全文获取类型
收费全文 | 2719篇 |
免费 | 244篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 115篇 |
妇产科学 | 58篇 |
基础医学 | 398篇 |
口腔科学 | 32篇 |
临床医学 | 321篇 |
内科学 | 451篇 |
皮肤病学 | 16篇 |
神经病学 | 298篇 |
特种医学 | 228篇 |
外科学 | 403篇 |
综合类 | 138篇 |
一般理论 | 1篇 |
预防医学 | 226篇 |
眼科学 | 20篇 |
药学 | 162篇 |
肿瘤学 | 101篇 |
出版年
2021年 | 28篇 |
2020年 | 28篇 |
2019年 | 38篇 |
2018年 | 38篇 |
2017年 | 26篇 |
2016年 | 29篇 |
2015年 | 29篇 |
2014年 | 39篇 |
2013年 | 79篇 |
2012年 | 113篇 |
2011年 | 102篇 |
2010年 | 92篇 |
2009年 | 81篇 |
2008年 | 124篇 |
2007年 | 117篇 |
2006年 | 122篇 |
2005年 | 111篇 |
2004年 | 119篇 |
2003年 | 99篇 |
2002年 | 95篇 |
2001年 | 70篇 |
2000年 | 70篇 |
1999年 | 56篇 |
1998年 | 52篇 |
1997年 | 38篇 |
1996年 | 55篇 |
1995年 | 56篇 |
1994年 | 30篇 |
1993年 | 37篇 |
1992年 | 56篇 |
1991年 | 32篇 |
1990年 | 58篇 |
1989年 | 71篇 |
1988年 | 60篇 |
1987年 | 50篇 |
1986年 | 67篇 |
1985年 | 76篇 |
1984年 | 56篇 |
1983年 | 47篇 |
1982年 | 33篇 |
1981年 | 26篇 |
1980年 | 27篇 |
1979年 | 38篇 |
1978年 | 22篇 |
1977年 | 27篇 |
1976年 | 33篇 |
1975年 | 21篇 |
1974年 | 23篇 |
1973年 | 21篇 |
1968年 | 20篇 |
排序方式: 共有2971条查询结果,搜索用时 31 毫秒
1.
2.
OBJECTIVE: This study was designed to investigate potential areas of practice for the clinical laboratory scientist (CLS) and to propose a graduate curriculum to prepare the practitioner for an advanced level of practice. DESIGN: Meta-analysis of PharmD, physician assistant, physical therapy, and nurse practitioner curricula focusing on academic and clinical advanced practice was used to develop an educational model and curriculum for a professional doctorate in clinical laboratory science (CLS). MAIN OUTCOME MEASURE: (1) New educational model for CLS advanced practice; (2) A proposed curriculum for a Doctorate of Clinical Laboratory Science degree. RESULTS: A new curriculum model was adapted from established healthcare educational models. CONCLUSION: Although there is a need for a baccalaureate degree in CLS there is also a role for expanded education and responsibilities for CLS practitioners. The CLS Advanced Practitioner design focuses on moving students from the baccalaureate level to the doctoral level and prepares the individual to become an integral part of the healthcare team. 相似文献
3.
B Gerdts AFPM Vloemans RW Kreis 《Journal of the European Academy of Dermatology and Venereology》2007,21(6):781-788
BACKGROUND: Toxic epidermal necrolysis (TEN) is a severe and potentially fatal drug reaction characterized by an extensive skin rash with blisters and exfoliation, frequently accompanied by mucositis. The wounds caused by TEN are similar to second-degree burns and severe cases may involve large areas of skin loss. OBJECTIVES: Analysis of our results in patients with TEN and evaluation of the variety of therapeutic interventions that has been studied and suggested in TEN. PATIENTS/METHODS: Retrospective analysis of 19 consecutive patients with TEN treated in our burns centre between 1989 and 2004. RESULTS: Immediate withdrawal of any potentially fatal drug, maximum supportive care, and a restricted and tailored antibiotic, medical and surgical treatment regimen confined mortality to 21%, whereas prognosis scores like APACHE II and SCORTEN predicted mortality of 22 and 30%, respectively. A positive contribution of selective digestive decontamination is suggested but has yet to be established. CONCLUSIONS: Because of a potentially fatal outcome, fast referral of a patient suspected of TEN to a specialized centre (mostly a burns unit or specialized dermatology centre) for expert wound management and tailored comprehensive care is strongly advised and contributes to survival. 相似文献
4.
