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1.
HELANDER ANDERS; CARLSSON ANNETTE VOLTAIRE; BORG STEFAN 《Alcohol and alcoholism (Oxford, Oxfordshire)》1996,31(1):101-107
The utility of carbohydrate-deficient transferrin (CDT) andgamma-glutamyl transferase (GGT) as biochemical markers of excessivealcohol consumption was studied in alcohol-dependent subjects.Serum samples were collected once weekly from 10 male out-patientsundergoing a 6-month alcohol treatment programme. Frequencyof relapse into drinking (defined as any intake of alcoholicbeverage) was assessed by self-reports during patient interviewsthree times per week and by daily determination of the 5-hydroxytryptophollevel in urine. A marked decrease in mean CDT and GGT valueswas observed during the initial month. Only one patient remainedtotally abstinent throughout the observation period, while fourhad sporadic relapses (25 days with alcohol consumption).Both CDT and GGT remained below the respective reference limitsin those patients. The other five patients drank more frequently(range 2257 days) and increased their mean levels ofCDT and GGT after the initial decrease. As determined from thevalues at admission and during the course of the study, CDTappeared to be the most sensitive marker in six out of the 10patients. In one patient, both markers were affected in a parallelway, whereas two of those with frequent relapses responded toalcohol consumption with a marked increase in GGT, but withno or only a slight increase in CDT. One patient did not showany abnormal CDT or GGT values. In 54 female and 60 male serumsamples collected at random from patients during admission atan alcohol detoxification unit, 35% and 58% of the CDT valuesexceeded the reference limits for females and males, respectively.For GGT, 59% of the female and 67% of the male values were abovecut-off. Carbohydrate-deficient transferrin and GGT were notsignificantly correlated. Taken together, the present resultsindicate that measurement of both CDT and GGT will increasethe possibility of identifying excessive alcohol consumption.By following changes in CDT and GGT values during a period ofalcohol withdrawal, the most sensitive individual marker canbe determined. This in turn allows for improved detection ofrelapse into heavy drinking dunng long-term monitoring of out-patients. 相似文献
2.
Using both slack tests and force clamp experiments, the velocity of unloaded shortening (Vu; Vu(st), slack test; Vu(fc), force
clamp) was determined for maximally Ca2+-activated myofibrillar bundles. These were obtained by mechanically splitting single
muscle fibres of rat, rabbit, crab and lobster skeletal muscles. A comparison was made between the Vu of thick (mammalian:
45-70 mum mean diameter; crustacean: 90-175 mum) and thin (mammalian: 25-40 mum; crustacean: 35-85mum) preparations of the
same muscle fibre. The bundle diameter had opposite effects on Vu in mammalian and crustacean muscle fibres. The Vu of thin
mammalian bundles was about 0.6times that of the thick ones, whereas in crustacean preparations this ratio was about 1.5.
The kinetics of stretch-induced delayed force increase of maximally Ca2+-activated fibres (stretch activation) appeared not
to differ between the thick and thin bundles from any animal preparation. Control experiments showed that the observed diameter
effects on Vu are not due to differences in the chemical environment of the myofilaments. One possible explanation is that
the intrinsic physical factors of the myofibrils modify Vu differently during progressive shortening in mammalian and crustacean
preparations.
This revised version was published online in August 2006 with corrections to the Cover Date. 相似文献
3.
Impact of the Right Ventricular Lead Position on Clinical End Points in CRT Recipients—A Subanalysis of the Multicenter Randomized SPICE Trial 下载免费PDF全文
STEFAN ASBACH M.D. CARSTEN LENNERZ M.D. VERENA SEMMLER M.D. CHRISTIAN GREBMER M.D. ULRICH SOLZBACH M.D. AXEL KLOPPE M.D. NORBERT KLEIN M.D. ISTVAN SZENDEY M.D. GEORGE ANDRIKOPOULOS M.D. STYLIANOS TZEIS M.D. CHRISTOPH BODE M.D. CHRISTOF KOLB M.D. †; ON BEHALF OF THE SPICE STUDY INVESTIGATORS 《Pacing and clinical electrophysiology : PACE》2016,39(3):261-267
4.
5.
