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VASSILIOS VASSILIKOS GEORGE DAKOS IOANNA CHOUVARDA LABROS KARAGOUNIS HARALAMBOS KARVOUNIS NIKOLAOS MAGLAVERAS SOTIRIOS MOCHLAS PANAGIOTIS SPANOS GEORGE LOURIDAS 《Pacing and clinical electrophysiology : PACE》2003,26(1P2):305-309
VASSILIKOS V., et al. : Can P Wave Wavelet Analysis Predict Atrial Fibrillation After Coronary Artery Bypass Grafting? The purpose of this study was the evaluation of Morlet wavelet analysis of the P wave as a means of predicting the development of atrial fibrillation (AF) in patients who undergo coronary artery bypass grafting (CABG). The P wave was analyzed using the Morlet wavelet in 50 patients who underwent successful CABG. Group A consisted of 17 patients, 12 men and 5 women, of mean age 66.9 ± 5.9 years , who developed AF postoperatively. Group B consisted of 33 patients, 29 men and 4 women, mean age 62.4 ± 7.8 years , who remained arrhythmia-free. Using custom-designed software, P wave duration and wavelet parameters expressing the mean and maximum energy of the P wave were calculated from 3-channel digital recordings derived from orthogonal ECG leads (X, Y, and Z), and the vector magnitude (VM) was determined in each of 3 frequency bands (200–160 Hz, 150–100 Hz and 90–50 Hz). Univariate logistic-regression analysis identified a history of hypertension, the mean and maximum energies in all frequency bands along the Z axis, the mean and maximum energies (expressed by the VM) in the 200–160 Hz frequency band, and the mean energy in the 150–100 Hz frequency band along the Y axis as predictors for post-CABG AF. Multivariate analysis identified hypertension, ejection fraction, and the maximum energies in the 90–50 Hz frequency band along the Z and composite-vector axes as independent predictors. This multivariate model had a sensitivity of 91% and a specificity of 65%. We conclude that the Morlet wavelet analysis of the P wave is a very sensitive method of identifying patients who are likely to develop AF after CABG. The occurrence of post-CABG AF can be explained by a different activation pattern along the Z axis. (PACE 2003; 26[Pt. II]:305–309) 相似文献
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JENNIFER R. ALLPORT LOUISE E DONNELLY PANAGIOTIS KEFALAS GAR LO ALISTAIR NUNN MASOUD YADOLLAHI-FARSANI NIGEL B. RENDELL STEPHEN MURRAY GRAHAM W. TAYLOR & JOHN MACDERMOT 《British journal of clinical pharmacology》1996,42(1):99-106
1 Mono(ADP-ribosyl)transferase activity has been identified on the external surface of human polymorphonuclear neutrophil leucocytes (PMNs). The enzyme is released from the plasma membrane by phosphoinositide-specific phospholipase C, suggesting a glycosylphosphatidylinositol (GPI) linkage of the enzyme to the plasma membrane. Partial sequence of cDNA encoding the enzyme suggests that it is identical to the GPI-linked mono(ADP-ribosyl)transferase identified previously on human skeletal muscle.
2 A panel of inhibitors of mono(ADP-ribosyl)transferase (including vitamins K1 and K3 , novobiocin and nicotinamide) showed a rank order of inhibitory potency similar to that described for other mono(ADP-ribosyl)transferases. Furthermore, the mono(ADP-ribosyl)ation of agmatine was inhibited also by diethylamino(benzylidineamino)guanidine (DEA-BAG), another substrate of the enzyme related structurally to arginine.
3 There was a close linear correlation between the I C50 values for inhibition of mono(ADP-ribosyl)ation of agmatine by DEA-BAG or the enzyme inhibitors and their I C 50 values for inhibition of receptor-dependent polymerization of cytoskeletal actin and chemotaxis.
