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排序方式: 共有753条查询结果,搜索用时 15 毫秒
1.
Sandeep Nijhawan Mukul Rastogi Ashish Joshi Atul Shende Manish Tandon Dinesh Singla Amit Mathur Subhash Nepalia Ramesh Roop Rai 《Digestive endoscopy》2007,19(2):80-82
Background: Ingestion of coins is a common clinical problem in children. Many of the coins are ferromagnetic and can be retrieved with the help of a magnet. We describe the use of a novel endoscopic accessory for removing ferromagnetic coins. Material and methods: Two magnet discs of 1.5 cm diameter were joined to a 200 cm steel wire of 0.75 mm thickness with a terminal 5 cm spring. A Teflon tube (160 cm, 7 F) was used along with this instrument as a sleeve. The use of this accessory was analyzed prospectively in subjects presenting with a history of coin ingestion. The time taken for removal of coins, complications during the procedure and failure rate was noted. Effect of the magnet on cardiac rhythm was also noted during the procedure. Results: A total of 55 children (mean age 5.1 ± 2.3 years) with coin ingestion presented over a period of 1 year. Forty‐four coins were ferromagnetic. All ferromagnetic coins were removed successfully. Mean time for removal was 68 ± 22 s. No complications were encountered. Conclusion: The novel magnetic instrument is precise, safe and quick for the removal of ferromagnetic coins under direct vision. 相似文献
2.
Postprostatectomy incontinence in men is a devastating condition impacting the quality of life profoundly. Various types of
male sling procedures have been introduced over the years. The bone-anchored male sling appears to be effective and safe in
intermediate-term follow-up. It is certainly more effective than collagen implant and may provide an alternative treatment
option in patients with mild to moderate incontinence. In the short term, other novel procedures seem promising. In spite
of new technology, the artificial urinary sphincter continues to provide high patient satisfaction and cure rates. 相似文献
3.
Rohit R. Badia Solomon Woldu Hiten D. Patel Nirmish Singla Arnav Srivastava Joseph G. Cheaib Phillip M. Pierorazio Aditya Bagrodia 《Urologic oncology》2021,39(2):136.e19-136.e25
BackgroundThe American Joint Committee on Cancer 8th edition staging guidelines for testicular cancer established a 3 cm cutoff to subclassify stage T1 seminomas (<3 cm = pT1a and ≥3 cm = pT1b). The efficacy of this cutoff in predicting metastatic disease and impact on treatment patterns have not been studied.MethodsWe retrospectively reviewed patients with pT1 testicular seminoma in the National Cancer Database from 2004 to 2016. Receiver operating curves were used to determine the efficacy of the 3 cm tumor cutoff in identifying metastatic disease, and multivariable regression was used to compute the effect of tumor size on the rate of adjuvant therapy among Stage I patients.ResultsA total of 10,134 patients with pT1 seminoma were evaluated. The current size cutoff of 3 cm for subclassification did not exhibit high discrimination in identifying metastatic disease (area under receiver operating curve: 0.546). Surveillance has grown as the preferred treatment after orchiectomy ?32.1% in 2004 to 81.2% in 2015. However, the rate of adjuvant therapy for pT1, Stage I seminomas associated positively with tumor size even with adjustment for year of diagnosis. For tumors above 3 cm, the odds ratio stabilized around 1.9. By using the 3 cm cutoff to guide adjuvant therapy, up to 85% of T1b patients may be overtreated.ConclusionThe 3 cm cutoff for subclassification of Stage I seminoma does not predict metastatic recurrence but is associated with increased receipt of adjuvant therapy. A 3 cm cutoff and the pT1a/b classification may therefore contribute to overtreatment in many young patients with a long life expectancy for whom minimizing adverse effects should be prioritized. 相似文献
4.
5.
Gabriela F. Meresman Rosa I. Barañao A. Tenenbaum J. J. Singla N. R. Neuspiller Lia S. Rumi 《Archives of gynecology and obstetrics》1997,259(3):109-115
The aim of this study was to evaluate and compare the mitogenic effect of peritoneal fluid (PF) from women with mild and severe
endometriosis on the endometrial stromal cell proliferation. Increasing concentrations of PF from women with and without mild
or severe endometriosis were added to primary endometrial stromal cell cultures and3H-thymidine incorporation was used to assess DNA synthesis in these cultures. PF from women with mild endometriosis induced
a statistically significant dose-dependent increase in stromal cell thymidine uptake ranged from 5.8 to 14.5 fold, whereas
PF from women with severe endometriosis produced an average 51% inhibition of stromal cell proliferation of compared with
cells exposed to non-endometriosis PF or exposed to nutrient medium supplemented with 2.5% calf serum alone. PF samples from
patients with stage I endometriosis induced a statistically dose-dependent increase in stromal cell proliferation, whereas
PF from patients with stage IV endometriosis caused a significant inhibition. 相似文献
6.
