A Ro/SS-A auto-antibody positive mother's infant revealed congenital complete atrioventricular block,followed by insulin dependent diabetes mellitus and multiple organ failure

We experienced a congenital complete atrioventricular block infant who was born from a Ro/SS-A antibody positive mother. Ro/SS-A antibody was also found in this baby which was presumed to be mediated by the maternal placenta. Temporary cardiac pacing was required at birth and pacemaker implantation was performed at 9 months. At 11 months of age, the baby fell into shock and experienced multiple organ failure because of diabetes mellitus-induced coma. The association between congenital complete heart block and the Ro/SS-A antibody is well known. However, the accompaniment of insulin-dependent diabetes mellitus has not been reported previously. As the Ro/SS-A antigen appears in the cytoplasm of many tissues, the possibility of an association between Ro/SS-A antibody and diabetes mellitus is difficult to deny. We report this rare case to draw attention to the possibility that babies who are born from an Ro/SS-A antibody positive mother may develop diabetes mellitus as well as congenital complete heart block.     

膨化聚四氟乙烯平片在无张力腹股沟疝修补术的临床应用

目的 探讨平片在腹股沟疝无张力疝修补术中的应用。方法 对我科2003年10-2006年10月收冶的125例腹股沟疝患者采用平片无张力腹股沟疝修补术的疗效进行回顾性分析。结果 所有患者均治愈出院，术后无切口感染，除2例残留疝囊处血肿外无其他不良并发症，随访2个月～36月无复发。结论 平片应用于腹股沟疝的修补，具有易掌握，疗效好，费用低，值得广泛开展应用。     

FD-1冷冻干燥机的研制及生物材料的冷冻干燥

观察自制冷冻干燥机冷冻干燥生物材料的效果。采用 R5 0 2压缩机和制冷剂制成 FD- 1冷冻干燥机。本实验冷冻干燥了胶原海绵、菌种及去纤酶。在冻干箱负载或空载情况下蒸发冷凝器温度均可达到 - 4 5℃ ,小冰箱可达到 - 30℃ ,冻干的胶原海绵具有许多孔洞的结构 ,冻干的菌种和去纤酶性能保持良好。 FD- 1冷冻干燥机适用于生物样品中小批量的冷冻干燥     

对新型农村合作医疗定点医疗机构不规范行为监管的思路探讨

分析了对定点医疗机构进行监管的意义;论述了形成严谨和系统监管思路的重要性;探讨了对定点医疗机构进行监管的具体思路,即首先分析定点医疗机构不规范行为产生的原因、动机及表现形式,然后确定需要监管的目标、范围及重点领域,最后围绕重点领域有针对性的研究监管对策、寻求监管途径和制定监管措施。     

对新型农村合作医疗定点医疗机构监管的途径与程序

根据定点医疗机构不规范行为产生的规律、特点和表现形式,探讨对定点医疗机构监管的途径,即内部监管和外部监管、组织监督和社会监督、专项监管和综合监管、法律、法规、部门规章、行业条例等监管、内部及外部审计等;制定了对定点医疗机构监管的程序,即制定监管计划—实施监管行动—监管信息反馈—奖优罚劣。     

A Case of In-Stent Neoatherosclerosis 10 Years after Carotid Artery Stent Implantation: Observation with Optical Coherence Tomography and Plaque Histological Findings

We report a patient''s case of slow progressive in-stent restenosis 10 years after bare-metal stent implantation to his carotid artery. We treated the patient with an additional stent placement under a distal filter protection device. Optical coherence tomographic assessment and plaque histology during the carotid artery stenting (CAS) revealed atheromatous change at in-stent neointima, which contained lipid-rich plaque and calcification deposits. These findings suggest that in-stent neoatherosclerosis may play an important role in the pathogenesis of very late stent restenosis after CAS.     

