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Stefan T. Schwarz MD MRCP Timothy Rittman BMedSci BMBS PGCertMedEd MRCP Vamsi Gontu MRCP Paul S. Morgan PhD Nin Bajaj PhD Dorothee P. Auer PhD 《Movement disorders》2011,26(9):1633-1638
Depigmentation of the substantia nigra is a conspicuous pathological feature of Parkinson's disease and related to a loss of neuromelanin. Similar to melanin, neuromelanin has paramagnetic properties resulting in signal increase on specific T1‐weighted magnetic resonance imaging. The aim of this study was to assess signal changes in the substantia nigra in patients with Parkinson's disease using an optimized neuromelanin‐sensitive T1 scan. Ten patients with Parkinson's disease and 12 matched controls underwent high‐resolution T1‐weighted magnetic resonance imaging with magnetization transfer effect at 3T. The size and signal intensity of the substantia nigra pars compacta were determined as the number of pixels with signal intensity higher than background signal intensity + 3 standard deviations and regional contrast ratio. Patients were subclassified as early stage (n = 6) and late stage (n = 4) using the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Parkinson's disease staging scale. The T1 hyperintense area in the substantia nigra was substantially smaller in patients compared with controls (?60%, P < .01), and contrast was reduced (?3%, P < .05). Size reduction was even more pronounced in more advanced disease (?78%) than in early‐stage disease (?47%). We present preliminary findings using a modified T1‐weighted magnetic resonance imaging technique showing stage‐dependent substantia nigra signal reduction in Parkinson's disease as a putative marker of neuromelanin loss. Our data suggest that reduction in the size of neuromelanin‐rich substantia nigra correlates well with postmortem observations of dopaminergic neuron loss. Further validation of our results could potentially lead to development of a new biomarker of disease progression in Parkinson's disease. © 2011 Movement Disorder Society 相似文献
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Richard N Schlegel MD PhD BBiomedSc Mark Fitzgerald MBBS MD GradDipInetComm FACEM AFRACMA Andrew Lim MBBS BPharm Gerard M O'Reilly MBBS MPH MBiostat AStat FACEM PhD Warren Clements BBiomedSc MBBS FRANZCR EBIR Gerard S Goh MBBS FRANZCR FCIRSE FSIR EBIR Christopher J Groombridge MBBS MA MSc DOHNS DRTM DIMC MRCS FACEM Cecil Johnny MBBS MS FACEM Michael P Noonan MBChB BPhty PGCertMedEd FACEM Ee-Jun Ban MBBS BMedSc FRACS Joseph Mathew MBBS MS FACEM 《Emergency medicine Australasia : EMA》2023,35(1):56-61
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Rebekka Syrjanen BSc BPharm Jennifer Schumann BSc PhD John Fitzgerald BSc PhD Dimitri Gerostamoulos BSc PhD FFCP Rachelle Abouchedid MBBS DipMedTox Diploma RANZCOG FACEM Joe-Anthony Rotella BSc MBBS MMedTox FACEM Jonathan Knott MBBS MClinEd FACEM PhD Jacqueline Maplesden MBChB FACEM DipObs PGCertMedEd PGCertMedTox Hans Hollerer MD FRACGP FACEM Liam Hannon MB BCh BAO MPHTM FACEM Elyssia Bourke MBBS BMedSc MPHTM Sarah E Hodgson MBChB FACEM Shaun L Greene MBChB MSc FACEM FACMT 《Emergency medicine Australasia : EMA》2023,35(1):82-88
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