全文获取类型
收费全文 | 469篇 |
免费 | 28篇 |
国内免费 | 6篇 |
专业分类
儿科学 | 28篇 |
妇产科学 | 5篇 |
基础医学 | 28篇 |
口腔科学 | 7篇 |
临床医学 | 54篇 |
内科学 | 109篇 |
皮肤病学 | 14篇 |
神经病学 | 5篇 |
特种医学 | 72篇 |
外科学 | 74篇 |
综合类 | 19篇 |
预防医学 | 31篇 |
眼科学 | 15篇 |
药学 | 14篇 |
中国医学 | 1篇 |
肿瘤学 | 27篇 |
出版年
2023年 | 6篇 |
2022年 | 9篇 |
2021年 | 6篇 |
2020年 | 12篇 |
2019年 | 9篇 |
2018年 | 8篇 |
2017年 | 9篇 |
2016年 | 13篇 |
2015年 | 8篇 |
2014年 | 21篇 |
2013年 | 17篇 |
2012年 | 10篇 |
2011年 | 13篇 |
2010年 | 14篇 |
2009年 | 27篇 |
2008年 | 20篇 |
2007年 | 18篇 |
2006年 | 16篇 |
2005年 | 11篇 |
2004年 | 12篇 |
2003年 | 10篇 |
2002年 | 5篇 |
2001年 | 11篇 |
2000年 | 10篇 |
1999年 | 18篇 |
1998年 | 18篇 |
1997年 | 14篇 |
1996年 | 19篇 |
1995年 | 13篇 |
1994年 | 14篇 |
1993年 | 19篇 |
1992年 | 13篇 |
1991年 | 3篇 |
1990年 | 6篇 |
1989年 | 6篇 |
1988年 | 12篇 |
1987年 | 10篇 |
1986年 | 7篇 |
1985年 | 13篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1980年 | 4篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 3篇 |
1975年 | 2篇 |
排序方式: 共有503条查询结果,搜索用时 15 毫秒
1.
2.
3.
4.
青蒿琥酯皮肤擦剂在小鼠和兔体内的药代动力学研究 总被引:1,自引:0,他引:1
将青蒿琥酯溶于苯二甲酸二甲酯,加适量氨酮制成皮肤擦剂。给兔脱毛后,皮肤涂抹此擦剂25mg/kg后,血药浓度达峰时间平均为2 h,峰浓度平均为1.80μg/ml。药物在兔体内平均驻留时间为3.54 h,清除半衰期约为2.46 h。给小鼠脱毛皮肤涂抹擦剂6.7,31.3和71.4 mg/kg,血药浓度在给药后0.5~4 h达高峰,峰浓度分别为0.82,2.05和7.11μg/ml,体内药物平均驻留时间为3.39,2.79及3.54 h,清除半衰期为2.35,1.93及2.45 h。可见,给兔及小鼠皮肤擦剂后,青蒿琥酯吸收良好,血药浓度维持时间较长。 相似文献
5.
Evagelos N Liberopoulos Eleni Papavasiliou George A Miltiadous Marios Cariolou Kostas C Siamopoulos Alexandros D Tselepis Moses S Elisaf 《Peritoneal dialysis international》2004,24(6):580-589
OBJECTIVE: The more atherogenic lipid profile seen in peritoneal dialysis (PD) patients cannot fully explain the increased incidence of atherosclerosis in this population. Oxidative modification of low-density lipoproteins (LDL) is considered to play a central role in the atherogenic process, whereas high-density lipoprotein (HDL) protects LDL from oxidation. On the other hand, it has been suggested that the LDL and HDL of PD patients are more resistant to oxidation than those of control subjects, while PD-HDL equally protects LDL from oxidation compared to control-HDL. Two HDL-associated enzymes have been shown to protect both LDL and HDL from oxidation: paraoxonase (PON1) and HDL-associated platelet-activating factor acetylhydrolase (HDL-PAF-AH). Furthermore, low PON1 activity and high total plasma PAF-AH concentration, which represents mainly the LDL-associated enzyme, have been shown to be independent risk factors for coronary artery events in the general population. However, there are limited data regarding possible alterations of these enzymes in PD patients. The aim of our study was to examine the possible alterations of PON1 and PAF-AH activities in patients undergoing PD. DESIGN: A cross-sectional study. SETTING: A university medical center. PARTICIPANTS: 56 PD patients of Caucasian origin and 86 matched controls were studied. MEASUREMENTS: In all subjects, serum PON1 activity toward paraoxon (paraoxonase) and phenylacetate (arylesterase), as well as total serum and HDL-PAF-AH activities were measured; PON1 genetic polymorphisms known to influence PON1 activity (Q192R and M55L) were determined. RESULTS: The PD patients exhibited significantly increased serum PON1 (paraoxonase) and PON1 (arylesterase) activities compared to controls, regardless of the PON1 polymorphisms or the levels of HDL cholesterol. Additionally, PD patients had significantly elevated activities of total serum PAF-AH and HDL-PAF-AH, independently of the levels of LDL or HDL cholesterol. The ratio of HDL-PAF-AH/ total PAF-AH, which has recently been suggested to be a potential marker of atherogenicity, was decreased in these patients compared to controls. Moreover, no difference in the prevalence of PON1 polymorphisms between PD patients and controls was found. CONCLUSION: The elevated activities of PON1 and HDL-PAF-AH could explain the increased resistance of PD-HDL to oxidation; the higher activity of total PAF-AH and the decreased HDL-PAF-AH/ total PAF-AH ratio could contribute to the increased incidence of atherosclerosis in these patients. 相似文献
6.
7.
8.
9.
10.