全文获取类型
收费全文 | 214篇 |
免费 | 8篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 5篇 |
妇产科学 | 9篇 |
基础医学 | 9篇 |
口腔科学 | 17篇 |
临床医学 | 18篇 |
内科学 | 31篇 |
皮肤病学 | 1篇 |
神经病学 | 7篇 |
特种医学 | 1篇 |
外科学 | 80篇 |
综合类 | 1篇 |
预防医学 | 8篇 |
眼科学 | 29篇 |
药学 | 2篇 |
肿瘤学 | 3篇 |
出版年
2023年 | 1篇 |
2022年 | 3篇 |
2020年 | 3篇 |
2019年 | 4篇 |
2018年 | 9篇 |
2017年 | 4篇 |
2016年 | 8篇 |
2015年 | 7篇 |
2014年 | 8篇 |
2013年 | 17篇 |
2012年 | 14篇 |
2011年 | 12篇 |
2010年 | 8篇 |
2009年 | 11篇 |
2008年 | 13篇 |
2007年 | 23篇 |
2006年 | 13篇 |
2005年 | 21篇 |
2004年 | 15篇 |
2003年 | 10篇 |
2002年 | 5篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1993年 | 2篇 |
排序方式: 共有222条查询结果,搜索用时 421 毫秒
1.
Selcen Yuksel Selim Ayhan Vugar Nabiyev Montse Domingo-Sabat Alba Vila-Casademunt Ibrahim Obeid Francisco Sanchez Perez-Grueso Emre Acaroglu 《The spine journal》2019,19(1):71-78
BACKGROUND CONTEXT
Health-related quality of life (HRQOL) parameters have been shown to be reliable and valid in patients with adult spinal deformity (ASD). Minimum clinically important difference (MCID) has become increasingly important to clinicians in evaluating patients with a threshold of improvement that is clinically relevant.PURPOSE
To calculate MCID and minimum detectable change (MDC) values of total scores of the Core Outcome Measures Index (COMI), Oswestry Disability Index (ODI), Physical Component Summary (PCS), Mental Component Summary (MCS) of the Short Form 36 (SF-36), and Scoliosis Research Society 22R (SRS-22R) in surgically and nonsurgically treated ASD patients who have completed an anchor question at pretreatment and 1-year follow-up.STUDY DESIGN/SETTING
Prospective cohort.PATIENT SAMPLE
Surgical and nonsurgical patients from a multicenter ASD database.OUTCOME MEASURES
Self-reported HRQOL measures (COMI, ODI, SF-36, SRS-22R, and anchor question).METHODS
A total of 185 surgical and 86 nonsurgical patients from a multicenter ASD database who completed pretreatment and 1-year follow-up HRQOL scales and the anchor question at the first year follow-up were included. The anchor question was used to determine MCID for each HRQOL measure. MCIDs were calculated by an anchor-based method using latent class analysis (LCA) and MDCs by a distribution-based method.RESULTS
All differences between means of baseline and first year postoperative total score measures for all scales demonstrated statistically significant improvements in the overall population as well as the surgically treated patients but not in the nonsurgical group. The calculated MDC and MCID values of HRQOL parameters in the entire study population were 1.34 and 2.62 for COMI, 10.65 and 14.31 for ODI, 6.09 and 7.33 for SF-36 PCS, 6.14 and 4.37 for SF-36 MCS, and 0.42 and 0.71 for SRS-22R. The calculated MCID values for surgical and non-surgical treatment groups were 2.76 versus 1.20 for COMI, 14.96 versus 2.45 for ODI, 7.83 versus 2.15 for SF-36 PCS, 5.14 versus 2.03 for SF-36 MCS, and 0.94 versus 0.11 for SRS-22R; the MDC values for surgical and nonsurgical treatment groups were 1.22 versus 1.51 for COMI, 10.27 versus 9.45 for ODI, 5.16 versus 6.77 for SF-36 PCS, 6.05 versus 5.67 for SF-36 MCS, and 0.38 versus 0.43 for SRS-22R.CONCLUSIONS
This study has demonstrated that MCID calculations for the HRQOL scales in ASD using LCA yield values comparable to other studies that had used different methodologies. The most important finding was the significantly different MCIDs for COMI, ODI, SF-36 PCS and SRS-22 in the surgically and nonsurgically treated cohorts. This finding suggests that a universal MCID value, inherent to a specific HRQOL for an entire cohort of ASD may not exist. Use of different MCIDs for surgical and nonsurgical patients may be warranted. 相似文献2.
3.
Reverberation and multiple shadow artifacts recorded from patients with intra‐pericardial centrifugal continuous‐flow left ventricular assist devices 下载免费PDF全文
4.
