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Septic discitis refers to a primary suppurative process involving the intervertebral disc space and occurs as a result of hematogenous invasion or contamination by pyogenic organisms. A case of septic discitis is described in a 77-year-old woman following an episode of Escherichia coli urosepsis. Despite bed rest, an orthosis, and appropriate antibiotics, the patient ultimately had to undergo surgical disc removal. The diagnosis of septic discitis is often made in the context of other diseases that share common clinical and laboratory findings. Magnetic resonance imaging appears well suited for diagnostic confirmation of septic discitis. Needle biopsy and aspiration results should be used to determine the appropriate choice of antibiotic for this disease process. 相似文献
3.
Gardenia C. G. Militão Daniel P. Bezerra Claudia Pessoa Manoel Odorico de Moraes Flavio A. F. da Ponte Mary Anne S. Lima Edilberto R. Silveira Letícia V. Costa-Lotufo 《Journal of natural medicines》2007,61(2):196-199
The purpose of this study was to investigate the antiproliferative activity of 2,3,9-trimethoxypterocarpan, a known pterocarpan
with cytotoxic activity against many tumor cell lines, in a panel of four leukemia cell lines (HL-60, Molt-4, Jurkat, and
K562) and on human peripheral blood mononuclear cells (PBMC). The pterocarpan showed IC50 ranging from 0.1 to 0.5 μg/ml at leukemic cells after 72 h of incubation, with K562 being the most resistant cell line. This
compound seemed to be selective to tumor cell lines, since at a concentration of 10 μg/ml after 72 h, it only reduced 19%
of viable peripheral mononuclear cells. 相似文献
4.
Jean -Pierre Bénitah Patrick Bailly Marie -Claire D'Agrosa Jean -Philippe Da Ponte Carmen Delgado Paco Lorente 《Pflügers Archiv : European journal of physiology》1992,421(2-3):176-187
Characteristics of the slow inward current (I
si) in human ventricular myocytes isolated from septal specimens obtained in patients undergoing corrective cardiac surgery were studied using the whole-cell clamp method. A first series of experiments was performed under normal standard superfusion. Clamping from –60 mV evoked an inward current with a threshold at about –35 mV, a maximum around +10 mV and an apparent reversal potential at about +55 mV. No overlapping transient or background outward currents were detected in the –60 to +30 mV potential range, but time-dependent and steady-state outward currents were elicited at potentials above +30 mV. An overlap of steady-state activation and inactivation curves was present between –30 and +10 mV and a slight relief from inactivation was observed for voltages positive to +10mV. The time course of inactivation consisted of fast and slow phases with time constants differing by a factor of eight. Slow time constants of inactivation were shorter at potentials that elicited larger I
si, and longer at potentials inducing smaller I
si. Recovery from inactivation evolved slowly with 100% reactivation occurring in about 4000 ms. Switching the holding potential from –60 to –40 mV led to a reversible decline of I
si without any change of the decay time constants. I
si was significantly increased by 0.1 M isoproterenol. Total or partial inhibition by inorganic (2 mM Mn2+, 3 mM Co2+, 1 mM Cd2+) and organic (1 M methoxyverapamil, 5 M diltiazem) calcium antagonists did not unmask any transient outward current. However, a consistent increase of I
si was reversibly observed with 3 mM 4-aminopyridine while using standard solutions. A second series of experiments carried out with K+- and Na+-free solutions did not demonstrate any significant change from data observed with standard solutions except a reduction of outward currents at steps above +30 mV and alteration of inactivation kinetics. In this experimental setting, 4-aminopyridine also increased I
si but to a lesser degree. We conclude that I
si, as compared to the outward currents, is dominant in the diseased human ventricular cells we have studied. 相似文献
5.
Paola Queirolo MD Marco Ponte MD Marco Gipponi MD Ferdinando Cafiero MD Alberto Peressini MD Claudia Semino PhD Gabriella Pietra PhD Rita Lionetto MD Stefania Vecchio MD Iole Ribizzi MD Giovanni Melioli MD Mario R. Sertoli MD 《Annals of surgical oncology》1999,6(3):272-278
Background: On the basis of our previous experience, we designed this study to determine the activity and toxicity of outpatient treatment with autologous tumor-infiltrating lymphocytes (TIL) together with intermediate-dose recombinant interleukin-2 (rIL-2) and low-dose recombinant interferon alfa-2a (rIFN-2a), for patients with metastatic melanoma.Methods: Between April 1992 and October 1994, we processed 38 melanoma samples derived from 36 patients with metastases. Proliferative cultures of expanded lymphocytes (TIL) were infused only once into patients with metastatic melanoma. rIL-2 was administered subcutaneously for 1 month, starting on the day of TIL infusion, at an escalating dose of 6–18 × 106 IU/m2/day for the first week and at the maximum-tolerated dose for the subsequent 3 weeks and then, after a 15-day interval, for 1 week/month for 3 months. rIFN-2a was administered subcutaneously at 3 × 106 IU three times each week until progression.Results: Of 38 melanoma samples, 19 (50%) resulted in proliferative cultures and were infused. The median number of expanded lymphocytes was 18 × 109 (range, 1–43 × 109), and the median period of culture was 52 days (range, 45–60). rIL-2 was administered at doses ranging between 6 and 18 × 106 IU/m2/day. Toxicity was mild or moderate, and no life-threatening side effects were encountered. Two of 19 treated patients experienced complete responses of their metastatic sites (soft tissue), 10 had stable disease, and 7 showed progressive disease. The response rate was 11% (95% confidence interval, 2–35%).Conclusions: Outpatient treatment with TIL plus rIL-2 and rIFN-2a is feasible, although, within the context of the small sample size, the activity of the combination was no different from the reported activity of any of the components used alone. 相似文献
6.
In a prospective, randomized, controlled study, we have investigated the
effect of forced air warming on the rate of change of nasopharyngeal and
rectal temperatures in 20 patients after coronary artery bypass grafting.
All patients had nasopharyngeal temperatures less than 36 degrees C on
arrival in the intensive care unit and received an infusion of glyceryl
trinitrate 15 mg h-1, but none received inotropes. Ten patients were warmed
under an aluminized plastic "space" blanket (control group) and 10 were
warmed under a "Bair Hugger" blanket connected to its power unit on "high"
setting (Bair Hugger group). The rates of increase in nasopharyngeal
temperature were 0.4 and 0.95 degrees C h-1, respectively, in the control
and Bair Hugger groups (P < 0.01) during the first 2 h after operation.
Over the same period of time, rectal temperatures increased at a rate of
0.25 and 0.75 degrees C h-1 in the control and Bair Hugger groups,
respectively (P < 0.01).
相似文献
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Fonseca Eduardo Kaiser Ururahy Nunes Ponte Marco Philipe Teles Reis Yamauchi Fernando Ide Baroni Ronaldo Hueb 《Abdominal imaging》2017,42(11):2779-2779
Abdominal Radiology - 相似文献
10.