatine tonsils. In the present study,
we investigated the blood microvascular architecture of the tonsil in this animal by scanning electron microscopy of corrosion
casts. The paranodular arterioles entered the lymph nodule to form a coarse capillary plexus within the nodule. Some of the
arterioles reached the dome region to give rise to a fine meshwork of dome subepithelial capillaries. This dome subepithelial
capillary network did not show any hairpin or switch-back patterns, as seen in human and rabbit tonsils. Both of the nodular
and dome capillaries were drained into the postcapillary venules in the periphery of the nodular or the paranodular region.
On the surface of these cast venules, oval-shaped indentations were seen corresponding to the luminal surface of the high
endothelial venules. These venules were collected into the large vein at the bottom of the tonsil. The blood vascular architecture
of the musk shrew tonsil is basically the same as those of other mucosa-associated lymphoid tissues in mammals. 相似文献
9.
Horie R Watanabe T Ito K Morisita Y Watanabe M Ishida T Higashihara M Kadin M Watanabe T 《The American journal of pathology》2002,160(5):1647-1654
We previously reported that ligand-independent signaling by highly expressed CD30 in Hodgkin-Reed-Sternberg (H-RS) cells is responsible for constitutive activation of NF-kappa B. In the present study, we characterize the intracellular localization of tumor necrosis factor (TNF) receptor associated factor (TRAF) proteins in H-RS cells. Confocal immunofluorescence microscopy of cell lines derived from H-RS cells and HEK293 transformants highly expressing CD30 revealed aggregation of TRAF2 and TRAF5 in the cytoplasm as well as clustering near the cell membrane. In contrast, TRAF proteins were diffusely distributed in the cytoplasm in cell lines unrelated to Hodgkin's disease (HD) and control HEK293 cells. Furthermore, the same intracellular distribution of TRAF proteins was demonstrated in H-RS cells of lymph nodes of HD, but not in lymphoma cells in lymph nodes of non-Hodgkin's lymphoma. Dominant-negative TRAF2 and TRAF5 suppressed cytoplasmic aggregation along with constitutive NF-kappa B activation in H-RS cell lines. Confocal immunofluorescence microscopy also revealed co-localization of IKK alpha, NIK, and I kappa B alpha with aggregated TRAF proteins in H-RS cell lines. These results suggest involvement of TRAF protein aggregation in the signaling process of highly expressed CD30 and suggest they function as scaffolding proteins. Thus, cytoplasmic aggregation of TRAF proteins appears to reflect constitutive CD30 signaling which is characteristic of H-RS cells. 相似文献
10.