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Bencharit S Schardt-Sacco D Zuniga JR Minsley GE 《The Journal of prosthetic dentistry》2003,90(3):220-224
Florid cemento-osseous dysplasia is an extensive form of periapical cemental dysplasia, which usually involves 1 to 4 posterior areas of the maxilla and mandible. The affected area undergoes changes from normal vascular bone into an avascular cementum-like lesion. The lesion is usually benign; however, treatment of a secondary infection of this lesion can be difficult and complicated. This clinical report describes a rare but aggressive secondary infection of this type, which was successfully treated by a combination of complex surgical and prosthodontic procedures, including dental implant therapy. 相似文献
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Effects of word frequency on recall memory following lorazepam, alcohol, and lorazepam alcohol interaction in healthy volunteers 总被引:1,自引:0,他引:1
Free recall of words has been extensively used in psychopharmacology to assess the effects of CNS-active drugs on memory functions. However, there is a relative lack of information on the impact of word frequency on the subsequent recall of words following the administration of psychoactive drugs. The present double-blind, placebo-controlled, repeated-measures experiment used lorazepam and alcohol to test the effects of word frequency on immediate and delayed word recall in 24 healthy volunteers. One half of the words contained in the lists had a high frequency (HF) of occurrence and the remainder were of low frequency (LF). The results showed that LF words were more sensitive to memory impairment than HF words. However, the more accurate recall of HF words (with respect to LF words) was eliminated when a combination of lorazepam with alcohol was administered. These findings indicate that word frequency has a significant impact on memory and, as such, is a factor to be taken into account when using memory recall tasks to assess the effects of psychoactive drugs on memory. 相似文献
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We performed an abbreviated prospective study of rabies pre-exposure (PREP) vaccination in 109 volunteers. Group 1, the control group, received the conventional 3 intradermal injections on days 0, 7 and 21. Group 2 received one rabies vaccine injection (0.1 ml intradermally) at 2 sites on a single day. Group 3 was given one full ampule intramuscularly. One year later, all 3 groups received booster injections (0.1 ml at 4 sites) intradermally at one time or 2 injections intramuscularly on days 0 and 3. All subjects achieved a vigorous anamnestic antibody response 7 days after the boosters. These data suggest that one time immunization of one full dose intramuscularly or 2 site injections of 0.1 intradermally on a single day are adequate to prime immune memory and obtain an accelerated immune response one year later. 相似文献
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Lo-apirukkul S Jenjittikul T Saralamp P Prathanturarug S 《Journal of natural medicines》2012,66(2):265-270
We studied the effects of explant types, plant growth regulators, and sucrose concentrations on shoot and microrhizome inductions
of Curcuma
comosa Roxb., an important Thai medicinal plant for women’s health. Explant types significantly affected shoot induction of the
plant. The maximum shoot multiplication rate of 11.82 ± 1.03 shoots/responding explant was obtained when culturing terminal
bud explants on semi-solid Murashige and Skoog (MS) medium supplemented with 18.16 μM thidiazuron for 8 weeks. Subsequently,
they were transferred to a semi-solid MS medium without plant growth regulators for 4 weeks. The regenerated shoots produced
roots spontaneously. Rooted plantlets were successfully transferred to the soil. Microrhizome induction was significantly
influenced by sucrose concentrations, but not by 6-benzyladenine (BA). Liquid MS medium with a combination of 17.76 μM BA
and 50 g L−1 sucrose was optimal for microrhizome induction of C. comosa. After 12 weeks of culture, the microrhizome induction rate was 3.36 ± 0.44 microrhizomes/responding explant. Starch accumulation
in microrhizomes increased with higher sugar concentration and with longer duration of culture. The microrhizomes were allowed
to germinate under greenhouse conditions and further developed into normal plants. The protocols established will be used
for the production of uniform plantlets suitable for field plantation for the herbal industry. 相似文献
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Pharmacokinetics of Stavudine and Didanosine Coadministered with Nelfinavir in Human Immunodeficiency Virus-Exposed Neonates 总被引:4,自引:0,他引:4
Chokechai Rongkavilit Pimolrat Thaithumyanon Theshinee Chuenyam Bharat D. Damle Sompop Limpongsanurak Chantana Boonrod Aeumporn Srigritsanapol Elly A. M. Hassink Richard M. W. Hoetelmans David A. Cooper Joep M. A. Lange Kiat Ruxrungtham Praphan Phanuphak 《Antimicrobial agents and chemotherapy》2001,45(12):3585-3590
We evaluated the pharmacokinetics of stavudine (d4T) and didanosine (ddI) in neonates. Eight neonates born to human immunodeficiency virus-infected mothers were enrolled to receive 1 mg of d4T per kg of body weight twice daily and 100 mg of ddI per m(2) once daily in combination with nelfinavir for 4 weeks after birth. Pharmacokinetic evaluations were performed at 14 and 28 days of age. For d4T, on days 14 and 28, the median areas under the concentration-time curves from 0 to 12 h (AUC(0-12)s) were 1,866 and 1,603, ng x h/ml, respectively, and the median peak concentrations (C(max)s) were 463 and 507 ng/ml, respectively. For ddI, on days 14 and 28, the median AUC(0-10)s were 1,573 and 1,562 h x ng/ml, respectively, and the median C(max)s were 627 and 687 ng/ml, respectively. Systemic levels of exposure to d4T were comparable to those seen in children, suggesting that the pediatric dose of 1 mg/kg twice daily is appropriate for neonates at 2 to 4 weeks of age. Levels of exposure to ddI were modestly higher than those seen in children. Whether this observation warrants a reduction of the ddI dose in neonates is unclear. 相似文献
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