Rengin Çetin Güvenç Nurgül Ceran Tolga Sinan Güvenç Hacer Ceren Tokgöz Yalçin Velibey 《Journal of cardiac failure》2018,24(9):583-593
Background
Involvement of right-sided heart chambers (RSHCs) in patients infected with human immunodeficiency virus (HIV) is common and is usually attributed to pulmonary arterial or venous hypertension (PH). However, myocardial involvement in patients with HIV is also common and might affect RSHCs even in the absence of overt PH. Our aim was to define morphologic and functional alterations in RSHC in patients with HIV and without PH.Methods and Results
A total of 50 asymptomatic patients with HIV and 25 control subjects without clinical or echocardiographic signs for PH were included in the study. Transthoracic echocardiography was used to obtain measurements. Patients with HIV had significantly increased right ventricular end-diastolic diameter (RVEDD) and right ventricular free wall thickness (RVFWT), as well as increased right atrial area and pulmonary arterial diameter, compared with control subjects. After adjustment for age, sex, and body surface area, RVFWT (average 1.81 mm, 95% confidence interval [CI] 0.35–3.26 mm) and RVEDD (average 6.82 mm, 95% CI 2.40–11.24 mm) were significantly higher in subjects infected with HIV. More patients with right ventricular hypertrophy were on antiretroviral treatment, and RVFWT was on average 1.3 mm higher (95% CI 0.24–2.37 mm) in patients on antiretroviral treatment after adjustment for confounders.Conclusions
These findings suggest that alterations in RSHCs were present in patients with HIV without PH. 相似文献5.
6.
Dilek Sevimli Erkan Kozanoglu Rengin Guzel Ahmet Doganay 《Journal of Physical Therapy Science》2015,27(6):1781-1786
[Purpose] There are various treatment modalities for fibromyalgia syndrome (FMS), which
is characterized by widespread pain and fatigue. The aim of this study was to investigate
the effects of aquatic, aerobic and isometric strength-stretching exercises on the
physical and psychological parameters of patients with FMS. [Subjects and Methods] Seventy
five female patients with FMS were randomly selected and divided into three groups.
Patients (18–50 years) were treated for 3 months using one of three methods: a home-based
isometric strength and stretching exercise program (ISSEP), a gym-based aerobic exercise
program (AEP), and a pool-based aquatic aerobic exercise program (AAEP). Items evaluated
were: the number of tender points, Visual Analog Scale (VAS), Fibromyalgia Impact
Questionnaire (FIQ), the Six-Minute Walk Test (6MWT), SF-36 physical and mental health
scores, and the Beck Depression Inventory (BDI). [Results] The results revealed that AAEP
was the most effective treatment of the three. All of the groups showed significant
improvements in all variables between pre-and post-test, except the mean values of VAS and
BDI in ISSEP. [Conclusion] The results suggest that aquatic aerobic exercise program is
more effective than AEP and ISSEP in the treatment of FMS.Key words: Fibromyalgia, Exercise, Treatment 相似文献
7.
Emre Acaroglu Aysun Cetinyurek Yavuz Umit Ozgur Guler Selcen Yuksel Yasemin Yavuz Montse Domingo-Sabat Ferran Pellise Ahmet Alanay Francesco Sanchez Perez Grueso Frank Kleinstück Ibrahim Obeid European Spine Study Group 《European spine journal》2016,25(8):2390-2400
Background
Adult spinal deformity (ASD) is a major public health problem. There are pros and cons of the available treatment alternatives (surgical or non-surgical) and it had been difficult to identify the best treatment modality.Aim
To construct a statistical DA model to identify the optimum overall treatment in ASD.Methods
From an international multicentre database of ASD patients (968 pts), 535 who had completed 1 year follow-up (371 non-surgical—NS, 164 surgical—S), constitute the population of this study. DA was structured in two main steps of: (1) baseline analysis (assessing the probabilities of outcomes, assessing the values of preference—utilities-, combining information on probability and utility and assigning the quality adjusted life expectancy (QALE) for each treatment) and (2) sensitivity analysis.Results
Four hundred and thirty-two patients (309 NS, 123 S) had baseline and 1 year follow-up ODI measurements. Overall, 104 (24.1 %) were found to be improved (a decrease in ODI > 8 points), 225 (52.1 %) unchanged (?8 > ODI > 8) and 65 deteriorated. Surgery presented with a higher chance of improvement (54.2 %) versus NS (9.7 %). The overall QALE ranged from 56 to 69 (of 100 years) and demonstrated better final QALE in the NS group (60 vs. 65, P = 0.0038), this group having started with higher QALE as well (56 vs. 65 years, P < 0.0001). There were improvements in overall QALE in both groups but this was significant only in the surgical group (S from 56 to 60 years, P < 0.0001; NS from 65 to 65 years, P = 0.27). In addition, in the subgroup of patients with significant baseline disability (ODI > 25) surgery appeared to yield marginally better final QALE (58 vs. 56 years, P = 0.1) despite very a similar baseline (54 vs. 54 years, P = 0.93).Discussion and conclusions
This study demonstrated that a single best treatment modality for ASD may not exist. Conservative treatment appears to yield higher (up to 6 %) QALE compared to surgery, most probably secondary to a higher baseline QALE. On the other hand, surgery provides a significantly higher increase in QALE. Especially in patients with significant disability at baseline, the final QALE tended higher in the S group (although not significant). Finally, chances of a relevant improvement at first year turned out to be significantly lower with NS treatment.8.
9.
10.