全文获取类型
收费全文 | 76篇 |
免费 | 4篇 |
专业分类
耳鼻咽喉 | 2篇 |
基础医学 | 3篇 |
临床医学 | 4篇 |
内科学 | 5篇 |
皮肤病学 | 4篇 |
神经病学 | 2篇 |
特种医学 | 1篇 |
外科学 | 16篇 |
预防医学 | 1篇 |
药学 | 4篇 |
肿瘤学 | 38篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 4篇 |
2020年 | 1篇 |
2019年 | 4篇 |
2018年 | 3篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 6篇 |
2012年 | 9篇 |
2011年 | 1篇 |
2010年 | 2篇 |
2008年 | 1篇 |
2007年 | 4篇 |
2006年 | 7篇 |
2005年 | 3篇 |
2004年 | 3篇 |
2003年 | 1篇 |
2002年 | 4篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1979年 | 1篇 |
1968年 | 1篇 |
1967年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有80条查询结果,搜索用时 15 毫秒
1.
Nobuhiro Kawatsuki Ken Takatani Tohei Yamamoto Osamu Sangen 《Macromolecular chemistry and physics.》1997,198(9):2853-2866
Photoreactive (meth)acrylate monomers having mesogenic groups based on 4-hexyloxy-4′-(3-methyl-2-butenyloxy)biphenyl and 4-hexyloxy-4′-(2-butenyloxy)biphenyl were synthesized. Methacrylate monomers ( 3c, d ) and acrylate monomer having 3-methyl-2-butenyloxy group ( 3b ) were polymerized by free radical mechanism; the acrylate monomer having 2-butenyloxy group ( 3a ) caused gelation during the polymerization. To obtain photoreactivity, 4-benzoylphenyl (meth)acrylates were radically copolymerized with monomers 3b and 3d . Thermal behavior of (co)polymers was determined by differential scanning calorimetry, polarized optical microscopy and temperature-controlled X-ray analysis. (Co)polymers showed liquid-crystalline behaviour with nematic and smectic phases. UV-irradiation was used to photochemically crosslink copolymer films, and the resultant films were insoluble in organic solvents. The uniaxially oriented copolymer thin film was photo-crosslinked and showed thermally stable orientation. 相似文献
2.
<药品管理法>第三十二条规定:药品必须符合国家药品标准.中华人民共和国药典、国家药品监督管理局颁发的药品标准、以及仍在使用的卫生部颁布的药品标准都是国家药品标准.国家药品监督管理局规定,局颁标准从2002年12月1日起生效,同品种地方标准、包装、标签和说明书同时停止使用.但是我们在具体工作时,遇到了同品种药品不仅出现在地方标准,而且还在三个国家标准中出现,此外还发现局颁标准的编印质量不高.这就对标准的可操作性、严肃性构成了威胁,现分述如下,以期引起有关部门的注意. 相似文献
3.
4.
5.
Daisuke Usuda Toshihide Izumida Nao Terada Ryusho Sangen Toshihiro Higashikawa Sayumi Sekiguchi Risa Tanaka Makoto Suzuki Yuta Hotchi Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Suguru Asako Yoshie Takagi Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita Yuji Kasamaki 《World Journal of Clinical Cases》2021,9(23):6886-6899
6.
7.
Ingrid G.M. Poodt Robert-Jan Schipper Guusje Vugts Karlijn Woensdregt Maurice van der Sangen Adri C. Voogd Grard A.P. Nieuwenhuijzen 《European journal of surgical oncology》2018,44(11):1714-1719
Background
The proportion of elderly women diagnosed with breast cancer is rising. Standard treatment, including axillary staging, is often not given to these patients. This study aimed to investigate reasons to omit any surgical axillary staging or to refrain from completion axillary lymph node dissection (cALND) after positive-sentinel lymph node biopsy (SLNB); so-called “incomplete staging”. Furthermore, the impact of incomplete staging on regional control and survival in patients aged 75 or older was evaluated.Methods
A retrospective cohort study was conducted including all primary breast cancer patients aged 75 or older, diagnosed between 2001 and 2008, and documented by the Netherlands Cancer Registry (NCR). Patients with incomplete staging were compared to patients with complete axillary staging. Survival analyses were used to determine the risk of local, regional and distant recurrence and overall survival.Results
In total, 1467 of 2116 (69%) patients were considered eligible, of whom 258 (17.2%) had incomplete axillary staging. For 93 patients, diagnosed in 6 of the 10 hospitals in the NCR-area, examination of clinical records revealed that age, comorbidities and patient preferences were the main reason for omitting complete axillary staging. The 10-year axillary recurrence rate in these 93 patients was 5.2% (95% CI, 0.03–10.1). Of the 77 patients who had died, 64 (83%) died of non-breast-cancer-related causes. No significant difference in overall survival was observed between patients with or without complete axillary staging.Conclusion
This study demonstrates that the omission of complete axillary staging is common in selected elderly breast cancer patients with ≥2 comorbidities, with no apparent impact on regional control and 10-year overall survival. 相似文献8.
