全文获取类型
收费全文 | 1185篇 |
免费 | 74篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 18篇 |
妇产科学 | 52篇 |
基础医学 | 133篇 |
口腔科学 | 24篇 |
临床医学 | 138篇 |
内科学 | 291篇 |
皮肤病学 | 12篇 |
神经病学 | 76篇 |
特种医学 | 53篇 |
外科学 | 174篇 |
综合类 | 4篇 |
一般理论 | 2篇 |
预防医学 | 48篇 |
眼科学 | 132篇 |
药学 | 49篇 |
中国医学 | 2篇 |
肿瘤学 | 49篇 |
出版年
2023年 | 3篇 |
2022年 | 7篇 |
2021年 | 26篇 |
2020年 | 7篇 |
2019年 | 22篇 |
2018年 | 27篇 |
2017年 | 21篇 |
2016年 | 20篇 |
2015年 | 21篇 |
2014年 | 37篇 |
2013年 | 56篇 |
2012年 | 69篇 |
2011年 | 82篇 |
2010年 | 64篇 |
2009年 | 63篇 |
2008年 | 90篇 |
2007年 | 100篇 |
2006年 | 96篇 |
2005年 | 114篇 |
2004年 | 73篇 |
2003年 | 64篇 |
2002年 | 57篇 |
2001年 | 22篇 |
2000年 | 16篇 |
1999年 | 12篇 |
1998年 | 11篇 |
1997年 | 7篇 |
1996年 | 2篇 |
1994年 | 8篇 |
1993年 | 2篇 |
1992年 | 8篇 |
1991年 | 11篇 |
1990年 | 8篇 |
1986年 | 2篇 |
1985年 | 3篇 |
1984年 | 3篇 |
1982年 | 2篇 |
1979年 | 2篇 |
1978年 | 3篇 |
1970年 | 1篇 |
1969年 | 1篇 |
1967年 | 1篇 |
1966年 | 1篇 |
1965年 | 5篇 |
1964年 | 1篇 |
1963年 | 1篇 |
1962年 | 3篇 |
1961年 | 2篇 |
1960年 | 1篇 |
1959年 | 1篇 |
排序方式: 共有1269条查询结果,搜索用时 15 毫秒
1.
Antegrade interlocking nailing of humeral shaft fractures 总被引:5,自引:0,他引:5
George Petsatodes Dimitrios Karataglis Pericles Papadopoulos John Christoforides John Gigis John Pournaras 《Journal of orthopaedic science》2004,9(3):247-252
The results of 39 humeral shaft fractures (37 patients) treated with antegrade locked nailing using a Russell–Taylor nail were reviewed. There were 30 acute fractures, 6 fractures malaligned in a hanging cast or brace, and 3 pathological fractures. Patient age ranged from 26 to 80 years (average, 59.7 years) and average follow-up was 25.7 months (range, 6–48 months). Fracture union was achieved in 92.3% of our cases, while shoulder function was excellent or good in 87.2% of cases. Antegrade locked nailing offers a dependable solution for the treatment of humeral shaft fractures, especially in polytrauma patients and cases of segmental or pathological fractures. Far less satisfactory results were obtained in comminuted fractures of the proximal third in the humerus, especially in osteoporotic patients, and we therefore advocate caution with the use of intramedullary nailing in this type of fracture. Certain technical aspects such as avoiding nailing the fracture in distraction, properly countersinking the tip of the nail, and achieving adequate fixation stability have been found to be of paramount importance to reduce the incidence of delayed union/non-union rate and to obtain better functional results from the shoulder joint. 相似文献
2.