SUSAN KEATING THEO
DE WITTE STEFAN SUCIU ROEL WILLEMZE MARCEL HAYAT BORIS LABAR LUIGI RESEGOTTI PIERLUIGI ROSSI FERRINI FRANCESCO CARONIA MURIELLE DARDENNE GABRIEL SOLBU MARIA CONCETTA PETTI MARIA LUCE VEGNA FRANCO MANDELLI ROBERT A. ZITTOUN 《British journal of haematology》1998,102(5):1344-1353
To determine whether patients with a HLA-identical sibling donor have a better outcome than patients without a donor, an analysis on the basis of intention-to-treat principles was performed within the framework of the EORTC-GIMEMA randomized phase III AML 8A trial. Patients in complete remission (CR) received one intensive consolidation course. Patients with a histocompatible sibling donor were then allocated allogeneic bone marrow transplantation (alloBMT), the patients without a donor were randomized between autologous BMT (ABMT) and a second intensive consolidation (IC2). 831 patients <46 years old and alive >8 weeks from diagnosis were included. HLA typing was performed in 672 patients. AlloBMT was performed during CR1 in 180 (61%) out of 295 patients with a donor. Another 38 patients were allografted: five in resistant disease, 14 during relapse and 19 in CR2. ABMT was performed in 130 (34%) out of 377 patients without a donor in CR1, in six (2%) patients during relapse and in 38 (10%) patients during CR2. The disease-free survival (DFS) from CR for patients with a donor was significantly longer than for patients without a donor (46% v 33% at 6 years; P = 0.01, RR 0.78, 95% confidence interval 0.63–0.96). The overall survival from diagnosis for patients with a donor was longer, but not statistically significant, than for patients without a donor (48% v 40% at 6 years; logrank P = 0.24). When patients were stratified according to prognostic risk groups, the same trend in favour of patients with a donor was seen for survival duration and the DFS remained significantly longer for this group of patients. 相似文献
6.
Changes in Plasma Epinephrine Concentration and in Heart Rate During Head-Up Tilt Testing in Patients with Neurocardiogenic Syncope: 总被引:3,自引:0,他引:3
THOMAS KLINGENHEBEN M.D. DIETRICH KALUSCHE M.D. YI-GANG LI M.D. MATTHIAS SCHÖPPERL M.D. STEFAN H. HOHNLOSER M.D. 《Journal of cardiovascular electrophysiology》1996,7(9):802-808
Sympathetic Activation in Neurocardiogenic Syncope. Introduction : Tilt table testing is widely used in the management of patients with neurocardiogenic syncope. However, the exact pathophysiologic mechanism of this disorder is still under debate. Likewise, therapy of these patients continues to represent a challenge in many cases. Therefore, the present study aimed to gain further insight into the pathophysiology of this syndrome and to examine easily accessible clinical parameters that can improve therapy selection.
Methods and Results : In 16 patients with neurocardiogenic syncope, changes in endogenous catecholamine concentrations were determined during repeated tilt table testing before and during treatment with metoprolol. Tachycardia preceded syncope in 8 of 10 responders compared to only 1 of 6 nonresponders (P < 0.05). In responders, the relative increase in epinephrine levels averaged 197%± 51% during drug-free tilting and 75%± 33% during repeated testing while on β-blocker therapy (P < 0.05). In nonresponders, there was a smaller relative increase in epinephrine averaging 137%± 35% at baseline tilt. During repeated tilt testing, a similar increase was observed in these patients with recurrent syncope (156%± 104%; P = NS compared to baseline).
Conclusion : In patients with neurocardiogenic syncope who show both an increase in epinephrine concentration during tilt test and sinus tachycardia prior to the onset of symptoms, β-blocker treatment is very effective. These findings confirm the major role of sympathetic activation as a trigger of syncope. Particularly, heart rate changes at the onset of syncope may allow early identification of patients responding to antiadrenergic therapy. 相似文献
Methods and Results : In 16 patients with neurocardiogenic syncope, changes in endogenous catecholamine concentrations were determined during repeated tilt table testing before and during treatment with metoprolol. Tachycardia preceded syncope in 8 of 10 responders compared to only 1 of 6 nonresponders (P < 0.05). In responders, the relative increase in epinephrine levels averaged 197%± 51% during drug-free tilting and 75%± 33% during repeated testing while on β-blocker therapy (P < 0.05). In nonresponders, there was a smaller relative increase in epinephrine averaging 137%± 35% at baseline tilt. During repeated tilt testing, a similar increase was observed in these patients with recurrent syncope (156%± 104%; P = NS compared to baseline).
Conclusion : In patients with neurocardiogenic syncope who show both an increase in epinephrine concentration during tilt test and sinus tachycardia prior to the onset of symptoms, β-blocker treatment is very effective. These findings confirm the major role of sympathetic activation as a trigger of syncope. Particularly, heart rate changes at the onset of syncope may allow early identification of patients responding to antiadrenergic therapy. 相似文献
7.
