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排序方式: 共有262条查询结果,搜索用时 218 毫秒
1.
Vaccine-associated paralytic poliomyelitis in a patient with MHC class II deficiency. 总被引:1,自引:0,他引:1
Nima Parvaneh Shohreh Shahmahmoudi Hamideh Tabatabai Mohsen Zahraei Taha Mousavi Abdol-Reza Esteghamati Mohammad M Gooya Setareh Mamishi Rakhshandeh Nategh Olen M Kew 《Journal of clinical virology》2007,39(2):145-148
Vaccine-associated paralytic poliomyelitis (VAPP) is a rare complication of oral polio vaccine. We describe a fatal case of VAPP in an 8-month-old boy with Major Histocompatibility Class II deficiency. The isolated poliovirus was a Sabin type 2-type 1 recombinant that showed 1.4% VP1 divergence from Sabin type 2. 相似文献
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Because the ionized species is more polar than its un-ionized counterpart, it is often assumed that the ionized species of the drug does not make a meaningful contribution to solubilization by either cosolvents or surfactants. This report extends previous studies on solubilization of the ionic species by a combination of pH control and complexation to pH control and micellization and to pH control and cosolvency. The total aqueous solubility is expressed as the addition of the concentration of all contributing species: free un-ionized drug [Du], free ionized drug [Di], un-ionized drug micelle [DuM], and ionized drug micelle [DiM] for surfactant, and free un-ionized drug [Dcu] and free ionized drug [Dci] for cosolvent. The equations indicate that under certain conditions the ionized species can be more important in determining the drug total solubility than the un-ionized species. Flavopiridol, a weak base, is used to test these newly generated equations. As expected, the micellar partition coefficient and solubilization power for ionized flavopiridol are both less than those of the un-ionized species. However, at acidic pH, the solubilities of the ionized drug in surfactant micelles [DiM] and in cosolvent-water [Dci] are both much greater than that of the un-ionized drug. This difference is because the solubilization of the ionized drug is proportional to its aqueous solubility, and its solubility [Di] can be as much as 24-fold greater than that of the free un-ionized species [Du]. 相似文献
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Williams SA Shi L Brenneman SK Johnson JC Wegner JC Fonseca V 《Journal of diabetes and its complications》2012,26(5):399-406
ObjectiveTo assess the burden of hypoglycemia among type 2 diabetes patients on antidiabetic drugs with or without use of insulin.Research Design and MethodsWe used mail surveys, administrative claims data, and enrollment information from a sample of adult commercial health plan enrollees (n = 813) with type 2 diabetes during a 12-month period. Patients' experience of hypoglycemia, its impact on patient perspectives and healthcare utilization were the outcomes evaluated.ResultsA greater percentage of patients in the antidiabetic with insulin cohort reported experiencing hypoglycemia compared with patients from sulfonylurea (SU) without insulin and non-SU without insulin cohorts (50% vs. 21% and 12%, respectively; p < 0.01 for both comparisons). While 71% of the sample reported experiencing hypoglycemic symptoms with 28% confirmed by low blood glucose levels, only 10% of the patients had evidence of hypoglycemia event in the claims database. Patients with confirmed hypoglycemia had the highest Hypoglycemia Fear Survey behavior score (8) and worry subscale score (14). Significant differences were noted between the confirmed hypoglycemia and no hypoglycemia cohorts for the 12-item Short Form Health Survey's Mental Component Score (p < 0.001) and Physical Component Score (p = 0.002), and for the EQ-5D index (p < 0.001). Diabetes-related annualized mean total healthcare costs were significantly higher for confirmed hypoglycemia vs. no hypoglycemia cohorts (p = 0.004).ConclusionsSymptomatic hypoglycemia is a more significant burden among type 2 diabetes patients treated with antidiabetic drugs than is estimated by administrative claims data and needs to be considered when choosing therapy. 相似文献
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Synthesis and anticholinesterase activity of new substituted benzo[d]oxazole‐based derivatives 下载免费PDF全文
Behjat Pouramiri Setareh Moghimi Mohammad Mahdavi Hamid Nadri Alireza Moradi Esmat Tavakolinejad‐Kermani Loghman Firoozpour Ali Asadipour Alireza Foroumadi 《Chemical biology & drug design》2017,89(5):783-789
A series of novel benzo[d]oxazole derivatives ( 6a–n ) have been synthesized and biologically evaluated as potential inhibitors of acetylcholinesterases (AChE) and butyrylcholinesterase (BChE). The chemical structures of all final compounds were confirmed by spectroscopic methods. In vitro studies showed that most of the synthesized compounds are potent acetylcholinesterase and butyrylcholinesterase inhibitors. Among them, compounds 6a and 6j strongly inhibited AChE and BChE activities with IC50 values of 1.03–1.35 and 6.6–8.1 μm , respectively. Docking studies also provided the binding modes of action and identified hydrophobic pi forces as the main interaction. 相似文献
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Road-Crossing Behavior in Complex Traffic Situations: A Comparison of Children With and Without ADHD
Tabibi Zahra Schwebel David C. Zolfaghari Hamid 《Child psychiatry and human development》2022,53(6):1186-1193
Child Psychiatry & Human Development - All children are vulnerable to pedestrian injuries, but previous research suggests children diagnosed with ADHD may have elevated risk. Child pedestrian... 相似文献
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Soroor Golnoosh Mokhtari Setareh Pouretemad Hamidreza 《Journal of autism and developmental disorders》2022,52(3):1019-1029
Journal of Autism and Developmental Disorders - We investigated (1) if the perceptual integration performance is different in children with ASD in comparison with their typically developed (TD)... 相似文献
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Movahedi M Entezari N Pourpak Z Mamishi S Chavoshzadeh Z Gharagozlou M Mir-Saeeid-Ghazi B Fazlollahi MR Zandieh F Bemanian MH Farhoudi A Aghamohammadi A 《Journal of clinical immunology》2007,27(3):302-307
Leukocyte adhesion deficiency type I (LAD I) is a rare, inherited, autosomal recessive, immunodeficiency disease caused by
the combined loss of expression on the surface of leukocytes of the leukocyte integrins. We describe the clinical and laboratory
findings for 15 patients with LAD I.
The range of patients’ ages was from 10 month to 14 years (median 4 years) and 93.3% of their parents had consanguineous marriages.
The most commonly occurred manifestations were: recurrent infections (93.3%), poor wound healing (86%), oral ulcers (86%),
and skin abscesses (80%). The most specific laboratory findings were defect in CD18 in all of 15 patients.
The most common symptoms in these patients are poor wound healing and oral ulcer, so, the clinical physicians should pay special
attention to these symptoms. Furthermore, because of considerable rate of consanguineous marriages in parents of LAD patients,
we suggested more genetic studies on this disease and genetic consultation for these families.
An erratum to this article can be found at 相似文献