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排序方式: 共有315条查询结果,搜索用时 15 毫秒
1.
Splenic trauma and overwhelming postsplenectomy infection 总被引:5,自引:0,他引:5
2.
Resource implications of hospitalization for osteoporosis-related vertebral fracture are sparsely documented. This study
utilized data abstracted from a national sample of hospitalized patients to identify characteristics of patients who are hospitalized
with vertebral fracture and their patterns of resource utilization. These were compared with patterns observed for hip fracture
hospitalizations. Data from the Nationwide Inpatient Sample (NIS) for 1997 were used to identify men and women age 45 years
and above who had a primary diagnosis of vertebral fracture. After patients whose fractures might have been due to metastatic
cancer or severe trauma were excluded, 68 901 individuals hospitalized for vertebral fracture were identified. Seventy-seven
percent of these were women, most were white, 75 years and older, and had multiple comorbid diagnoses. Total charges averaged
US$8000–10 000 per hospitalization and were higher in men. Mean length of stay was just under 6 days and more than 50% of
discharged patients required some form of continuing care. Hospitalizations for vertebral fracture occurred at only one-fourth
the rate of those for hip fracture, and created only half the hospital charges per admission. Vertebral fracture accounted
for over 400 000 total hospital days and generated charges in excess of US$500 million. This resource impact is considerably
higher than has been described in prior studies.
Received: 25 June 2002 / Accepted: 13 August 2002
Acknowledgement This research was supported by Procter & Gamble Pharmaceuticals and Aventis. 相似文献
3.
The nature of the contact sites formed during the adhesion of osteoblasts to orthopedic implant materials was investigated by fluorescence microscopy. More specifically, the cytoskeletal organization of and the focal contact formation by neonatal rat calvarial osteoblasts attaching to and spreading on 316L stainless steel, Ti-6Al-4V, Co-Cr-Mo, Synamel (hydroxyapatite), alumina, and borosilicate glass were examined. Focal contacts are regions where the plasma membrane approaches the substrate to within 10-15 nm and where bundles of cytoskeletal microfilaments terminate. Fluorescent-labeling of F-actin-containing microfilaments demonstrated a typical sequence of events as rounded, suspended osteoblasts spread onto the substrates. Immunofluorescent-labeling of the protein vinculin, which is found at the cytoplasmic face of focal contacts, initially showed the formation of streak-like focal patches. On the biomaterials, the vinculin staining subsequently extended up and along, but ventral to, the microfilament bundles. The fibrillar patterns observed at later times may evidence the formation of extracellular matrix contacts. 相似文献
4.
Kathryn Leary Harry H. Yim Lu Bing Zhou Rose E. Sekulovich Rozanne M. Sandri-Goldin 《Virus genes》1989,3(1):57-68
To determine the role of the HSV-1 genome structure and environment on the regulation of gene expression, we constructed recombinant viruses containing a heterologous gene inserted into either the immediate early ICP0 or late glycoprotein C (gC) genes of HSV-1. The heterologous gene consisted of the SV40 early promoter (without enhancer sequences) linked to the coding sequences for the bacterial chloramphenicol acetyl transferase (CAT). The expression of CAT was examined in Vero cells infected with either virus (named ICP0-CAT and Sph 6). For both recombinants, expression of CAT was not dependent upon prior viral protein synthesis. The kinetics of expression of CAT-specific mRNA resembled that of the HSV-1 genes into which CAT was inserted. Primer extension analysis revealed that the SV40 promoter is recognized and used when placed in cis in two different HSV-1 genome locations, and Northern hybridization experiments confirmed that the heterologous gene was expressed in the absence of prior viral protein synthesis. Therefore, this gene was not regulated as strictly as an HSV-1 gene, but was influenced by the environment into which it was placed, presumably by factors that are present when the normal viral gene is on. 相似文献
5.
6.
Karen M Emmons Rita M Butterfield Elaine Puleo Elyse R Park Ann Mertens Ellen R Gritz Maureen Lahti Fredrick P Li 《Journal of clinical oncology》2003,21(2):189-196
PURPOSE: This article describes baseline data collection and the intervention design of Partnership for Health, a smoking cessation intervention for smokers in the Childhood Cancer Survivors Study. The purpose of this article is to evaluate demographic, psychosocial, and cancer-related factors that are associated with smoking behavior and mediators of smoking cessation. PATIENTS AND METHODS: This study includes 796 smokers from the Childhood Cancer Survivors Study database who were diagnosed with cancer before the age of 21, had survived at least 5 years, and were at least 18 years of age at the time of the baseline survey. Correlates of smoking behaviors included smoking rate, number of recent quit attempts, and nicotine dependence; two key mediators of smoking cessation, readiness to quit smoking and self-efficacy, were also assessed. RESULTS: Participants smoked, on average, 14 cigarettes/day; 53.2% were nicotine dependent, and 58% had made at least one quit attempt in the past year. Smoking behaviors were primarily associated with demographic variables; mediators of cessation were primarily associated with age at cancer diagnosis and perceived vulnerability to smoking-related illnesses. Severity of psychologic symptoms was associated with increased smoking rate, high nicotine dependence, and low self-efficacy. Support for quitting was related to smoking rate, number of quit attempts, readiness to quit smoking, and self-efficacy. CONCLUSION: These findings indicate that many cancer survivors who smoke are receptive to smoking cessation interventions. Factors related to mediators of smoking cessation might be particularly good targets for intervention. 相似文献
7.