DICK STOCKELBERG MING HOD STEFAN JACOBSSON JACK KUTTI HANS WADENVIK 《British journal of haematology》1995,90(1):175-179
To address the assumption of clonally restricted antibodies in immune thrombocytopenias we studied sera from 19 patients with chronic ITP known to possess antibodies reactive with glycoprotein (GP) Ib/IX and/or GPIIb/IIIa. These sera were re-analysed using the standard monoclonal antibody immobilization of platelet antigens (MAIPA) assay and 16 patients exhibited IgG antibodies reactive with GPIIb/IIIa; seven patients showed also a reactivity with GPIb/IX. Employing a light-chain-specific MAIPA assay, 75% (12/16) of these sera displayed GPHb/ Ilia-specific antibodies that were light chain restricted; only 13% (2/16) of the GPIIb/IHa reactive sera showed a mixed kappa and lambda phenotype. A light-chain-restricted phenotype was also seen for the GPIb/IX reactive antibodies. To further substantiate these findings, the MAIPA assay was modified in order to avoid interference from human anti-mouse antibodies. A high frequency of light-chain restricted platelet antibodies was also found using the modified MAIPA technique. These results support the hypothesis of a clonal B-cell expansion in immune thrombocytopenias, producing antibodies with a restricted idiotype repertoire and reacting with a limited number of epitopes. 相似文献
8.
Zusammenfassung Das postmortale Capillarbild des ZNS wurde bei mit Insulin behandelten Ratten und Kaninchen mit Hilfe der Benzidinmethode von Slonimski und Cunge näher untersucht. Sofern die Tiere nicht spontan starben, wurden sie zu bestimmten Zeitpunkten nach der Insulininjektion durch Leuchtgasinhalation oder Säureinjektion oder Dekapitation getötet. Diese Eingriffe führen bei unbehandelten Tieren zu einer gleichmäßigen Gefäßerweiterung in allen Abschnitten des ZNS.Sowohl bei spontan gestorbenen als auch bei in der angegebenen Weise getöteten Insulintieren konnten Störungen in der Vascularisierung des ZNS festgestellt werden. Dabei wurde die ganze Skala der Möglichkeiten von extremster Verengung über teilweisen Schwund bis zum vollständigen Ausfall der Capillaren beobachtet.Am empfindlichsten reagiert dabei die Gro\hirnrinde, während in den übrigen Abschnitten des ZNS, also etwa im Thalamus oder Kleinhirn erst sehr viel später Störungen in der Gefäßversorgung aufzutreten pflegen. Größe der Insulindosis und Dauer der Insulinwirkung spielen dabei eine Rolle.Es wird diskutiert, inwieweit aus diesen postmortal erhobenen Befunden Rückschlüsse auf die vitale Durchblutung gezogen werden können und welche Folgerungen sich eventuell daraus für die Beurteilung von Durchblutungsmessungen und Bestimmungen von arteriovenösen Differenzen, die am gesamten ZNS erhoben wurden, ergeben könnten.Mit 9 Textabbildungen. 相似文献
9.
MATS ÅKERLUND ARNAR HAUKSSON STEFAN LUNDIN PER MELIN JERZY TROJNAR 《BJOG : an international journal of obstetrics and gynaecology》1986,93(1):22-27
Summary. Three analogues of posterior pituitary hormones, 1 - deamino - 2 - D - Tyr(OEt) - 4 - Val - 8 - Om - vasotocin(dE - VVT), l-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-vasotocin(dE-TVT) and 1-deamino-2-D-Tyr(OEt)-oxytocin(dE-OXY) were compared for their inhibitory effects on vasopressin (VP)-induced uterine activity in healthy women. At menstruation, during recording of intrauterine pressure (18 recording sessions in 11 women), intravenous infusion of lysine vasopressin (LVP, 1 ng/min/kg/body weight) induced an increase of the uterine activity and dysmenorrhoea-like symptoms. Intravenous injections of all analogues (10 μg/kg body weight) caused relief of symptoms and inhibition of uterine activity, dE-TVT was the most effective and dE-OXY was least active. With dE-TVT almost complete inhibition of contractions was seen during the first 10 min after injection. The duration of effect was also greatest with that analogue (40–50 min). Only dE-OXY had an agonist effect on spontaneous uterine activity. Pharmacokinetic studies of intravenous dE-TVT (10 ng/kg body weight) showed that the plasma half-life was approximately 16 min and the clearance 30 1/h. The bioavailability of 100 ng/kg given intra-nasally was about 5·5%. Further studies are recommended. 相似文献
10.
We report a five-month-old infant with an impaired left ventricular ejection fraction as a result of Bland-White-Garland-syndrome (BWGS). Total intravenous anaesthesia with fentanyl and midazolam was used as the anaesthetic technique. After aortic reimplantation of the left coronary artery weaning from cardiopulmonary bypass (CPB) was prolonged and was only successfully managed with high dose noradrenaline, dopamine and dobutamine. Persistent myocardial dysfunction led to prolonged intensive care treatment. Seven months after surgery, left ventricular function and clinical condition have improved significantly. 相似文献