Lactobacillus johnsonii La1 attenuates Helicobacter pylori-associated gastritis and reduces levels of proinflammatory chemokines in C57BL/6 mice 总被引:3,自引:0,他引:3
Sgouras DN Panayotopoulou EG Martinez-Gonzalez B Petraki K Michopoulos S Mentis A 《Clinical and diagnostic laboratory immunology》2005,12(12):1378-1386
In clinical settings, Lactobacillus johnsonii La1 administration has been reported to have a favorable effect on Helicobacter pylori-associated gastritis, although the mechanism remains unclear. We administered, continuously through the water supply, live La1 to H. pylori-infected C57BL/6 mice and followed colonization, the development of H. pylori-associated gastritis in the lamina propria, and the levels of proinflammatory chemokines macrophage inflammatory protein 2 (MIP-2) and keratinocyte-derived cytokine (KC) in the serum and gastric tissue over a period of 3 months. We documented a significant attenuation in both lymphocytic (P=0.038) and neutrophilic (P=0.003) inflammatory infiltration in the lamina propria as well as in the circulating levels of anti-H. pylori immunoglobulin G antibodies (P=0.003), although we did not observe a suppressive effect of La1 on H. pylori colonizing numbers. Other lactobacilli, such as L. amylovorus DCE 471 and L. acidophilus IBB 801, did not attenuate H. pylori-associated gastritis to the same extent. MIP-2 serum levels were distinctly reduced during the early stages of H. pylori infection in the La1-treated animals, as were gastric mucosal levels of MIP-2 and KC. Finally, we also observed a significant reduction (P=0.046) in H. pylori-induced interleukin-8 secretion by human adenocarcinoma AGS cells in vitro in the presence of neutralized (pH 6.8) La1 spent culture supernatants, without concomitant loss of H. pylori viability. These observations suggest that during the early infection stages, administration of La1 can attenuate H. pylori-induced gastritis in vivo, possibly by reducing proinflammatory chemotactic signals responsible for the recruitment of lymphocytes and neutrophils in the lamina propria. 相似文献
3.
4.
Pournaras S Slavakis A Polyzou A Sofianou D Maniatis AN Tsakris A 《Journal of clinical microbiology》2001,39(2):779-781
Between January and December 1999, in Hippokration General Hospital, Thessaloniki, Greece, a large proportion of the methicillin-resistant Staphylococcus aureus isolates (34.4%) exhibited susceptibility to virtually all alternative non-beta-lactam antibiotics, including tobramycin. Twenty-five of them were selected randomly for further testing; all belonged to a unique genotype and were characterized as heterogeneously resistant to oxacillin. The aadD gene, encoding tobramycin resistance, failed to be amplified in all cases, indicating absence of the gene or the entire plasmid pUB110 from the mec DNA. 相似文献
5.
Pseudo-outbreak of imipenem-resistant Acinetobacter baumannii resulting from false susceptibility testing by a rapid automated system 总被引:2,自引:0,他引:2
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Tsakris A Pantazi A Pournaras S Maniatis A Polyzou A Sofianou D 《Journal of clinical microbiology》2000,38(9):3505-3507
Introduction of the Vitek GNS-506 susceptibility testing cards in the Hippokration General Hospital, Thessaloniki, Greece, resulted in an apparently high prevalence of imipenem-resistant Acinetobacter baumannii. When 35 of these isolates were further tested by disk diffusion, broth microdilution, and agar dilution assays, 32 were imipenem sensitive by all tests and three were sensitive or intermediate, depending on the method. The pseudoresistant acinetobacters did not form a genetically homogeneous group. It is suggested that the detection of imipenem-resistant A. baumannii isolates by this system should be confirmed by an additional susceptibility test. 相似文献
6.
Hans-Heiner Kramer Michael Sommer Spyros Rammos Otto Krogmann 《European journal of pediatrics》1995,154(9):700-707
This study reports our experience with low-dose prostaglandin E1 (PGE1) treatment of 91 newborns with ductus dependent congenital heart disease (CHD). PGE1 efficacy, side-effects as well as the cardiovascular and respiratory profile of the patients were analysed. PGE1 doses > 0.02 g/kg per minute were used for only 5.3% of the total 23 656 h of treatment. The mean systolic blood pressures did not differ from the normal mean for patients with cyanotic CHD, while the diastolic values were lowered. Respiratory support was required only during 13.7% of the total treatment time. Apnoeas occurred in 21 (38%) of the 55 spontaneously breathing infants, who all had a cyanotic CHD. The incidence of apnoeas was lower during treatment with doses < 0.01 g/kg per minute. 相似文献
7.
