排序方式: 共有7条查询结果,搜索用时 15 毫秒
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Purpose
To compare the patterns of retinal nerve fiber layer (RNFL) thickness loss in primary angle-closure glaucoma (PACG) and primary open-angle glaucoma (POAG) using optical coherence tomography (OCT). 相似文献2.
Anita Manassakorn Winai Chaidaroon Somsanguan Ausayakhun Soontaree Aupapong Sopa Wattananikorn 《Japanese journal of ophthalmology》2008,52(6):450-456
Purpose To investigate the distribution of retinal nerve fiber layer (RNFL) and macular retinal thickness measured by optical coherence
tomography (OCT) in a Thai population.
Methods We studied one eye each of 250 healthy subjects [age ≥ 18 years; spherical refractive error within ±6 diopters (D); astigmatism
≤3 D; no ocular pathology]. A complete eye examination, standard automated perimetry, and fast RNFL and macular thickness
measurement by OCT were performed, and a disc photograph was taken. The distributions of both thicknesses, including their
relationship with demographic data, were analyzed.
Results The mean ± SD age of the study population was 44.7 ± 12.2 years. The mean ± SD RNFL thickness was 109.3 ± 10.5 m, which was
10% thicker than that in the OCT normative database. RNFL decreased 2.3 m per decade (P < 0.001). Sex and spherical equivalent were not associated with RNFL thinning. The mean ± SD central foveal thickness was
183.2 ± 1.3 m. The macular thickness in the outer area was significantly thinner than that in the inner area (P < 0.001). The temporal regions were the thinnest among the four quadrants (P < 0.001). Thinning of all macular areas, except the center, was found to be associated with advancing age (P < 0.05).
Conclusions RNFL thickness in the measured Thai population was about 10% thicker than that in the original normative database. Macular
thickness and RNFL thickness in the superior and inferior quadrants decreased with advancing age.
Presented at the 6th International Glaucoma Society Meeting, 28–31 March 2007, Athens, Greece 相似文献
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Jongjaroenprasert W Chanprasertyotin S Butadej S Nakasatien S Charatcharoenwitthaya N Himathongkam T Ongphiphadhanakul B 《Clinical endocrinology》2008,68(4):646-651
Background Genetic predisposition has been suggested to play role in the pathogenesis of thyrotoxic hypokalaemic periodic paralysis (THPP). Objectives In this study, we assessed the differences of single‐nucleotide polymorphisms (SNP) allelic frequency between THPP patients and well‐characterized controls in order to find the susceptibility genetic variants related to THPP using microarray‐based assessments on pooled DNA. Methods Fifty cases of THPP and 50 male hyperthyroid patients without hypokalaemia as controls were recruited. Equal amounts of individual genomic DNA were pooled from each group. Estimated allele frequencies of SNPs were derived by averaging relative allele signal score obtained by Affymetrix GeneChip® Mapping 10K Arrays. Results Sixty‐nine loci that display robust allele frequency differences between THPP and controls were identified. SNP rs750841 (A > T) in intron 3 of the gamma‐aminobutyric acid (GABA) receptor α3 subunit (GABRA3) gene possessed the most significant difference in allele frequency (27% in THPP case and 5% in controls, P = 0·007). Actual allele frequencies obtained from genotyping in each individual were very similar to the estimated frequency from the pools (28% in THPP and 2% in controls, and P = 0·0002). Nearby DNA sequences of GABRA3 were sequenced and an additional two SNPs were found (A > C at exon 1 and G > T of rs12688128). Allele A of rs750841 and allele G of rs12688128 in intron 3 were predominantly found in THPP with significant genetic relative risk of 19 (P < 0·0002; 95%CI 2·4–151·6). Conclusions Whole‐genome scanning on pooled DNA provides an accurate, useful screening tool for elucidating genetic underpinnings of THPP. SNPs at intron 3 of GABRA3 are found to be associated with THPP. 相似文献
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Wanalee Klomjai Benchaporn Aneksan Anuchai Pheungphrarattanatrai Thanwarat Chantanachai Nattha Choowong Soontaree Bunleukhet Paradee Auvichayapat Yongchai Nilanon Vimonwan Hiengkaew 《Annals of physical and rehabilitation medicine》2018,61(5):286-291
Anodal stimulation increases cortical excitably, whereas cathodal stimulation decreases cortical excitability. Dual transcranial direct current stimulation (tDCS; anodal over the lesioned hemisphere, cathodal over the non-lesioned hemisphere) was found to enhance motor learning. The corresponding tDCS-induced changes were reported to reduce the inhibition exerted by the unaffected hemisphere on the affected hemisphere and restore the normal balance of the interhemispheric inhibition. Most studies were devoted to the possible modification of upper-limb motor function after tDCS; however, almost no study has demonstrated its effects on lower-limb function and gait, which are also commonly disordered in stroke patients with motor deficits. In this randomized sham-controlled crossover study, we included 19 patients with sub-acute stroke. Participants were randomly allocated to receive real or sham dual-tDCS followed by conventional physical therapy with an intervention interval of at least 1 week. Dual-tDCS was applied over the lower-limb M1 at 2-mA intensity for 20 min. Lower-limb performance was assessed by the Timed Up and Go (TUG) and Five-Times-Sit-To-Stand (FTSTS) tests and muscle strength was assessed by peak knee torque of extension. We found a significant increase in time to perform the FTSST for the real group, with improvements significantly greater than for the sham group; the TUG score was significantly increased but not higher than for the sham group. An after-effect on FTSTS was found at approximately 1 week after the real intervention. Muscle strength was unchanged in both limbs for both real and sham groups. Our results suggest that a single session of dual-tDCS before conventional physical therapy could improve sit-to-stand performance, which appeared to be improved over conventional physical therapy alone. However, strength performance was not increased after the combination treatment. 相似文献
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Thapinta D Anders RL Mahatnirunkul S Srikosai S 《Issues in mental health nursing》2010,31(12):763-769
The aim of this study was to develop and validate nursing-sensitive indicators for patients hospitalized with depression in Thailand. The initial draft, consisting of 12 categories with 37 subcategories, was then evaluated by experts in the US and Thailand. Hospital records were then utilized to evaluate the feasibility and efficacy of the indicators. The finalized instrument consisted of 11 categories with 43 items with a validity of .98 and internal consistency of .88. This is the first set of indicators developed to evaluate nursing-sensitivity for patients hospitalized with a diagnosis of depression in Thailand. Having nursing indicators for depressed patients provides nurses with concrete tools to evaluate their work with depressed patients, allowing these staff to assess their work in a very specific, methodical, and consistent manner. When problems are discovered, both the staff and administration can work to address these issues through training, procedural changes, and departmental shifts. 相似文献
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Yotsapon Thewjitcharoen Ekgaluck Wanothayaroj Soontaree Nakasatien Sirinate Krittiyawong Ishant Khurana Assam ElOsta Thep Himathongkam 《Clinical Case Reports》2022,10(4)
Kabuki syndrome (KS) is a genetic disorder characterized by distinctive facies, intellectual disability, and multi‐organ anomalies. This case report highlights the importance of clinical recognizable phenotype in patients with diabetes. The development of diabetes should be considered an endocrine complication in KS patients. 相似文献
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