全文获取类型
收费全文 | 99篇 |
免费 | 6篇 |
专业分类
儿科学 | 2篇 |
妇产科学 | 4篇 |
基础医学 | 3篇 |
口腔科学 | 3篇 |
临床医学 | 8篇 |
内科学 | 10篇 |
皮肤病学 | 25篇 |
神经病学 | 5篇 |
特种医学 | 1篇 |
外科学 | 9篇 |
综合类 | 4篇 |
预防医学 | 15篇 |
眼科学 | 2篇 |
药学 | 7篇 |
肿瘤学 | 7篇 |
出版年
2023年 | 2篇 |
2022年 | 7篇 |
2021年 | 5篇 |
2020年 | 6篇 |
2019年 | 2篇 |
2018年 | 5篇 |
2017年 | 2篇 |
2016年 | 4篇 |
2015年 | 5篇 |
2014年 | 4篇 |
2013年 | 4篇 |
2012年 | 2篇 |
2011年 | 6篇 |
2010年 | 4篇 |
2008年 | 2篇 |
2007年 | 2篇 |
2006年 | 5篇 |
2005年 | 3篇 |
2004年 | 5篇 |
2003年 | 10篇 |
2002年 | 8篇 |
2001年 | 1篇 |
1980年 | 1篇 |
1979年 | 3篇 |
1978年 | 4篇 |
1977年 | 3篇 |
排序方式: 共有105条查询结果,搜索用时 15 毫秒
1.
2.
Manar M. Obiedallah A.M. Abdel-Mageed Tahani H. Elfaham 《Saudi Pharmaceutical Journal》2018,26(7):909-920
In the present work, the antiglaucoma drug, acetazolamide, was formulated as microsponges in situ gel for ocular drug delivery aiming an improved therapeutic efficacy and reduction in the systemic side effects of oral acetazolamide. The microsponges were prepared by the quasi emulsion solvent diffusion method and were incorporated into 25% pluronic F-127 in situ gel. Ethyl cellulose polymer in different proportions with drug was used to prepare the microsponges. Different parameters were evaluated to select the best formulation. The formula S2 with drug to polymer ratio (2:1) showed high entrapment efficiency of about 82% and mean particle size of about 10?µm with polydispersity index (PDI) of 0.22, which are suitable characters for ocular delivery. The in situ gels were evaluated for physicochemical properties (pH, gelling capacity, gelation time and rheological properties) and in vivo studies. S2 formulation showed higher therapeutic efficacy compared to free drug in gel. It was non irritant to the rabbit's eye. These results indicated that acetazolamide microsponges in situ gel have potential ability for ophthalmic delivery. 相似文献
3.
Ichthyosis follicularis (IF) is a very rare neurocutaneous, X-linked recessive condition affecting the skin, hair, eyes, and central nervous system (CNS). This report describes a child with facial dysmorphism, mental retardation, psychomotor delay, congenital alopecia of the scalp, eyebrows, and eyelashes, and extensive spiny follicular papules. A skin biopsy specimen showed the characteristic absence of sebaceous glands. We also reviewed the literature on this very rare entity. Additional findings observed in our patient, including hepatosplenomegaly, undescended testicles, and ptosis, have not been reported before. 相似文献
4.
5.
6.
7.
8.
Fixed drug eruption (FDE) is a common cutaneous reaction which may be seen in reaction to several medications. The usual etiologic agents associated with FDE are phenazones, sulfonamides, and tetracyclines. Often the causative agent is made out from the patients history; in some cases, oral challenge or topical testing may be required. The pathophysiology of FDE is unclear. Cell-mediated, rather than humoral immunity is thought to be involved. Herein we report a case of FDE in a daughter and father. 相似文献
9.
10.
Cutaneous signs play a significant role in clinical medicine. Signs have often been named after the initial observer. They may indicate either dermatologic or systemic illness and aid the examiner in diagnosis and relevant investigations. Some are specific, some have been described in other conditions, and few have lost their relevance. Most of the signs are related to the pathogenesis of the disease but the cause of some is not clear. 相似文献