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排序方式: 共有59条查询结果,搜索用时 15 毫秒
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dos Reis SB de Oliveira CC Acedo SC Miranda DD Ribeiro ML Pedrazzoli J Gambero A 《Phytotherapy research : PTR》2009,23(3):324-329
Inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis are chronic enteropathies that probably result from a dysregulated mucosal immune response. These pathologies are characterized by oxidative and nitrosative stress, leukocyte infiltration and up-regulation of pro-inflammatory substances. Current IBD treatment presents limitations in both efficacy and safety that stimulated the search for new active compounds. Garcinia cambogia extract has attracted interest due to its pharmacological properties, including gastroprotective effects. In this study, the antiinflammatory activity of a garcinia extract was assessed in TNBS-induced colitis rats. The results obtained revealed that garcinia administration to colitic rats significantly improved the macroscopic damage and caused substantial reductions in increases in MPO activity, COX-2 and iNOS expression. In addition, garcinia extract treatment was able to reduce PGE(2) and IL-1beta colonic levels. These antiinflammatory actions could be related to a reduction in DNA damage in isolated colonocytes, observed with the comet assay. Finally, garcinia extract caused neither mortality nor toxicity signals after oral administration. As such, the antiinflammatory effects provided by the Garcinia cambogia extract result in an improvement of several parameters analysed in experimental colitis and could provide a source for the search for new antiinflammatory compounds useful in IBD treatment. 相似文献
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Mesenteric adipose tissue alterations resulting from experimental reactivated colitis 总被引:1,自引:0,他引:1
Gambero A Maróstica M Abdalla Saad MJ Pedrazzoli J 《Inflammatory bowel diseases》2007,13(11):1357-1364
BACKGROUND: Adipose tissue secretes a large number of hormones that act either locally or at distant sites, modulating immune responses, inflammation, and many endocrine and metabolic functions. Abnormalities of fat in the mesentery have been long recognized in surgical specimens as characteristic features of Crohn's disease; however, the importance of this in chronic inflammatory disease is unknown. Additionally, adipocytes in depots that enclose lymph nodes or other dense masses of lymphoid tissue have many site-specific physiological properties. METHODS: In this study, the alterations of mesenteric and perinodal mesenteric adipose tissue during experimental colitis, induced by repeated intracolonic trinitrobenzene sulfonic acid instillations, were evaluated, focusing on morphological and activity alterations and the adipocytokine production profile. RESULTS: After a 35-day protocol, the colitis animals presented greater mesenteric fat masses despite their lower body weights. Another adipose tissue depot, epididymal adipose tissue, was also evaluated and no change in mass was observed. The mesenteric adipocyte from colitis animals had a reduced diameter, normal PPAR-gamma-2 expression, and higher basal lipolysis and TNF-alpha production when compared to normal rats. Perinodal mesenteric adipocytes present normal diameters, downregulated levels of PPAR-gamma-2, higher basal lipolysis and TNF-alpha, and leptin and adiponectin production. CONCLUSIONS: The findings suggest that mesenteric adipose tissue has a site-specific response during experimental inflammation, where perinodal adipose tissue retains the ability to produce different adipocytokines. These substances may interfere in many lymph node aspects, while mesenteric adipose tissue produces substances that could contribute directly to aggravate the inflammatory process. 相似文献
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Neuropeptides function as peptide neurotransmitters and hormones to mediate cell-cell communication. The goal of this study was to understand how different neuropeptides may be similarly or differentially regulated by protein kinase A (PKA) and protein kinase C (PKC) intracellular signaling mechanisms. Therefore, this study compared the differential effects of treating neuroendocrine chromaffin cells with stimulators of PKA and PKC on the production of the neuropeptides (Met)enkephalin, galanin, somatostatin, NPY, and VIP. Significantly, selective increases in production of these neuropeptides were observed by forskolin or phorbol myristate acetate (PMA) which stimulate PKA and PKC mechanisms, respectively. (Met)enkephalin production was stimulated by up to 2-fold by forskolin treatment, but not by PMA. In contrast, PMA treatment (but not forskolin) resulted in a 2-fold increase in production of galanin and somatostatin, and a 3-fold increase in NPY production. Notably, VIP production was highly stimulated by forskolin and PMA, with increases of 3-fold and 10-15-fold, respectively. Differences in elevated neuropeptides occurred in cell extracts compared to secretion media, which consisted of (i) increased NPY primarily in secretion media, (ii) increased (Met)enkephalin and somatostatin in secretion media (not cell extracts), and (iii) increased galanin and VIP in both cell extracts and secretion media. Involvement of PKA or PKC for forskolin or PMA regulation of neuropeptide biosynthesis, respectively, was confirmed with direct inhibitors of PKA and PKC. The selective activation of neuropeptide production by forskolin and PMA demonstrates that PKA and PKC pathways are involved in the differential regulation of neuropeptide production. 相似文献