Pournaras S Tsakris A Mandraveli K Faitatzidou A Douboyas J Tourkantonis A 《Occupational medicine (Oxford, England)》1999,49(7):423-426
Between July 1990 and June 1996, 284 exposures to infectious material were reported by 247 health care workers (HCWs) at AHEPA University Hospital, Thessaloniki, Greece, representing an overall rate of 2.4% reported injuries per 100 HCWs/year. Nurses reported the highest rates of incidents (3.0%) and in all but one working group women exhibited higher injury rates per year than male HCWs. Young workers (21-30 years old) were primarily affected in incidents (P < 0.001). Needles were the most common implement causing injury (60.6%) and resheathing of used needles as well as garbage collection were common causes of injury. None of the HCWs seroconverted in exposures where immune status to blood-borne pathogens was estimated. Efforts by the infection control committee need to be more intense, in order to increase the rate of reported staff injuries. This will facilitate identification of unsafe practices and provide more adequate preventive measures. 相似文献
8.
Age-related macular degeneration (AMD) is a common cause of legal blindness in the developed countries in people older than 50 years of age. AMD complicated by choroidal neovascular membranes (CNV) accounts for 12% of AMD, but for 88% of legal blindness cases. Because of the progressive aging of the population, it is expected that AMD will be one of the greater public health problems in ophthalmology in the first half of the next century. Laser photocoagulation remains the only proven treatment for CNV in AMD, but unfortunately, is applicable only to a minority of patients presenting with CNV in AMD. Photodynamic therapy (PDT) is a new experiment treatment for CNV that combines the application of low-intensity light with a photosensitizing agent in the presence of oxygen to produce tissue effects. It uses the noninvasive potential of the laser light to cause a nonthermal localized chemotoxic reaction and obtain highly selective occlusion of the neovascular channels, with sparing of the overlying photoreceptors. Animal studies showed that PDT accounts for the effective closure of experimentally induced CNV. Phase I-II clinical studies showed that PDT using BPD can safely stabilize leakage from CNV in a majority of patients for up to 3 months. Phase III clinical studies to assess the long term prognosis of PDT-treatment of CNV in AMD are ongoing. 相似文献
9.
Keiko Yamanaka Nikolaos V. Sofikitis Ikuo Miyagawa Yasuhisa Yamamoto Toshiko Toda Spyros Antypas Dimitrios Dimitriadis Manami Takenaka Koji Taniguchi Katsuhiko Takahashi Sanae Tsukamoto Hiroshi Kawamura Martin Neil 《Journal of assisted reproduction and genetics》1997,14(1):55-62
Purpose: Our objective was to apply ooplasmic round spermatid nuclear injections for the treatment of nonobstructive azoospermia.
Materials: Participants were nine azoospermic men who had previously undergone diagnostic testicular biopsy. Spermatogenetic arrest
was diagnosed at the round spermatid stage (n=6) or primary spermatocyte stage (n=3). A second (therapeutic) testicular biopsy
was performed and round spermatid nuclei were recovered from all the participants.
Results: Forty-nine mature oocytes were successfully injected with nuclei and then cultured for 72 hr. Twenty-four embryos were transferred
to nine women. No pregnancy was achieved.
Conclusions: Round spermatids can be recovered from therapeutic testicular biopsy material of men negative for round spermatids in previous
routine diagnostic testicular biopsy specimens. Round spermatid nuclear injections may play a role in the treatment of nonobstructive
azoospermia. 相似文献
10.
Anyfanti Panagiota Gavriilaki Eleni Pyrpasopoulou Athina Triantafyllou George Triantafyllou Areti Chatzimichailidou Sofia Gkaliagkousi Eugenia Aslanidis Spyros Douma Stella 《Clinical rheumatology》2016,35(5):1411-1411
Clinical Rheumatology - 相似文献