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Markos Markou Rodopi Sotiropoulou Sempachedin Perente IoannaTriada Kougioumtzi Soultana Foutzitzi Paschalis Chatzipantelis Sotirios Botaitis 《Clinical Case Reports》2022,10(2)
Anomalies of the appendix are rare, and one of the rarest is the double appendixes. Most anomalies of the appendix are observed in adults and are discovered incidentally during surgery that does not primarily involve the appendix. It is usually missed, often with life‐threatening consequences. 相似文献
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K. Tanou A. Koutsokera T. S. Kiropoulos M. Maniati A. I. Papaioannou K. Georga S. Zarogiannis K. I. Gourgoulianis K. Kostikas 《Clinical and experimental allergy》2009,39(3):345-353
Background Accumulating evidence confirms the presence of pan‐airway inflammation in allergic rhinitis patients. Smoking is known to affect the asthmatic airway inflammation. However, no study has evaluated the impact of smoking on airway inflammation of allergic rhinitis patients. Objective The aim of the present study was to evaluate the impact of smoking on inflammatory and oxidative stress biomarkers in patients with seasonal allergic rhinitis, using non‐invasive methods for sample collection. Methods Forty patients with seasonal allergic rhinitis (20 smokers and 20 non‐smokers) and 30 healthy subjects (15 smokers and 15 non‐smokers) were recruited for the study during pollen season. All subjects were submitted to measurement of the fraction of exhaled NO (FeNO), exhaled breath condensate (EBC) collection, nasal lavage collection, pre‐ and post‐ bronchodilation spirometry and metacholine bronchial challenge testing. pH, leukotriene B4 (LTB4) and 8‐isoprostane were determined in EBC and nasal lavage samples. Results Patients with allergic rhinitis presented higher LTB4 and 8‐isoprostane levels in nasal lavage (P<0.0001 for both comparisons), with no significant differences between smokers and non‐smokers. Patients with allergic rhinitis also presented higher LTB4 levels and lower pH in EBC (P<0.001 and P=0.004, respectively), with prominent differences between smokers and non‐smokers (P<0.0001 and P=0.003, for LTB4 and pH, respectively). A significant correlation between nasal lavage and EBC LTB4 values was observed (rs=0.313, P=0.048). Conclusions Patients with allergic rhinitis present increased LTB4 and 8‐isoprostane in their nasal cavity, however, with no significant differences between smokers and non‐smokers. In contrast, smokers with allergic rhinitis present higher LTB4 levels and lower pH in EBC, suggesting that these patients may be more susceptible to the deleterious effects of smoking, compared with non‐smokers. 相似文献
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Nerantzis CE Lefkidis CA Marianou SK Karakoukis NG Koulouris SN 《Anatomical science international / Japanese Association of Anatomists》2003,78(4):223-227
We describe original histologic findings of left ventricle papillary muscle (LVPM) arteries in people under 30 years of age.
We examined 666 samples taken from the tip, mid-portion and base of papillary muscles in 56 males and 55 females, as well
as several samples from the rest of the left ventricle. The number of smooth muscle cells (SMC) in the tunica media of the
LVPM arteries led us to divide the samples examined into three groups: (i) group 1, 355 samples (53%) with a normal number
of SMC and a normal lumen (the number of group 1 samples increased from the tip (21%) to the base (47%)); (ii) group 2, 252
samples (38%) with a mild to moderately increased number of SMC (the number of these samples decreased from the tip (44%)
to the base (22%)); and (iii) group 3, 59 samples (9%) with abundant SMC that were more than twofold greater in size and number
of normal arteries, in contrast with the other two groups. The shape of the SMC in group 3 samples was round and the extremely
narrow, centrally located lumen of these SMCE had a round or oval shape. These changes were restricted only to papillary muscle
arteries and the number of group 3 samples decreased from the tip (63%) to the mid-portion (37%). No inflammatory reaction
or chronic ischemic changes were found in the LVPM arteries and surrounding area. The SMC changes in groups 2 and 3 were found
in subjects aged more than 2 months. These findings will provide anatomists, cardiologists, pathologists and physiologists
with valuable knowledge and will trigger further investigation into the etiology of the structural changes observed and their
evolution with age. 相似文献
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Ossifying fibromyxoid tumor (OFMT) is an uncommon soft tissue neoplasm characterized by a combination of myxoid and/or fibrous stroma with areas of ossification. Although most authors postulate a neuroectodermal origin for this peculiar tumor, there is no agreement in the literature regarding its histogenesis. In this article, we present the immunohistochemical findings of a case of a 39-year-old white male with an OFMT of the soft tissue in the mandibular region. The tumor was positive to S-100 protein, glial fibrillary acidic protein, CD99, CD56 and negative to smooth muscle actin, cytokeratins AE1/AE3, epithelial membrane antigen, and CD68. To the best of our knowledge, this is the first case reported to be positive to CD56 and CD99. Immunoreactivity to these two antibodies, together with reactivity for S-100 protein and glial fibrillary acidic protein, suggests that OFMT is of a neuroectodermal origin. In our opinion, in the absence of reactivity to at least one neuroectodermal marker one should seriously question a diagnosis of OFMT. 相似文献
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Miliaras D Meditskou S Ketikidou M 《Human reproduction (Oxford, England)》2008,23(10):2385; author reply 2385-2385; author reply 2386