5.
6.
Monica Conciatori Christopher J Stodgell Susan L Hyman Melanie O'Bara Roberto Militerni Carmela Bravaccio Simona Trillo Francesco Montecchi Cindy Schneider Raun Melmed Maurizio Elia Lori Crawford Sarah J Spence Lucianna Muscarella Vito Guarnieri Leonardo D'Agruma Alessandro Quattrone Leopoldo Zelante Daniel Rabinowitz Tiziana Pascucci Stefano Puglisi-Allegra Karl-Ludvig Reichelt Patricia M Rodier Antonio M Persico 《Neuropsychopharmacology》2004,55(4):413-419
BACKGROUND: The HOXA1 gene plays a major role in brainstem and cranial morphogenesis. The G allele of the HOXA1 A218G polymorphism has been previously found associated with autism. METHODS: We performed case-control and family-based association analyses, contrasting 127 autistic patients with 174 ethnically matched controls, and assessing for allelic transmission disequilibrium in 189 complete trios. RESULTS: A, and not G, alleles were associated with autism using both case-control (chi(2) = 8.96 and 5.71, 1 df, p <.005 and <.025 for genotypes and alleles, respectively), and family-based (transmission/disequilibrium test chi(2) = 8.80, 1 df, p <.005) association analyses. The head circumference of 31 patients carrying one or two copies of the G allele displayed significantly larger median values (95.0th vs. 82.5th percentile, p <.05) and dramatically reduced interindividual variability (p <.0001), compared with 166 patients carrying the A/A genotype. CONCLUSIONS: The HOXA1 A218G polymorphism explains approximately 5% of the variance in the head circumference of autistic patients and represents to our knowledge the first known gene variant providing sizable contributions to cranial morphology. The disease specificity of this finding is currently being investigated. Nonreplications in genetic linkage/association studies could partly stem from the dyshomogeneous distribution of an endophenotype morphologically defined by cranial circumference. 相似文献
7.
1背景 育龄妇女常见慢性下腹痛,可造成身体损害、情绪忧伤及导致巨大的健康服务费用。美国在这方面的花费超过8亿8千万美元(Mathias 1996)。英国全国数据库的一般性诊治资料显示,慢性下腹痛发病率及流行率与偏头痛、背部痛、哮喘发病率相似(Zondervan 1999)。 相似文献
8.
9.
P A Spence C M Peniston N Mihic T E David A K Jabr D Archer T A Salerno 《The Annals of thoracic surgery》1986,42(1):27-30
There is controversy regarding the optimal management of patients in whom acute papillary muscle rupture develops. This study evaluates the effect of division of the anterolateral papillary muscle on left ventricular (LV) function and compares two methods of treatment--mitral valve replacement (MVR) and mitral valve repair. Thirteen pigs were placed on cardiopulmonary bypass, and interventions were performed in an isolated beating heart preparation. LV function was assessed with a compliant intraventricular balloon at baseline, after division of the anterolateral papillary muscle (Divided), after repair of the divided papillary muscle (Repair), and finally after MVR. Division of the anterolateral papillary muscle caused a significant deterioration in LV function. Function was maintained at this level after mitral valve repair but deteriorated with MVR. Developed pressure measured at baseline was 179 +/- 13 mm Hg; Divided, 148 +/- 11 mm Hg (p less than 0.05 versus baseline); Repair, 149 +/- 15 mm Hg; and MVR, 95 +/- 8 mm Hg (p less than 0.05 versus Divided) at a balloon volume of 20 ml. These results suggest that LV function is impaired by papillary muscle rupture. Repair of the ruptured papillary muscle is associated with better LV function than is MVR. 相似文献
10.
From its introduction in 1847, chloroform proved to be a potent anaesthetic
agent and over the next 50 yr its use became widespread. However, in 1912
the Committee on Anaesthesia of the American Medical Association stated
that they were concerned with the occurrence of delayed chloroform
poisoning in a number of cases. This conclusion was based on case reports
and experimental animal data. However, subsequent studies and reported
series of chloroform anaesthesia in humans have suggested a lower incidence
of clinically significant liver injury. In this article we have
investigated this discrepancy by analysing the published clinical data
relating chloroform anaesthesia to liver damage.
相似文献