Sham L. Singla Yogender Singh Kadian Naveen Malhotra Ashish Goyal 《Indian journal of otolaryngology and head and neck surgery》2004,56(2):131-132
Neurilemmoma of the cervical sympathetic chain is a rare nerve tumour. Less than 40 confirmed cases have been reported in
the literature.1 2 Sometimes they can he mistaken as carotid body tumour but usual presentation of these lesions is an asymptomatic
neck mass. Because of the rarity of the tumour we report another case of neurilemmoma arising from cervical sympathetic chain
in a 19 years old male. 相似文献
7.
Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. 总被引:26,自引:0,他引:26
Hesperidin, a bioflavonoid, is an abundant and inexpensive by-product of Citrus cultivation. A deficiency of this substance in the diet has been linked with abnormal capillary leakiness as well as pain in the extremities causing aches, weakness and night leg cramps. No signs of toxicity have been observed with the normal intake of hesperidin or related compounds. Both hesperidin and its aglycone hesperetin have been reported to possess a wide range of pharmacological properties. This paper reviews various aspects of hesperidin and its related compounds, including their occurrence, physical and chemical properties, analysis, pharmacokinetics, safety and toxicity and the marketed products available. A special emphasis has been laid on the pharmacological properties and medicinal uses of these compounds. 相似文献
8.
S Sharma R Sarin U K Khalid N Singla P P Sharma D Behera 《The international journal of tuberculosis and lung disease》2008,12(1):74-80
SETTING: Paediatric Pulmonology Department, TB Institute, New Delhi, India. OBJECTIVE: To evaluate the outcome of the DOTS strategy for paediatric pulmonary tuberculosis (TB). DESIGN: Retrospective analysis of 1098 children. RESULTS: The mean age of the children included in the study was 11.2 years, with more females (61.7%) than males (38.3%). In the 0-5, 6-10 and 11-14 year age groups, the percentage of patients was respectively 18.3%, 26.6% and 55.1%. Patients were registered as new cases (87.7%), relapses (1.9%), failures (1.0%), defaulters (5.0%), transferred in (0.9%) and others (3.5%). Of the total number of cases, 414 were smear-positive and 404 smear-negative, while sputum status was not known for 280 patients. Sputum positivity increased with age. Category I, II and III regimens were started by respectively 50.6%, 10.5% and 38.9% patients. The cure rate was 92.4% (302/327) for new and 92% (80/87) for retreatment cases (chi(2)(1) = 0.02, P = 0.901), but the treatment completion rate was significantly higher for new cases (97%, 636/656) than retreatment cases (53.6%, 15/28) (chi(2)(1) = 100.8, P < 0.001). The overall success rate was 95.4% and 82.6% for new and retreatment cases, respectively (chi(2)(1) = 30.35, P < 0.001). Overall, the rates for default, failure and death in the study were respectively 3%, 1.9% and 1%. CONCLUSION: DOTS appears to be a highly efficacious treatment strategy. 相似文献
9.
Tuberculosis and pregnancy 总被引:1,自引:0,他引:1
Singla R 《The Indian journal of chest diseases & allied sciences》2004,46(4):299; author reply 299-299; author reply 300
10.
Juan I Bastón Rosa I Barañao Analía G Ricci Mariela A Bilotas Carla N Olivares José J Singla Alejandro M Gonzalez Juan C Stupirski Diego O Croci Gabriel A Rabinovich Gabriela F Meresman 《The Journal of pathology》2014,234(3):329-337
Endometriosis is characterized by the presence of endometrial tissue outside the uterus that causes severe pelvic pain and infertility in women of reproductive age. Although not completely understood, the pathophysiology of the disease involves chronic dysregulation of inflammatory and vascular signalling. In the quest for novel therapeutic targets, we investigated the involvement of galectin‐1 (Gal‐1), an endogenous glycan‐binding protein endowed with both immunosuppressive and pro‐angiogenic activities, in the pathophysiology of endometriotic lesions. Here we show that Gal‐1 is selectively expressed in stromal and endothelial cells of human endometriotic lesions. Using an experimental endometriosis model induced in wild‐type and Gal‐1‐deficient (Lgals1?/?) mice, we showed that this lectin orchestrates the formation of vascular networks in endometriotic lesions in vivo, facilitating their ectopic growth independently of vascular endothelial growth factor (VEGF) and the keratinocyte‐derived CXC‐motif (CXC‐KC) chemokine. Targeting Gal‐1 using a specific neutralizing mAb reduced the size and vascularized area of endometriotic lesions within the peritoneal compartment. These results underline the essential role of Gal‐1 during endometriosis and validate this lectin as a possible target for the treatment of disease. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献