全文获取类型
收费全文 | 667篇 |
免费 | 40篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 35篇 |
妇产科学 | 34篇 |
基础医学 | 120篇 |
口腔科学 | 12篇 |
临床医学 | 44篇 |
内科学 | 99篇 |
皮肤病学 | 9篇 |
神经病学 | 41篇 |
特种医学 | 7篇 |
外科学 | 67篇 |
综合类 | 17篇 |
预防医学 | 61篇 |
眼科学 | 13篇 |
药学 | 59篇 |
中国医学 | 6篇 |
肿瘤学 | 77篇 |
出版年
2023年 | 5篇 |
2022年 | 25篇 |
2021年 | 27篇 |
2020年 | 23篇 |
2019年 | 24篇 |
2018年 | 17篇 |
2017年 | 20篇 |
2016年 | 27篇 |
2015年 | 24篇 |
2014年 | 29篇 |
2013年 | 34篇 |
2012年 | 68篇 |
2011年 | 60篇 |
2010年 | 17篇 |
2009年 | 19篇 |
2008年 | 29篇 |
2007年 | 25篇 |
2006年 | 32篇 |
2005年 | 44篇 |
2004年 | 39篇 |
2003年 | 35篇 |
2002年 | 24篇 |
2001年 | 6篇 |
2000年 | 1篇 |
1999年 | 5篇 |
1998年 | 2篇 |
1997年 | 4篇 |
1996年 | 2篇 |
1995年 | 1篇 |
1994年 | 3篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 4篇 |
1990年 | 2篇 |
1989年 | 1篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1985年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1973年 | 1篇 |
1938年 | 1篇 |
1936年 | 1篇 |
1918年 | 1篇 |
1912年 | 1篇 |
排序方式: 共有709条查询结果,搜索用时 15 毫秒
1.
Sera from 130 first trimester pregnant women were tested for their serum antibody level against a naturally occurring serum antigen purified from non-pregnancy sera. IgG and IgM antibody level was measured using enzyme linked immunosorbant assay. Results indicate that patients with multiple abortion (n=26) have significantly (p=0.0029) lower level of IgG antibody and significantly (p=0.0001) higher level of IgM antibodies; against the serum antigen as compared to the patients with successful pregnancies with no history of miscarriage (n=63). Western blot analysis identified the scrum antigen recognized by the IgM antibody as a 24 kDa molecular mass component. These IgG and IgM antibodies may play an important role in the outcome of pregnancy. 相似文献
2.
3.
4.
Faridimehr Sina Venkatachalam Saravanan Chinnam Ratna Babu 《Health care management science》2021,24(3):482-498
Health Care Management Science - An important challenge confronting healthcare is the effective management of access to primary care. Appointment scheduling policies/templates can help strike an... 相似文献
5.
Phaniendra Kumar V Srinivasa Murthy M Ravikanth S. Ratna Kumar 《Indian journal of otolaryngology and head and neck surgery》2003,55(3):184-186
Benign lesions of glottis creates stiffness of the vocal fold and inefficient glottal valve, aerodynamically effecting the
vocal quality by preventing smooth vocal edge closure. Introduction of phonomicrosurgical techniques based on Hirano ’s principle
of vocal fold epithelium have revolutionized results of voice surgery. Our experience in the management of benign vocal fold
lesions by phonomicrosurgical techniques with pre and post operative stroboscopic, perceptual and computerized acoustic voice
analysis is described. 相似文献
6.
Robert M Kessler Mohammad Sib Ansari Patrizia Riccardi Rui Li Karuna Jayathilake Benoit Dawant Herbert Y Meltzer 《Neuropsychopharmacology》2005,30(12):2283-2289
There have been conflicting reports as to whether olanzapine produces lower occupancy of striatal dopamine D(2)/D(3) receptor than typical antipsychotic drugs and preferential occupancy of extrastriatal dopamine D(2)/D(3) receptors. We performed [(18)F] fallypride PET studies in six schizophrenic subjects treated with olanzapine and six schizophrenic subjects treated with haloperidol to examine the occupancy of striatal and extrastriatal dopamine receptors by these antipsychotic drugs. [(18)F] setoperone PET studies were performed in seven olanzapine-treated subjects to determine 5-HT(2A) receptor occupancy. Occupancy of dopamine D(2)/D(3) receptors by olanzapine was not significantly different from that seen with haloperidol in the putamen, ventral striatum, medial thalamus, amygdala, or temporal cortex, that is, 67.5-78.2% occupancy; olanzapine produced no preferential occupancy of dopamine D(2)/D(3) receptors in the ventral striatum, medial thalamus, amygdala, or temporal cortex. There was, however, significantly lower occupancy of substantia nigra/VTA dopamine D(2)/D(3) receptors in olanzapine-treated compared to haloperidol-treated subjects, that is, 40.2 vs 59.3% (p=0.0014, corrected for multiple comparisons); in olanzapine-treated subjects, the substantia nigra/VTA was the only region with significantly lower dopamine D(2)/D(3) receptor occupancy than the putamen, that is, 40.2 vs 69.2% (p<0.001, corrected for multiple comparison). Occupancy of 5-HT(2A) receptors was 85-93% in the olanzapine- treated subjects. The results of this study demonstrated that olanzapine does not produce preferential occupancy of extrastriatal dopamine D(2)/D(3) receptors but does spare substantia nigra/VTA receptors. Sparing of substantia nigra/VTA dopamine D(2)/D(3) receptor occupancy may contribute to the low incidence of extrapyramidal side effects in olanzapine-treated patients. 相似文献
7.
The clinical relevance of steroid hormone receptor corepressors. 总被引:2,自引:0,他引:2
Rakesh Kumar Anupama E Gururaj Ratna K Vadlamudi Suresh K Rayala 《Clinical cancer research》2005,11(8):2822-2831
8.
9.
10.
Pooja Srivastava Shilpa Mohanti Dnyaneshwar Umrao Bawankule Feroz Khan Karuna Shanker 《Naunyn-Schmiedeberg's archives of pharmacology》2014,387(2):119-127
Neuroinflammation plays a significant role in various chronic and acute pathological conditions of the central nervous system. In the Indian system of medicine, Pluchea lanceolata is used to treat the neurological disorders. We investigated the effect of major pentacyclic triterpene and its naturally occurring acetate derivative isolated from P. lanceolata on lipopolysaccharide (LPS)-stimulated neuroinflammatory condition associated to inflammatory cytokine production in rat astrocytoma cell line (C6). The log concentration dependence of Pluchea bioactive taraxasterol (Tx) significantly (p?<?0.05) attenuates the release of pro-inflammatory cytokines, such as TNF-α, IFN-γ, and IL-6, while its in situ produced acetyl derivative, i.e., taraxasterol acetate (TxAc), did not inhibit the LPS-induced IL-6 production at lower concentration (p?>?0.05). Surflex-Dock molecular modeling study was performed to simulate the binding capacity of compounds into the active site of the TNF-α (2AZ5), tumor protein P53 (2VUK), and NF-kappa-B (1RAM). The differential inhibition of cytokines by Tx and TxAc was further confirmed by high docking scores showing the high affinity to target proteins. Findings of the study demonstrated the comparatively greater role of Pluchea triterpene than its in situ produced acetate derivate in neuroinflammation-associated disorders. 相似文献