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Tatiana M. Sakamoto Andreia A. Canalli Fabiola Traina Carla F. Franco-Penteado Sheley Gambero Sara T.O. Saad Nicola Conran Fernando F. Costa 《Clinical biochemistry》2013
Objectives
Intravascular hemolysis may have important pathophysiological consequences, such as the induction of cellular adhesion and vasculopathy. We compared the adhesive properties of red cells (RBC) and platelets in hereditary spherocytosis (HS), paroxysmal nocturnal hemoglobinuria (PNH) and sickle cell disease (SCD) patients.Design and methods
The adhesion of RBC and platelets, from patients and healthy subjects, was determined using static adhesion assays. RBC surface markers were characterized by flow cytometry and lactate dehydrogenase (LDH), plasma hemoglobin (pHb) and TNF-α were assayed in serum/plasma samples.Results
pHb levels were elevated in all three hemolytic diseases, indicating the incidence of intravascular hemolysis. RBC adhesion and TNF-α were augmented in HS and SCD, but not in PNH. Reticulocyte counts were raised in the three diseases, but were higher in HS and SCD than in PNH; high expressions of CD71, CD36 and CD49d were observed on SCD RBC, while CD71 alone was increased on HS and PNH RBC. Splenectomy was associated with reversals of increased pHb, RBC adhesion, reticulocytes, RBC marker expression and inflammation in HS. In contrast, platelet adhesion was elevated in SCD and PNH, but not HS. Platelet adhesion correlated significantly with serum LDH, but not pHb, in the hemolytic disease cohort; interestingly, LDH did not correlate with reticulocytes or pHb levels.Conclusions
Results indicate that extravascular, rather than intravascular, hemolysis (and ensuing RBC production) may contribute to elevations in RBC adhesive properties in HS and SCD, while mechanisms peculiar to each disease may augment platelet adhesion in SCD and PNH. 相似文献7.
Dr. Joseph F. Sheley Ph.D. Ernest W. Kinchen BA Donald H. Morgan MA David F. Gordon Ph.D. 《Journal of community health》1991,16(2):117-124
Analysis of data obtained through a survey of 415 men in New Orleans, Louisiana, and Rochester, New York, indicates that the transfer of testicular self-examination (TSE) skills from the medical community to the public has been relatively ineffective. Only two of every 100 respondents reported monthly self-examination performed at the correct time and with the proper method. The findings suggest that, until the transfer of self-detection skills is improved, one cannot assess the efficacy of the technology itself. Problems impeding such improvement are reviewed.Joseph F. Sheley, Ph.D., is Associate Professor and Chair Department of Sociology, Tulane University, New Orleans, LA 70118. Ernest W. Kinchen, BA, is a student at Harvard Medical School, 25 Shattuck St., Boston, MA 02115. Donald H. Morgan, MA, is a graduate student in the Department of Sociology, Tulane University, New Orleans, LA 70118. David F. Gordon, Ph.D., is Associate Professor, Department of Sociology, State University of New York, Geneseo, NY 14454. 相似文献
8.
Blayne A. Standage Earl S. Schuman Stephen F. Quinn John W. Ragsdale Robert C. Sheley 《Annals of vascular surgery》1998,12(4):364-369
The purpose of this report is to describe an unusual presentation of obstructive neointimal hyperplastic lesions in loop prosthetic
dialysis grafts. The case histories and imaging studies of two patients with partial graft thrombosis are presented. The literature
of unexpected fistulae from prosthetic dialysis grafts to adjacent veins is reviewed. Signs and symptoms that would lead a
clinician to suspect the diagnosis are emphasized. There were two dialysis grafts with partial thrombosis and arterial limb
patency maintained by iatrogenic fistula. These fistulae occurred from the erosion of pseudoaneurysms in one case and an apparent
needle stick without pseudoaneurysm in the other. Both grafts had high-grade stenotic lesions affecting the venous outflow.
In the first case this was not recognized until the graft reclotted 2 days after thrombectomy. In the most extreme cases of
graft/vein fistulae, i.e., partial graft thrombosis with arterial limb patency maintained by the fistula there is always associated
venous anastomotic or outflow stenoses which must be addressed.
Correspondence to: A. Hooson, Oregon Surgical Consultants, P.C., 1130 NW 22nd Avenue #300, Portland, OR 97210, USA. 相似文献
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Karina Vieira de Barros Gilclay Gomes de Abreu Roberta Araujo Navarro Xavier Carlos Augusto Real Martinez Marcelo Lima Ribeiro Alessandra Gambero Patrícia de Oliveira Carvalho Vera Lúcia Flor Silveira 《Nutrition (Burbank, Los Angeles County, Calif.)》2011,27(2):221-226