Matthew B. Doelp Jack A. Puleo Paul Cowan Michelle Arford-Granholm 《The American journal of emergency medicine》2018,36(8):1372-1379
Introduction
Beaches are a popular destination for recreation activities. Surf zone injuries (SZI) can occur resulting from a variety of in-water activities. Little is known regarding the sustained injury types, or demographics of injured persons and activities leading to injuries.Methods
This study examines the distribution of SZI types, activities and populations occurring on Delaware Beaches as recorded by a local level III trauma center (Department of Emergency Medicine at Beebe Healthcare in Lewes, Delaware).Results
There were 2021 injuries over the eight study years (2010–2017). The relative demographics of the injured population are similar despite fluctuating injury totals (mean [SD], 253.1 [104.4]). Non-locals (n = 1757) were 6.7 times more likely to be injured as their local (n = 264) counterparts (RR, 2.62; 95% CI, 2.08–3.31). Males (n = 1258) were 1.7 times more likely to be injured than their female (n = 763) counterparts (RR, 1.29; 95% CI, 1.21–1.37). Serious injuries, defined as patients requiring admission to a trauma service, represented 9.1% (n = 184) of injuries. Fatal SZI (n = 6) were categorized as serious injuries. Wading (50.1%) was found to be the dominant activity associated with injury followed by body surfing (18.4%), and body boarding (13.3%).Conclusion
To the authors' knowledge, this study is one of the first to investigate long-term trends in SZI data, injury activity, and demographics. Better understanding of the characteristics of injuries will allow for improved awareness techniques, targeted at populations with higher injury rates. 相似文献8.
Brian A. Reikie Shalena Naidoo Candice E. Ruck Amy L. Slogrove Corena de Beer Heleen la Grange Rozanne C. M. Adams Kevin Ho Kinga Smolen David P. Speert Mark F. Cotton Wolfgang Preiser Monika Esser Tobias R. Kollmann 《Clinical and Vaccine Immunology : CVI》2013,20(1):33-38
HIV-exposed but uninfected (HEU) infants born to HIV-infected mothers from areas in the world with a high burden of infectious disease suffer higher infectious morbidity and mortality than their HIV unexposed uninfected (HUU) peers. Vaccination provides protection from infection. The possibility exists that altered response to vaccination contributes to the higher rate of infection in HEU than in HUU infants. While short-term, cross-sectional studies support this notion, it is unclear whether or not HEU infants develop long-term protective immune responses following the WHO extended program on immunization (EPI). Vaccine-specific antibody responses were compared between HEU and HUU infants from 2 weeks until 2 years of age in a longitudinal South African cohort. Total IgG and antibodies specific for Bordetella pertussis, Haemophilus influenzae type b (Hib), tetanus toxoid, hepatitis B virus (HepB), and measles virus were measured at multiple time points throughout the first 2 years of life. Prevaccine antibodies (maternal antibodies passively acquired) specific for tetanus were lower in HEU than in HUU infants, while prevaccine antibodies to HepB were higher in HEU than in HUU infants. Both groups responded similarly to tetanus, Hib, and HepB vaccination. HEU demonstrated stronger pertussis vaccine responses, developing protective titers 1 year earlier than HUU patients, and maintained higher anti-tetanus titers at 24 months of age. Vaccine-induced antibodies to measles virus were similar in both groups at all time points. Our results suggest that the current EPI vaccination program as practiced in South Africa leads to the development of vaccine-specific antibody responses that are equivalent in HEU and HUU infants. However, our data also suggest that a large fraction of both HEU and HUU South African infants have antibody titers for several infectious threats that remain below the level of protection for much of their first 2 years of life. 相似文献
9.
Marcello Giuseppe Spampinato Marianna Arvanitakis Francesco Puleo Lucio Mandala Giuseppe Quarta Donatella Traisci Antonella Plaia Nicola Di Bartolomeo Giànandrea Baldazzi Umberto Cillo 《Surgical endoscopy》2013,27(6):1881-1886
Background
Standard oncologic liver resections performed on elderly patients (≥70 years old) have been shown to be safe and effective. The aim of this study was to analyze operative and oncologic short-term outcomes of totally laparoscopic liver resections (TLLR) performed on elderly patients for malignancies.Methods
We performed a retrospective statistical analysis of prospectively recorded data of TLLR performed from October 2008 to February 2012 by a single hepato-pancreato-biliary (HPB) surgeon. Patients were divided into two groups according to age (<70 vs. ≥70 years old) and perioperative outcomes were compared.Result
A total of 60 TLLR for malignancies were identified of which 25 patients (42 %) were aged ≥70 years (Group A) and 35 (58 %) were aged <70 years (Group B). There was no difference in operative time (170 vs. 180 min, p = 0.267), median blood loss (200 vs. 250 ml, p = 0.183), number and time of Pringle maneuver (p = 0.563 and p = 0.180), blood transfusion rate (4 vs. 17 %, p = 0.222), conversion rate (4 vs. 9 %, p = 0.443), morbidity rate (12 vs. 20 %, p = 0.797), and perioperative mortality rate (0 vs. 3 %, p = 0.688). An R0 resection was achieved in 92 (Group A) versus 83 % (Group B) (p = 0.265). At a median follow-up of 18 months, 12 % of patients in Group A experienced a disease recurrence with a related mortality rate similar to that of Group B (8 vs. 12 %, p = 0.375).Conclusion
This retrospective comparative study shows that TLLR performed on elderly for liver neoplasm are feasible and safe and lead to short-term outcomes similar to those of younger patients. 相似文献10.
Vernon K. Sondak MD Dennis W. King PhD Jonathan S. Zager MD Schlomo Schneebaum MD Julian Kim MD Stanley P. L. Leong MD Mark B. Faries MD Bruce J. Averbook MD Steve R. Martinez MD Christopher A. Puleo PA-C Jane L. Messina MD Lori Christman PhD Anne M. Wallace MD 《Annals of surgical oncology》2013,20(2):680-688