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排序方式: 共有222条查询结果,搜索用时 15 毫秒
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Edwards Katie M. Banyard Victoria L. Waterman Emily A. Mitchell Kimberly J. Jones Lisa M. Kollar Laura M. Mercer Hopfauf Skyler Simon Briana 《Prevention science》2022,23(8):1379-1393
Prevention Science - Involving youth in developing and implementing prevention programs to reduce sexual violence (SV) has the potential to improve prevention outcomes. However, there has been... 相似文献
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Jay S. Skyler 《Diabetes》2013,62(11):3656-3657
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Kai J. Jonas Skyler T. Hawk Danny Vastenburg Peter de Groot 《Archives of sexual behavior》2014,43(4):745-753
Men having sex with men (MSM) commonly consume “bareback” pornography, which includes scenes of unprotected anal intercourse. Prior research on human imitative behavior suggests that these media might counteract efforts to promote safe-sex behaviors. To date, no studies have demonstrated a causal link between bareback pornography consumption and reduced safe-sex intentions. Study 1 utilized a correlational design conducted as an online survey. Study 2 was set in an actual MSM sex club, using a 2 × 2 mixed-factorial design to compare type of pornography (unprotected vs. protected anal intercourse) and age of actors (younger vs. older). As the main dependent variable in both studies, participants self-reported their inclinations toward unprotected versus protected intercourse, using a 100-point sliding scale (1 = unprotected, 100 = protected). In Study 1, more attention to unprotected sex acts on actual DVD film covers predicted lower safe-sex intentions, as compared to other elements of the film cover. In Study 2, safe-sex intentions after viewing unprotected-sex films were lower than after viewing protected-sex films. The results provide novel and ecologically valid evidence that “bareback” pornography consumption impacts viewer’s inclinations toward sexual risk-taking by lowering their intentions to use protected sex measures. Suggestions are given as to how these findings can be utilized for purposes of intervention and prevention of STI and HIV infections. 相似文献
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J M Sosenko D B Kubrusly R B Goldberg A M Fournier S L Hsia M T Gadia J S Skyler 《Archives of internal medicine》1986,146(8):1521-1524
We investigated associations of high-density-lipoprotein (HDL) cholesterol, apolipoprotein A-I, and triglyceride levels with hemoglobin A1 (HbA1) and insulin levels in nondiabetic subjects (137 women and 111 men). In women, HDL cholesterol, apolipoprotein A-I, and log-triglyceride values were significantly correlated with those of HbA1 and log-fasting insulin. These univariate associations persisted when age and Quetelet's index were included as covariates in multiple regression analyses. Conversely, univariate associations of HDL cholesterol and log-triglyceride levels with Quetelet's index were diminished by the addition of insulin values to multivariate models. Insulin levels and Quetelet's index were highly correlated. Although there were weaker associations in men, apolipoprotein A-I and HbA1 values were inversely related. These data suggest that HDL cholesterol and apolipoprotein A-I levels are closely linked to glucose metabolism in nondiabetic individuals. 相似文献
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Cefalu WT Skyler JS Kourides IA Landschulz WH Balagtas CC Cheng S Gelfand RA;Inhaled Insulin Study Group 《Annals of internal medicine》2001,134(3):203-207
BACKGROUND: Despite demonstrated benefits, intensive insulin therapy has not gained widespread clinical acceptance for several reasons: Multiple daily injections are inconvenient, adherence is a concern, and the time-activity profile may not mimic normal insulin secretion. As such, alternate means of administering insulin are being evaluated. OBJECTIVE: To assess the efficacy and safety of pulmonary delivery of insulin in type 2 diabetic patients who require insulin. DESIGN: Randomized, open-label, 3-month study consisting of a screening visit, a 4-week baseline lead-in phase, and a 12-week treatment phase. SETTING: General clinical research center and outpatient research clinics. PATIENTS: 26 patients (16 men, 10 women) with type 2 diabetes (average age, 51.1 years; average duration of diabetes, 11.2 years). INTERVENTION: Patients received inhaled insulin before each meal plus a bedtime injection of ultralente insulin, performed home glucose monitoring, and had weekly adjustment of insulin dose; target level for preprandial plasma glucose was 5.55 to 8.88 mmol/L (100 to 160 mg/dL). MEASUREMENTS: Glycemic control (hemoglobin A(1c) level) obtained at baseline and monthly for 3 months. Pulmonary function tests were done at baseline and at the end of the study. RESULTS: Inhaled insulin treatment for 3 months significantly improved glycemic control compared with baseline: Mean hemoglobin A(1c) levels decreased by 0.0071 +/- 0.0072 (0.71% +/- 0.72%). Patients experienced an average of 0.83 mild to moderate hypoglycemic event per month; no severe events were recorded. Patients showed no significant weight gain or change in pulmonary function compared with baseline. CONCLUSIONS: Pulmonary delivery of insulin in type 2 diabetic patients who require insulin improved glycemic control, was well tolerated, and demonstrated no adverse pulmonary effects. Larger-scale studies are ongoing to provide long-term efficacy and safety data. 相似文献
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J S Skyler 《Endocrinology & Metabolism Clinics of North America》2001,30(4):833-856
Diabetic retinopathy and diabetic nephropathy extract an enormous toll on patients with diabetes and an enormous burden on the health care system. With aggressive control of glycemia and blood pressure, coupled with aggressive use of laser photocoagulation and treatment of microalbuminuria, these problems can largely be eliminated. In the future, specific interventions may emerge that will allow interdiction of the pathophysiologic processes that lead to initiation and progression of these microvascular complications. The challenge for the primary care physician and diabetologist is to attain excellent glycemic control and aggressive control of blood pressure, while assuring that every patient has appropriate dilated fundus examinations at least annually, preferably by an ophthalmologist or retinal specialist, and regular screening for microalbuminuria. With such medical management, appropriate intervention can occur to reduce the risk of blindness and renal failure and to lessen the burden from diabetic retinopathy and nephropathy. 相似文献
8.
Bruce A. Perkins MD Nima Soleymanlou PhD Julio Rosenstock MD Jay S. Skyler MD Lori M. Laffel MD Karl-Heinz Liesenfeld Dietmar Neubacher Matthew M. Riggs PhD Curtis K. Johnston PharmD Rena J. Eudy-Byrne PhD Ahmed Elmokadem PhD Jyothis T. George MD Jan Marquard MD Valerie Nock PhD 《Diabetes, obesity & metabolism》2020,22(3):427-433
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Heba?M.?Ismail Ping?Xu Ingrid?M.?Libman Dorothy?J.?Becker Jennifer?B.?Marks Jay?S.?Skyler Jerry?P.?Palmer Jay?M.?Sosenko Type Diabetes TrialNet Study Group 《Diabetologia》2018,61(1):84-92