全文获取类型
收费全文 | 6424篇 |
免费 | 1062篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 51篇 |
儿科学 | 186篇 |
妇产科学 | 102篇 |
基础医学 | 691篇 |
口腔科学 | 26篇 |
临床医学 | 1556篇 |
内科学 | 1921篇 |
皮肤病学 | 119篇 |
神经病学 | 467篇 |
特种医学 | 179篇 |
外科学 | 621篇 |
综合类 | 19篇 |
一般理论 | 2篇 |
预防医学 | 697篇 |
眼科学 | 41篇 |
药学 | 363篇 |
中国医学 | 7篇 |
肿瘤学 | 475篇 |
出版年
2024年 | 20篇 |
2023年 | 162篇 |
2022年 | 125篇 |
2021年 | 163篇 |
2020年 | 227篇 |
2019年 | 125篇 |
2018年 | 285篇 |
2017年 | 243篇 |
2016年 | 282篇 |
2015年 | 300篇 |
2014年 | 385篇 |
2013年 | 414篇 |
2012年 | 396篇 |
2011年 | 401篇 |
2010年 | 329篇 |
2009年 | 399篇 |
2008年 | 397篇 |
2007年 | 353篇 |
2006年 | 334篇 |
2005年 | 404篇 |
2004年 | 371篇 |
2003年 | 333篇 |
2002年 | 276篇 |
2001年 | 64篇 |
2000年 | 61篇 |
1999年 | 84篇 |
1998年 | 100篇 |
1997年 | 56篇 |
1996年 | 63篇 |
1995年 | 60篇 |
1994年 | 40篇 |
1993年 | 47篇 |
1992年 | 22篇 |
1991年 | 29篇 |
1990年 | 24篇 |
1989年 | 15篇 |
1988年 | 23篇 |
1987年 | 23篇 |
1986年 | 11篇 |
1985年 | 13篇 |
1984年 | 7篇 |
1983年 | 11篇 |
1982年 | 13篇 |
1981年 | 8篇 |
1980年 | 8篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 5篇 |
1974年 | 2篇 |
1972年 | 2篇 |
排序方式: 共有7523条查询结果,搜索用时 15 毫秒
1.
2.
3.
Worsening pneumonitis due to a pharmacokinetic drug–drug interaction between everolimus and voriconazole in a renal transplant patient
下载免费PDF全文
![点击此处可从《Journal of clinical pharmacy and therapeutics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
4.
5.
Prevalence of Potentially Inappropriate Prescribing Among Hong Kong Older Adults: A Comparison of the Beers 2003, Beers 2012, and Screening Tool of Older Person's Prescriptions and Screening Tool to Alert doctors to Right Treatment Criteria
下载免费PDF全文
![点击此处可从《Journal of the American Geriatrics Society》网站下载免费的PDF全文](/ch/ext_images/free.gif)
6.
Thierry Patrice David Olivier Ludovic Bourre 《Journal of environmental pathology, toxicology and oncology》2006,25(1-2):467-485
Photodynamic therapy (PDT) is based on the selective light activation of an exogenously given drug to patients. PDT acts mainly on cell membranes either of neovascular endothelial cells or of cancer cells leading to cancer cell death. Six drugs are now marketed based on clinical assays in various indications, which showed a clear cost efficiency as compared to other classical procedures. PDT is easy to handle and can be performed in medical installations fitting the conditions of health care in developing countries. Its cost effectiveness could represent an appropriate solution to the increasing number of cancers of various origin. However despite all the clinical results now available, PDT development remains slow. The reasons for this situation include cost of development, intellectual property, and competition between pharmaceutical companies. 相似文献
7.
Chukwuka C Okafor Hana Haleem-Smith Patrice Laqueriere Paul A Manner Rocky S Tuan 《Journal of orthopaedic research》2006,24(3):461-473
Continual loading and articulation cycles undergone by metallic (e.g., titanium) alloy arthroplasty prostheses lead to liberation of a large number of metallic debris particulates, which have long been implicated as a primary cause of periprosthetic osteolysis and postarthroplasty aseptic implant loosening. Long-term stability of total joint replacement prostheses relies on proper integration between implant biomaterial and osseous tissue, and factors that interfere with this integration are likely to cause osteolysis. Because multipotent mesenchymal stem cells (MSCs) located adjacent to the implant have an osteoprogenitor function and are critical contributors to osseous tissue integrity, when their functions or activities are compromised, osteolysis will most likely occur. To date, it is not certain or sufficiently confirmed whether MSCs endocytose titanium particles, and if so, whether particulate endocytosis has any effect on cellular responses to wear debris. This study seeks to clarify the phenomenon of titanium endocytosis by human MSCs (hMSCs), and investigates the influence of endocytosis on their activities. hMSCs incubated with commercially pure titanium particles exhibited internalized particles, as observed by scanning electron microscopy and confocal laser scanning microscopy, with time-dependent reduction in the number of extracellular particles. Particulate endocytosis was associated with reduced rates of cellular proliferation and cell-substrate adhesion, suppressed osteogenic differentiation, and increased rate of apoptosis. These cellular effects of exposure to titanium particles were reduced when endocytosis was inhibited by treatment with cytochalasin D, and no significant effect was seen when hMSCs were treated only with conditioned medium obtained from particulate-treated cells. These findings strongly suggest that the biological responses of hMSCs to wear debris are triggered primarily by the direct endocytosis of titanium particulates, and not mediated by secreted soluble factors. In this manner, therapeutical approaches that suppress particle endocytosis could reduce the bioreactivity of hMSCs to particulates, and enhance long-term orthopedic implant prognosis by minimizing wear-debris periprosthethic osteolysis. 相似文献
8.
Laurent Boyer Patrice Francois Elisabeth Doutre Georges Weil Jose Labarere 《International journal for quality in health care》2006,18(5):359-364
OBJECTIVE: . The aim of this study was to assess clinical staff's opinions on the results of in-patient satisfaction surveys and their use within the quality improvement process. SETTING: The institution is a 2200-bed teaching hospital of tertiary health care employing 8000 professionals. Patient satisfaction surveys are carried out each year using a validated questionnaire mailed to a random sample of patients. The specific results of each department are sent to the medical and paramedical managers. METHODS: We conducted a questionnaire survey on 500 care providers randomly selected in every medical and surgical department. RESULTS: A total of 261 questionnaires were returned and analysed. Overall, 94% of responders had a favourable opinion of the patient satisfaction surveys. They considered that the patient was able to judge hospital service quality, especially in its relational, organizational, and environmental dimensions. The specific results for the department were less well known than the overall hospital results (60 versus 76%). These results were formally discussed in the department according to 40% of responders; 40% declared that these data resulted in improvement actions and considered that they led to modifications in their behaviour with patients. CONCLUSIONS: Despite a declared interest in satisfaction surveys, the results remain underused by hospital staff and insufficiently discussed within teams. 相似文献
9.