HPLC-MS Method for Simultaneous Quantitative Determination of an Innovative Russian Gestagen and its Metabolites in Rat and Rabbit Blood Sera

Pharmaceutical Chemistry Journal - An HPLC-MS method for simultaneous quantitative determination of a novel gestagenic pharmaceutical and two of its metabolites in rat and rabbit blood sera was...     

Heart rate of operators with various levels of stress-tolerance]

The paper presents results of the investigation with 8 male subjects 25 to 36 y.o. attesting the existence of relation between stress tolerance evidenced from the data about tracking function during extended continuous wakefulness and the sympathetic activity assessed by heart rate values. Based on there results, the higher stress tolerance, the lower baseline sympathicotonia and the stronger sympathetic reactions to adequate stimuli.     

Effects of the consequences of the Chernobyl accident on the child's body]

Overall 1580 children from the regions with unsafe radiation situation were examined comprehensively at different times after the accident. The data obtained were correlated to the results of examining 610 children of the control group. The basic group children manifested a higher incidence of diverse alterations on the part of many organs and systems, which was accompanied by an increase of free radical processes signs of destabilization of cellular membranes, activation of blood cell metabolism, suppression of the T cell component of immunity in the presence of vegetovascular dysfunction. A tendency was noted toward normalization of these alterations seen over time after the accident. No clear-cut dose-effect dependence was found.     

The strain features of the HIV-1 circulating in the USSR based on data from a study of its properties in cell cultures]

Both variants of HIV-1 reported in the literature: slow/low and rapid/high types, were detected among the strains isolated from the subjects examined in 4 foci of HIV-1 infection in the south of the RSFSR and Byelorussia. All the 17 strains isolated in the southern RSFSR foci belonged to the slow/low type and had a low and unstable replication potential in donor peripheral blood mononuclear cells and in MT-4 cell line. All of them were isolated from subjects with asymptomatic infection and from children with initial clinical manifestations of the disease. Only one strain isolated in Byelorussia belonged to the rapid/high type. Its replicative activity was very similar to that of the classical HIV-1--HTLV-IIIB strain. Long-term (up to 7 months) propagation of slow/low strains did not result in any increase of their replicative activity. The capacity to form syncytia was found not only in the rapid/high type strains but also in the majority of slow/low strains under study.     

Quantitative Determination of the Total Content of Flavonoids in the New Phytopreparation Elima

Pharmaceutical Chemistry Journal -     

Quantum-Chemical Modeling of the Process of Drug Adsorption and the Immobilization of Phytocomponents in Medicinal Forms

Pharmaceutical Chemistry Journal -     

Evaluation of the results of reconstructive operations in patients with occlusive diseases of the abdominal aorta and its branches

The article deals with the results of studying regional microcirculation in 550 patients with chronic arterial insufficiency. Radioisotope study of blood flow in the muscles with isotopes 131I or 133Xe before and after muscular exertion, morpho-histological++ study of biopsies from a skeletal muscle, histochemical and ultrastructural study of the microcirculatory channel were carried out. Analysis of the findings made it possible to distinguish, according to the changes in circulation in the tissues, three clinical groups of patients (compensated, subcompensated, and decompensated), to determine the indications and contraindications for various types of reconstructive operations, and to prognosticate with high authenticity the outcome of the disease.