Videomicroscopic and histopathological investigation of intense pulsed light therapy for solar lentigines 总被引:6,自引:0,他引:6
Kawada A Asai M Kameyama H Sangen Y Aragane Y Tezuka T Iwakiri K 《Journal of dermatological science》2002,28(2):91-96
A specialized subpopulation of unmyelinated chemonociceptors and dedicated spinal neurons which are responsible for the itch sensation have been identified recently. Under physiological conditions, painful stimuli such as activation of conventional mechano-heat-sensitive ('polymodal') nociceptors (scratching) inhibit the itch sensation via central mechanisms. Conversely, centrally acting pain-inhibiting opioids enhance itch by disinhibition. These mechanisms might well explain the itch in diseases characterized by histamine release like urticaria, and might provide evidence for the role of endogenous opioids as central itch promotors in cholestasis or nephropathy. After the discovery of itch-specific neurons has dramatically improved our understanding of itch mechanisms under experimental conditions, the present task is to correlate these new findings to the clinical situation of itch patients. 相似文献
9.
M.S. Koedijk M.J.C. van der Sangen P.M.P. Poortmans P. van Mierlo-Jansen W.T. van den Broek B.H.M. Storck A.C. Voogd 《European journal of surgical oncology》2013
Background
The purpose of the study was to determine the effectiveness of routine follow-up to detect contralateral breast cancer (CBC) in young women.Methods
We used the data of the population-based Eindhoven Cancer Registry, which covers the southern part of the Netherlands. Between 1988 and 2005, 1451 women aged ≤40 years were treated for early-stage breast cancer with breast-conserving treatment or mastectomy.Results
Of the 94 patients who developed CBC 17 had an in situ carcinoma. Fifty-seven CBCs (61%) were diagnosed more than 5 years after the primary tumour. Forty-two CBCs (45%) were detected during routine follow-up visits, while 52 (55%) presented between two visits. Of the CBC diagnosed between two visits, only 27 (60%) were visible on mammography. Of the invasive CBCs more than 25% was larger than 2 cm in diameter and in 34% positive axillary lymph nodes were found.Conclusions
These figures indicate that routine follow-up does not guarantee early detection of CBC in young women with breast cancer. 相似文献10.
Determinants of axillary recurrence after axillary lymph node dissection for invasive breast cancer.
A C Voogd R de Boer M J van der Sangen R M Roumen H J Rutten J W Coebergh 《European journal of surgical oncology》2001,27(3):250-255
AIM: This study was undertaken to gain insight into the risk factors for axillary recurrence among patients with invasive breast cancer who underwent breast-conserving treatment or mastectomy and axillary lymph node dissection. METHODS: In a matched case-control design, 59 patients with axillary recurrence and 295 randomly selected control patients without axillary recurrence were compared. Matching factors included age, year of incidence of the primary tumour and postsurgical axillary nodal status. RESULTS: For patients with negative axillary lymph nodes, those with a tumour in the medial part of the breast had a 73% (95% CI: 4-92%) lower risk of axillary recurrence compared to those with a tumour in the lateral part of the breast. For the patients with positive axillary lymph nodes the risk of axillary recurrence was 65% (95% CI: 16-86%) lower for those who had received axillary irradiation compared to those without axillary irradiation. Within the age group <50 years, the risk or axillary recurrence was 82% lower (95% CI: 45-94%) for patients with more than six lymph nodes found in the axillary specimen compared to those with six or less than six lymph nodes. CONCLUSIONS: Although based on a small number of patients, this study indicates that axillary irradiation is effective in reducing the risk of axillary recurrence for patients with positive lymph nodes. This favourable effect only applies to the subgroup with extranodal extension or nodal involvement in the apex of the axilla, as these were the only patients receiving axillary radiation during the study period. Copyright Harcourt Publishers Limited. 相似文献