4 These results suggest a role for mono(ADP-ribosyl)transferase in the transduction pathway involved in receptor-dependent re-alignment of the cytoskeleton during neutrophil chemotaxis. 相似文献
2 A panel of inhibitors of mono(ADP-ribosyl)transferase (including vitamins K
3 There was a close linear correlation between the I C
4 These results suggest a role for mono(ADP-ribosyl)transferase in the transduction pathway involved in receptor-dependent re-alignment of the cytoskeleton during neutrophil chemotaxis. 相似文献
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GERALD E. PIÉRARD M.D. Ph .D. JORGE E. ARRESE M.D. AFSHIN DOWLATI M.D. PANAGIOTIS A. DASKALEROS Ph .D. CARLOS RODRIGUEZ Ph .D. 《International journal of dermatology》1994,33(2):138-141
Background. The effects of softened and unsoftened fabrics on the skin of infants of 1–12 months of age were evaluated under real life conditions of skin contact with fabrics. Methods. During 4 weeks, 24 infants wore cotton fabrics washed with a granular detergent on one side of their lower back, and on the other side, cotton fabrics washed with the same detergent and softened with a liquid fabric softener. Skin effects were evaluated by visual grading for redness, dryness, and smoothness, by skin stripping and measuring of Chroma C* (squamometry), by measurements of elasticity and bioelastic ratio, and by instrumental measurements of skin parameters (pH, capacitance, transepidermal water loss (TEWL), and erythema by colorimetry). Results. No deleterious effects were observed in any infant. A decrease in squamometry (Chroma C*) and an increase in capacitance were detected in skin exposed to softened fabrics relative to unsoftened ones. Values of pH tended to be higher in the sites treated with softened versus unsoftened fabrics (pH 6.06 and 5.87, respectively, at end of study). All other parameters showed no significant differences in the two treatment groups. Conclusions. Neither softened nor unsoftened fabrics produced any adverse effects on the skin of infants after continuous wearing during 29 days. A slight beneficial effect on the infants' skin was observed with softened relative to unsoftened fabrics. Methods measuring the structure and function of the stratum corneum were more sensitive discriminators of the effects of fabrics on the skin than traditional methods of visual clinical evaluation. 相似文献
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MICHAEL EFREMIDIS M.D. KONSTANTINOS P. LETSAS M.D. LOUIZA LIONI M.D. GEORGIOS GIANNOPOULOS M.D. PANAGIOTIS KORANTZOPOULOS M.D. KONSTANTINOS VLACHOS M.D. NIKOLAOS P. DIMOPOULOS M.D. DIMITRIOS KARLIS M.D. GEORGIOS BOURAS M.D. ANTONIOS SIDERIS M.D. SPYRIDON DEFTEREOS M.D. 《Pacing and clinical electrophysiology : PACE》2014,37(6):703-711
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JOHN CHILADAKIS M.D. F.E.S.C. ANDREAS KALOGEROPOULOS M.D. PANAGIOTIS ARVANITIS M.D. NIKOLAOS KOUTSOGIANNIS M.D. FANI ZAGLI M.D. DIMITRIOS ALEXOPOULOS M.D. F.E.S.C. F.A.C.C. 《Journal of cardiovascular electrophysiology》2010,21(8):905-913
Drug‐Induced QTc Interval Assessment. Introduction: There is debate on the optimal QT correction method to determine the degree of the drug‐induced QT interval prolongation in relation to heart rate (ΔQTc). Methods: Forty‐one patients (71 ± 10 years) without significant heart disease who had baseline normal QT interval with narrow QRS complexes and had been implanted with dual‐chamber pacemakers were subsequently started on antiarrhythmic drug therapy. The QTc formulas of Bazett, Fridericia, Framingham, Hodges, and Nomogram were applied to assess the effect of heart rate (baseline, atrial pacing at 60 beats/min, 80 beats/min, and 100 beats/min) on the derived ΔQTc (QTc before and during antiarrhythmic therapy). Results: Drug treatment reduced the heart rate (P < 0.001) and increased the QT interval (P < 0.001). The heart rate increase shortened the QT interval (P < 0.001) and prolonged the QTc interval (P < 0.001) by