一测多评法测定心可宁胶囊中6种蟾蜍二烯内酯类化合物

目的 建立一测多评法同时测定心可宁胶囊中6种蟾蜍二烯内酯类化合物的含量,并验证此方法在心可宁胶囊中应用的可行性和准确性。方法 以华蟾酥毒基为内参物,建立日蟾毒它灵、沙蟾毒精、蟾毒它灵、蟾毒灵和脂蟾毒配基与华蟾酥毒基的相对校正因子。分别采用外标法和一测多评法测定心可宁胶囊中6种蟾蜍二烯内酯类化合物的含量,比较2种方法的结果差异,验证一测多评法的可行性和准确性。结果 日蟾毒它灵、沙蟾毒精、蟾毒它灵、蟾毒灵和脂蟾毒配基与华蟾酥毒基的相对校正因子分别为1.06,0.862,0.897,1.09,0.915;2种方法结果无显著差异。结论 以华蟾酥毒基为内参物建立的相对校正因子重现性好,一测多评法可用于心可宁胶囊中多个蟾蜍二烯内酯类成分的质量评价。     

CD4+CD29+T cells are blamed for the persistent inflammatory response in ulcerative colitis

Ulcerative colitis (UC) is a chronic gastrointestinal disorder eliciting occurrence of colorectal cancer, the third most common human malignancy. The diagnosis of UC is based on clinical symptoms combined with typical findings on endoscopy, radiology, and ultimately pathology. We investigated the variation trend of CD4⁺CD29⁺T cells together with MPO, VCAM-1 in different periods of rat UC model and UC patients. We also evaluated the relationship between CD4⁺CD29⁺T cells and disease severity. UC model was induced by administering DNCB liquid and acetate solution. We found upregulated expression of CD4⁺CD29⁺T cells in both peripheral blood and colon from rats, and a similar trend for MPO and VCAM-1 in colon (P < 0.05); the expression was especially enhanced in UC rats at two weeks after the model was established (P < 0.01). Such upregulation was also indicated in active and remission UC patients as compared to the healthy and enteritis groups (P < 0.05), with the highest expression level detected in the active UC patients (P < 0.01). Pearson correlation analysis showed a positive correlation of CD4⁺CD29⁺T cells in rat and human peripheral blood with DAI score (r_rat = 0.712, r_human = 0.677, P < 0.01), and MPO in colon (r_rat = 0.514, r_human = 0.682, P < 0.05). These results suggest that CD4⁺CD29⁺T cells may act as major effector cell subsets in persistent inflammatory responses for UC and that infiltration into colon inflammation may be induced by the combination of VCAM-1 and CD29.     

A composite carbon-based solid acid-supported palladium catalyst (Pd/C-SO3H) for hydrogenolysis of plant-derived polymeric proanthocyanidins

A composite catalyst, Pd/C-SO₃H, has been prepared to depolymerize plant-derived polymeric proanthocyanidins (PPC). Different reaction conditions were explored and the catalyst was shown to have good performance and recyclability, as well as good thermal and acid–base stability. UV, FTIR and ¹H NMR analyses showed that the depolymerization products (oligomeric proanthocyanidins, OPC) retained a condensed flavanol polyphenol structure and that the basic structural units of the polymers had not been destroyed. The antioxidant activity of the OPC was better than that of the PPC, and also better than that of 2,6-di-tert-butyl-4-methylphenol, which is widely used in industry, including as a food additive. OPC could, therefore, be developed as a commercially useful radical chain-breaking antioxidant. The preparation of Pd/C-SO₃H provides an example of the design and development of a new composite catalyst that has high practical value. The study also provides a new technical route for the depolymerization of PPC and thus makes a useful contribution to the high-value utilization of renewable plant resources.

A composite catalyst, Pd/C-SO₃H, has been prepared to depolymerize plant-derived polymeric proanthocyanidins (PPC).     

医疗公共卫生管理存在的问题及对策

目的：探讨医疗公共卫生管理过程中存在的问题,并提出解决这些相关问题的对策,以供有关部门参考。方法通过调查研究发现,医院在医疗公共卫生管理过程中存在很多问题。结合具体情况,采取有针对性的解决措施。结果解决了医院医疗公共卫生管理过程中存在的问题。结论针对医院医疗公共卫生管理过程中存在的问题,提出了相应的解决对策,进一步改善了医院医疗公共卫生环境,从而能够更好地服务于患者。