全文获取类型
收费全文 | 3384篇 |
免费 | 285篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 14篇 |
儿科学 | 41篇 |
妇产科学 | 32篇 |
基础医学 | 382篇 |
口腔科学 | 397篇 |
临床医学 | 551篇 |
内科学 | 610篇 |
皮肤病学 | 29篇 |
神经病学 | 162篇 |
特种医学 | 171篇 |
外科学 | 322篇 |
综合类 | 36篇 |
一般理论 | 1篇 |
预防医学 | 205篇 |
眼科学 | 76篇 |
药学 | 252篇 |
中国医学 | 2篇 |
肿瘤学 | 404篇 |
出版年
2020年 | 23篇 |
2019年 | 26篇 |
2018年 | 37篇 |
2017年 | 32篇 |
2016年 | 43篇 |
2015年 | 36篇 |
2014年 | 62篇 |
2013年 | 122篇 |
2012年 | 89篇 |
2011年 | 115篇 |
2010年 | 74篇 |
2009年 | 72篇 |
2008年 | 134篇 |
2007年 | 137篇 |
2006年 | 144篇 |
2005年 | 158篇 |
2004年 | 134篇 |
2003年 | 144篇 |
2002年 | 157篇 |
2001年 | 97篇 |
2000年 | 70篇 |
1999年 | 77篇 |
1998年 | 62篇 |
1997年 | 62篇 |
1996年 | 55篇 |
1995年 | 51篇 |
1994年 | 68篇 |
1993年 | 78篇 |
1992年 | 66篇 |
1991年 | 55篇 |
1990年 | 77篇 |
1989年 | 67篇 |
1988年 | 73篇 |
1987年 | 80篇 |
1986年 | 61篇 |
1985年 | 72篇 |
1984年 | 43篇 |
1983年 | 68篇 |
1982年 | 59篇 |
1981年 | 52篇 |
1980年 | 57篇 |
1979年 | 47篇 |
1978年 | 29篇 |
1977年 | 42篇 |
1976年 | 45篇 |
1975年 | 22篇 |
1974年 | 24篇 |
1973年 | 21篇 |
1972年 | 20篇 |
1962年 | 19篇 |
排序方式: 共有3687条查询结果,搜索用时 31 毫秒
1.
Diaper area skin microflora of normal children and children with atopic dermatitis. 总被引:1,自引:1,他引:0
下载免费PDF全文
![点击此处可从《Journal of clinical microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
In vitro studies established that neither cloth nor disposable diapers demonstrably contributed to the growth of Escherichia coli, Proteus vulgaris, Staphylococcus aureus, or Candida albicans when urine was present as a growth medium. In a clinical study of 166 children, the microbial skin flora of children with atopic dermatitis was compared with the flora of children with normal skin to determine the influence of diaper type. No biologically significant differences were detected between groups wearing disposable or cloth diapers in terms of frequency of isolation or log mean recovery of selected skin flora. Repeated isolation of S. aureus correlated with atopic dermatitis. The log mean recovery of S. aureus was higher in the atopic groups. The effects of each diaper type on skin microflora were equivalent in the normal and atopic populations. 相似文献
2.
Seymour Solomon Brian M Grosberg Deborah I Friedman Richard B Lipton 《Journal of neuro-ophthalmology》2007,27(3):243-4; author reply 244-5
3.
Seymour Etkin 《American journal of public health》1948,38(11):1551-1554
4.
Seymour Furman 《Pacing and clinical electrophysiology : PACE》1993,16(6):1355-1355
5.
6.
7.
M Powell C Koutsia-Carouzou D Voutsinas A Seymour J D Williams 《British medical journal》1987,295(6591):176-179
Between 1 January and 31 March 1986, 2434 strains of Haemophilus influenzae collected from 23 laboratories in the United Kingdom were examined. With the same criteria as previous studies in 1977 and 1981 the prevalence of resistance was: ampicillin 7.8% (6.2% beta-lactamase producers and 1.6% non-producers), tetracycline 2.7%, chloramphenicol 1.7%, trimethoprim 4.2%, and sulphamethoxazole 3.5%. of the 87 capsulated strains, 15 produced beta-lactamase, nine were resistant to ampicillin but did not produce beta-lactamase, and two strains, one of which produced beta-lactamase, were resistant to chloramphenicol and tetracycline. Since 1977 the prevalence of resistance to ampicillin, chloramphenicol, and trimethoprim has increased significantly. During 1981-6 strains resistant to ampicillin but not producing beta-lactamase and strains resistant to trimethoprim have significantly increased. 相似文献
8.
9.
John Goffin Stefan Baral Dongsheng Tu Dora Nomikos Lesley Seymour 《Clinical cancer research》2005,11(16):5928-5934
PURPOSE: Tumor responses in early-phase trials are used to determine whether new agents warrant further study. Given that spontaneous regressions are observed in melanoma and renal cell carcinoma, this study assessed whether tumor responses, particularly in these two tumor types, predict for future regulatory drug approval. EXPERIMENTAL DESIGN: The literature was reviewed to assess tumor response rates to cytotoxic agents in phase I and II trials in the following solid tumors: melanoma, renal cell carcinoma, non-small-cell lung cancer, breast cancer, ovarian cancer, colorectal cancer, and other solid tumors. Response rates were categorized and the relationship of these categories to the end point of regulatory drug approval was determined. RESULTS: Fifty-eight drugs were assessed in 100 phase I trials, and 46 of these drugs were also studied in 499 phase II trials. Higher overall response rates in both phase I trials (P = 0.03) and phase II trials (P < 0.0001) were predictive of regulatory approval. However, response in melanoma or renal cell carcinoma was not predictive for either phase I or phase II studies. CONCLUSIONS: For cytotoxic agents, although overall objective response rates reliably predict subsequent marketing approval, isolated responses in melanoma and renal cell carcinoma are not predictive. 相似文献
10.
RAMASWAMY MANIKANDAN MAGDA KUJAWA EVELYN PEARSON PATRICK H O''REILLY STEPHEN CW BROWN 《International journal of urology》2004,11(4):206-212
BACKGROUND: To evaluate the results of the tension-free vaginal tape procedure (TVT) from a patient's perspective. METHODS: Between May 1999 and January 2002, 90 patients underwent a TVT for genuine stress incontinence (GSI) and mixed incontinence. Prior to the procedure, GSI was confirmed by clinical examination and urodynamic studies. Results were then audited from patient notes and the same patients were sent questionnaires to examine results from a patient perspective. RESULTS: Overall response rate to the questionnaire was 70 (77%). The mean age of the patients was 50.4 years (range 31-83 years). Sixty-one patients had spinal anesthesia, seven had general anesthesia and two had local anesthesia. Mean hospital stay was 3.36 days (range 2-14 days) and mean period from the operation to the time of the survey and audit was 16.34 months (range 3-28; SD 6.92). Thirty-nine (56%) of the 70 patients who answered said that the operation had cured their incontinence, 16 (23%) had an improvement in their symptoms, 7 (10%) had worsening of their symptoms and 8 (11%) felt that the operation did not make any difference. The overall success rate according to the patients' perspective was 79%, whereas our audit showed an overall success rate of 86% (77% and 82%, respectively, when we compared only the 66 patients who had both notes and replies available for analysis). CONCLUSION: Although a patient's perception regarding the success of TVT tends to differ from that of a clinician, it was not found to be statistically significant (P = 0.22, McNemar test). The TVT is a very successful operation, but realistic cure rates should be offered to patients. 相似文献