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排序方式: 共有299条查询结果,搜索用时 140 毫秒
1.
2.
T Albrecht D J Speelman V M Ramanujam H W Lund M S Legator N M Trieff 《Teratogenesis, carcinogenesis, and mutagenesis》1980,1(2):161-169
Inactivation of the infectivity of human cytomegalovirus (CMV) and herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) has been observed following exposure to 4-nitroquinoline 1-oxide (NQO) or its metabolite, 4-hydroxyaminoquinoline 1-oxide (HAQO). The present study of the specificity of the chemical structure of 4-nitroquinolines demonstrated that both the 4-nitro and 1-oxide groups were required for inactivation of virus infectivity. Reduction of the 4-nitro group to a 4-hydroxyamino group enhanced activity, while further reduction to an amino group resulted in loss of activity against virus infectivity. The capacity to inactivate virus was also lost by substitution of the pyridine ring for the quinoline nucleus of NQO. The relationship between the chemical structure and the ability to inactivate viruses studied here correlates well with earlier in vivo carcinogenicity studies of the same group of chemicals. 相似文献
3.
M. S. Vidyasagar Suresh Rao Donald J. Fernandes Ramanujam A. S. 《Indian journal of otolaryngology and head and neck surgery》1998,50(1):69-72
Primary Ewing’s sarcoma of the nasal bone has not been previously described. This case presented as a mass in the left ala
of the nose in a five year old female child. The clinical, radiological, microscopic features are described and a review of
literature is presented. The case was treated with neoadjuvant chemotherapy and local electron beam radiation therapy. The
child was free of disease when she reported for follow up in July 1997. Although wide excision is part of the treatment approach
in Ewing’s sarcoma, in sites where surgery is not suitable local radiotherapy and chemotherapy adequately controls primary
disease. 相似文献
4.
T. M. Ramanujam A. Sergius V. Usha S. Ramanathan 《Pediatric surgery international》1998,14(1-2):134-137
Urethral duplication (UD) is an uncommon malformation. Obstruction rarely occurs in hypospadiac UD. We describe two children
with incomplete hypospadiac UD in association with posterior urethral valves, a combination not previously recognised. The
embryonic significance of this anomaly is discussed.
Accepted: 30 September 1997 相似文献
5.
M. S. Vidyasagar Suresh Rao Donald J. Fernandes A. S. Ramanujam 《Indian journal of otolaryngology and head and neck surgery》1998,50(1):69-72
Primary Ewing’s sarcoma of the nasal bone has not been previously described. This case presented as a mass in the left ala of the nose in a five year old female child. The clinical, radiological, microscopic features are described and a review of literature is presented. The case was treated with neoadjuvant chemotherapy and local electron beam radiation therapy. The child was free of disease when she reported for follow up in July 1997. Although wide excision is part of the treatment approach in Ewing’s sarcoma, in sites where surgery is not suitable local radiotherapy and chemotherapy adequately controls primary disease. 相似文献
6.
7.
Manju Bhargavi Gumpu Noel Nesakumar Srinidhi Nagarajan Sadhana Ramanujam Uma Maheswari Krishnan K. Jayanth Babu John Bosco Balaguru Rayappan 《Bulletin of environmental contamination and toxicology》2017,98(5):662-671
Acetylcholinesterase (AChE) enzyme has been predominantly used for the detection of pesticides and metal ions. But, these sensors respond to pesticides as well as metal ions at certain concentration, which results in poor selectivity. Hence in this work, the amount of thiocholine produced during AChE inhibition has been estimated to detect the residual activity of AChE enzyme in-turn to enhance the efficiency of the biosensor. In this context, Pt/ZnO–CeO2/AChE/Chitosan based biosensor has been developed for sensitive voltammetric quantification of thiocholine in AChE. The sensor exhibited enhanced electron transfer rate, good conductivity and biocompatibility. Both the intrinsic and extrinsic parameters were simultaneously optimized using second order polynomial regression to get the best conditions for ATCh determination. Under optimized experimental conditions, the redox peak current was linear over the concentration range of 0.1–1.5 mM with detection and quantification limit of 0.05 and 0.15 μM respectively and the sensitivity of 1.47 μA mM?1. 相似文献
8.
P. S. Ramanujam M.D. K. S. Venkatesh M.D. T. Co Barnett M.D. M. J. Fietz M.D. 《Diseases of the colon and rectum》1996,39(1):37-39
PURPOSE: The purpose of this study was to determine the incidence of human papillomavirus deoxyribonucleic acid (HPV DNA) in anal squamous carcinoma. METHODS: HPV DNA in situ hybridization for HPV Types 6, 11, 16, 18, 31, 33, and 35 was performed on the formalin-fixed, paraffinembedded tissue from 53 perianal and anal squamous carcinomas and 10 controls. RESULTS: HPV DNA sequences were identified in 18 of 53 anal squamous carcinomas (34 percent). All 10 controls were negative for HPV DNA. Of the 18 positive patients, 10 were perianal squamous carcinomas, and 8 were anal canal squamous carcinomas. Six of the perianal carcinomas were positive for HPV Types 6 and 11. The remaining four perianal carcinomas and all eight of the anal canal carcinomas were positive for HPV Types 16 and 18. CONCLUSION: HPV DNA sequences can be identified in anal squamous carcinomas. Anal squamous epithelium is another site where HPV infection may carry a risk for malignant transformation. One-third of anal squamous carcinomas may be associated with prior HPV infection. Patients with anogenital HPV infection should be routinely screened for anal squamous lesions. 相似文献
9.
10.
Perianal abscesses and fistulas 总被引:2,自引:0,他引:2
Paravasthu S. Ramanujam M.D. M. Leela Prasad M.D. Dr. Herand Abcarian M.D. Ana B. Tan R.N. E.T. 《Diseases of the colon and rectum》1984,27(9):593-597
In a five and one-half year period, 1023 patients with anorectal abscesses and fistulas were treated. Under regional anesthesia
the abscesses were unroofed and debrided and a primary fistulotomy was performed whenever a low fistula was identified. In
355 (34.7 per cent) an internal fistulous opening was demonstrated at the time of abscess drainage. Thirty-two patients had
suprashincteric fistulas and underwent two-stage fistulotomy using a seton. Perianal abscesses were encountered in 42.7 per
cent of the patients, followed by ischiorectal (22.7 per cent), intersphincteric (21.4 per cent), and supralevator (7.33 per
cent). The patients with supralevator and intersphincteric abscesses had a high incidence of fistula identified during abscess
drainage. The recurrence rates were 3.7 per cent in the group with abscess drainage only and 1.8 per cent in the group that
had primary fistulotomy along with abscess drainage. The follow-up period averaged 36 months. To accomplish adequate drainage
and identify the deeper components and associated fistulous opening (34.7 per cent of the entire group), careful examination
under regional anesthesia is recommended. Early aggressive treatment of an anorectal abscess and fistula significantly reduces
the possibility of recurrent abscesses and/or the need for further surgery.
Read at the meeting of The American Society of Colon and Rectal Surgeons, Boston, Massachusetts, June 5 to 9, 1983.
Recipient of the 1983 Rowell Laboratories Education Committee Award. 相似文献