the use of all correction formulas before and during antiarrhythmic therapy. All formulas gave at 60 beats/min similar ΔQTc of 43 ± 28 ms. At heart rates slower than 60 beats/min, the Bazett and Framingham methods provided the most underestimated ΔQTc values (14 ± 32 ms and 18 ± 34 ms, respectively). At heart rates faster than 60 beats/min, the Bazett and Fridericia methods yielded the most overestimated ΔQTc values, whereas the other 3 formulas gave similar ΔQTc increases of 32 ± 28 ms. Conclusions: Bazett's formula should be avoided to assess ΔQTc at heart rates distant from 60 beats/min. The Hodges formula followed by the Nomogram method seem most appropriate in assessing ΔQTc. (J Cardiovasc Electrophysiol, Vol. 21, pp. 905‐913, August 2010) 相似文献
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CALAMBUR NARASIMHAN PANAGIOTIS TH. PANOTOPOULOS SANJAY DESHPANDE MOHAMMAD R. JAZAYERI ANWER DHALA ZALMEN BLANCK MASOOD AKHTAR JASBIR SRA 《Pacing and clinical electrophysiology : PACE》1999,22(1):60-64
The effect of initial phase polarity (IPP) reversal using biphasic shocks on DFT at the time of implantation of implantable cardioverter defibrillator and the reproducibility of this effect during predischarge testing was evaluated in a randomized fashion. Twenty-two patients with ventricular tachycardia or ventricular fibrillation (VF) who received either the Medtronic 7219D (7 patients), 7219C (12 patients), 7223 (1 patient), or CPI Ventak MINI (2 patients) were studied. The DFT was determined in a randomized fashion at implantation and during predischarge testing using a binary search protocol. Initial shock was delivered at 12 J. If successful, subsequent shock was delivered at 6 J, following which the shock was incremented or decremented by 3 J depending upon the success. The DFT for right ventricular (RV)-and RV + IPP was 10.9 ± 4.1 J and 11.1 ± 4.0 J, respectively, at implant (P = ns) and 9.7 ± 4.3 J and 8.4 ± 6 J, respectively, (P = ns) at predischarge testing. Of the six patients who had better DFT with RV+ at implantation, only one patient maintained the benefit during predischarge testing. The differences observed in IPP in individual patients may not be demonstrable during repeated testing. These findings may have implications on how these devices should be programmed. 相似文献
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LOUKAS KAKLAMANIS ADRIAN SAVAGE NEIL MORTENSEN PANAGIOTIS TSIOTOS IPATIA DOUSSIS-ANAGNOSTOPOULOU SIMON BIDDOLPH RUTH WHITEHOUSE ADRIAN L. HARRIS KEVIN C. GATTER 《The Journal of pathology》1996,179(1):10-14
bcl-2 was originally identified as an oncogene involved in follicular lymphomas as a result of chromosomal translocation (14;18). It is now believed that bcl-2 is implicated in the regulation of cell death by inhibiting apoptosis and that its expression is not restricted to haematopoietic cells, but is also present in many epithelia and mesenchymal tissues. Recent studies have analysed the expression of this molecule in a variety of non-lymphoid malignancies including lung, breast, prostate, and nasopharyngeal carcinomas and neuroblastoma. In the present study, 50 colorectal adenomas, 10 hyperplastic polyps, and 142 carcinomas, including 25 arising from pre-existing adenomas, were examined using an antibody detecting the bcl-2 protein product. In non-neoplastic mucosa, bcl-2 was expressed in the crypt cells only, whilst the more differentiated surface epithelial cells lacked any demonstrable bcl-2. Forty-one of the 50 adenomas (82 per cent) and 48 of the 142 carcinomas were positive for bcl-2 expression. All hyperplastic polyps were negative. A reciprocal relationship was found between bcl-2 reactivity and p53 overexpression, as detected by DO7 antibody, in approximately 65 per cent of the cases. The bcl-2-positive/p53-negative subgroup showed a strong correlation ( P =0·0056) with negative lymph node status (Dukes' A and B), implying a less aggressive pathway of neoplastic transformation. 相似文献