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排序方式: 共有150条查询结果,搜索用时 15 毫秒
1.
Peep Algvere 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1976,201(2):123-134
Summary By means of a micro-surgical technique, the central retinal artery of the owl monkey (Aotus trivirgatus) was embolized with spheric plastic beads (7–25 in diameter). Beads (4–15 ) were also injected into choroidal capillaries through a supero-temporal vortex vein.Choroidal ischemia induced proliferation or degeneration of the pigment epithelium, frequently accompanied by photoreceptor degeneration and circumscribed retinal detachment. Occlusion of retinal vessels resulted in posterior vitreous detachment and micro-cystoid degeneration in inner retinal layers, followed by retinal schisis. In combined retinal and choroidal ischemia long-lasting retinal detachments regularly developed.Supported by U.S. Public Health Service Fogarty International Fellowship IFO5 TWO1799-01 and the Swedish Medical Research Council (Project B72-60R-3655) 相似文献
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L Banci I Bertini F Cantini T Kozyreva C Massagni P Palumaa JT Rubino K Zovo 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(34):13555-13560
Copper chaperone for superoxide dismutase 1 (SOD1), CCS, is the physiological partner for the complex mechanism of SOD1 maturation. We report an in vitro model for human CCS-dependent SOD1 maturation based on the study of the interactions of human SOD1 (hSOD1) with full-length WT human CCS (hCCS), as well as with hCCS mutants and various truncated constructs comprising one or two of the protein's three domains. The synergy between electrospray ionization mass spectrometry (ESI-MS) and NMR is fully exploited. This is an in vitro study of this process at the molecular level. Domain 1 of hCCS is necessary to load hSOD1 with Cu(I), requiring the heterodimeric complex formation with hSOD1 fostered by the interaction with domain 2. Domain 3 is responsible for the catalytic formation of the hSOD1 Cys-57-Cys-146 disulfide bond, which involves both hCCS Cys-244 and Cys-246 via disulfide transfer. 相似文献
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Obi T. Okoye Peep Talving Pedro G. Teixeira Michael Chervonski Jennifer A. Smith Kenji Inaba Thomas T. Noguchi Demetrios Demetriades 《Injury》2013
Background
Transmediastinal gunshot wounds are associated with a high mortality and frequently require operative intervention. The purpose of this study was to identify the diagnostic and therapeutic challenges of these injuries in a mature trauma system with decreasing prehospital time intervals.Methods
Patients admitted to a large urban Level 1 trauma centre between 1/2006 and 12/2010 sustaining a firearm injury to the torso were identified. Transmediastinal gunshot wounds were defined as missile tracts traversing the mediastinum identified on CT images, operative notes or autopsy reports.Results
Overall, 133 patients met study criteria. A total of 116 patients (87.2%) were haemodynamically unstable or had no vital signs on arrival to the Emergency Department. Ninety-seven (83.6%) of these patients required a resuscitative thoracotomy resulting in 8 survivors (6.0%). There were 17 haemodynamically stable patients (12.8%) identified, 14 of whom underwent CT scan evaluation. Six patients subsequently required operative intervention. Only 11 patients (8.3%) in the study population were successfully managed nonoperatively. The overall mortality was 78.9%, and for those who reached the hospital with vital signs, the mortality was 24.3%.Conclusions
Transmediastinal gunshot wounds encountered in a mature trauma centre are highly lethal injuries requiring resuscitative thoracotomy in most instances. Changing perspectives in these injuries may reflect the effects of an evolving prehospital care. 相似文献7.
Maria Volokhova Anna Shugai Masahiko Tsujimoto Anna-Liisa Kubo Sven Telliskivi Mait Nigul Peep Uudeküll Heiki Vija Olesja M. Bondarenko Jasper Adamson Anne Kahru Raivo Stern Liis Seinberg 《Materials》2022,15(6)
Nanoparticles with SiO coating were synthesized to have a cubic iron core. These were found to have saturation magnetization very close to the highest possible value of any iron-containing nanoparticles and the bulk iron saturation magnetization. The in vitro toxicology studies show that they are highly biocompatible and possess better MRI contrast agent potential than iron oxide NPs. 相似文献
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Stalmeier PF de Boer AG Sprangers MA de Haes HC van Lanschot JJ 《International journal of technology assessment in health care》2005,21(1):113-118
OBJECTIVES: The convergent validity between utility assessment methods was assessed. METHODS: Investigated were patients with esophageal cancer treated surgically with curative intent. Patients were interviewed in a period from 3 to 12 months after surgical resection. Patients evaluated their actual health and seven other states. Visual analogue scale (VAS) and standard gamble (SG) utilities were obtained for the health states in an interview. Patients also indicated whether or not they preferred death to living in a health state (worse than dead [WTD] preferences). RESULTS: Fifty patients completed the interview. Convergent validity was excellent at the aggregate and individual level. However, the relation between VAS and SG differed strongly across individuals. On a scale from 0 (dead) to 100 (perfect health), SG scores were lower for patients with WTD preferences (mean difference d = 35; p = .002); however, VAS scores did not vary by WTD preferences. CONCLUSIONS: In general, there is good agreement between VAS and SG measures, although patients disagree about how the VAS and SG are related. The standard gamble varied by WTD preferences, however, the VAS did not. 相似文献
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Linda J. M. Oostendorp Petronella B. Ottevanger Agnes J. van de Wouw Aafke H. Honkoop Maartje Los Winette T. A. van der Graaf Peep F. M. Stalmeier 《Journal of cancer education》2016,31(3):443-448
Communication about palliative treatment options requires a balance between providing patients with sufficient information and not providing unwanted information. Surveys have indicated that many patients with advanced cancer express a wish to receive detailed information. In this prospective multicenter study, the information desire of patients with advanced breast or colorectal cancer was further investigated by offering treatment-related information to patients using a decision aid (DA). In addition, this study explored oncologists’ awareness of their patients’ information desire. Seventy-seven patients with advanced breast or colorectal cancer facing the decision whether to start second-line palliative chemotherapy were offered a DA by a nurse. This DA contained information on adverse events, tumor response, and survival. The nurse asked the patient whether each information item was desired. Ninety-five percent of patients chose to receive information on adverse events, 91 % chose to receive information on tumor response, and 74 % chose to receive information on survival. Oncologists’ judgment of patients’ information desire was 100, 97, and 81 %, respectively. For all three information items together, oncologists correctly judged the information desire of 62 % of patients. This study confirms that many patients with advanced cancer wish to receive detailed information on the benefits and risks of palliative treatment options when the information is actually available. Oncologists were adequately aware of this high information desire, but had some difficulty judging the information desire of individual patients. A stepped approach to giving information (“preview, ask, tell, ask”) may help to better meet patients’ information needs. 相似文献