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排序方式: 共有1430条查询结果,搜索用时 15 毫秒
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Dorota Gabry's Annegret Dörfler Ala Yaromina Franziska Hessel Mechthild Krause Reinhard Oertel Prof. Dr. Michael Baumann 《Strahlentherapie und Onkologie》2008,184(1):48-53
PURPOSE: To evaluate the effect of lovastatin alone or combined with radiation on U87MG and FaDu cells in vitro and U87MG tumors in vivo. MATERIAL AND METHODS: Cell number, p21(WAF1) expression, apoptosis, reproductive cell death, and cell-cycle distribution were investigated after incubation of U87MG and FaDu cells in vitro. The effect of lovastatin (50 mg/kg/day) on tumor growth and on tumor growth delay after single-dose irradiation with 20 Gy was investigated using U87MG tumors in nude mice. RESULTS: Lovastatin dose dependently decreased cell number and proliferation of U87MG and FaDu cells. The proportion of cells in G0/G1 phase, apoptosis and p21 protein expression increased after lovastatin alone or combined with 4-Gy irradiation in both cell lines. Effects of lovastatin on cell cycle and cell number were more pronounced in U87MG compared to FaDu. No radiosensitization of clonogenic cells by lovastatin could be demonstrated in both cells lines, but the colony-forming ability after lovastatin alone was decreased in FaDu cells. In vivo, lovastatin decreased tumor volume over time but did not increase growth delay after irradiation of U87MG tumors with 20 Gy. CONCLUSION: The data support effects of lovastatin on proliferation, apoptosis and colony-forming ability in vitro and tumor volume in vivo. At the drug concentration achievable, lovastatin did not improve the effects of radiation on U87MG tumors in vivo. 相似文献
4.
Wolfgang H Oertel Tobias W?chter Niall P Quinn Gudrun Ulm Dirk Brandst?dter 《Movement disorders》2003,18(4):430-432
According to the consensus statement on the diagnosis of multiple system atrophy (MSA), erectile dysfunction is required for male patients to fulfil the urinary incontinence criterion. However, there is no equivalent item for female patients. We questioned 19 female patients with MSA of the parkinsonian type (MSA-P), 28 female patients with Parkinson's disease (PD), and 27 healthy controls on their genital sensitivity. A total of 47% of the MSA patients but only 4% of the PD patients and 4% of the control group admitted to reduced genital sensitivity, a highly significant difference (P < 0.001). Moreover, the appearance of reduced genital sensitivity in female MSA patients showed a close temporal relation to the onset of the disease. If these preliminary results can be confirmed and further specified in a larger sample, a historical item of reduced genital sensitivity in female patients might become a diagnostic feature for MSA, comparable to erectile dysfunction in male patients. 相似文献
5.
Sigrid C. Schwarz Hansjörg Sauer Wolfgang H. Oertel Christopher D. Earl Andreas R. Kupsch 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》1997,115(1):71-82
We employed intracerebral co-transplantation of foetal xenogeneic striatal mouse tissue and allogeneic rat substantia nigra
into the adult rat brain to elucidate the effects of xenogeneic mouse graft on the function and survival of an allogeneic
rat graft in 6-hydroxydopamine lesioned Sprague-Dawley rats. Foetal mouse striatum (STR) and rat substantia nigra (VM) were
transplanted as non-pooled separate deposits or a pooled cell suspension with or without cyclosporin A (Cy A). Immunosuppressed
recipients of pooled rat and mouse co-grafts showed a significantly better compensation of amphetamine-induced rotational
behaviour compared with non-immunosuppressed animals with pooled rat and mouse co-grafts 3 and 6 weeks post-grafting.Tyrosine
hydroxylase (TH) immunohistochemistry revealed a non-significant reduction in survival in pooled (1806.3±367.5 cells) rat
and mouse co-transplants without immunosuppression compared with immunosuppressed pooled (3383.3±732.7 cells) animals with
allo- and xenogeneic tissue and controls (3506.4±839.3 cells). Graft volumes were significantly reduced in pooled transplants
without immunosuppression (0.1±0.026 mm3; ANOVA post-hoc SchefféF-test, P<0.0001) compared with immunosuppressed recipients (0.7±0.1 mm3) and controls (0.6±0.1 mm3). In non-pooled allo- and xenogeneic grafts without immunosuppression the survival rate of the TH-immunoreactive cells and
graft volumes were reduced (2359.3±479.5 cells; 0.2±0.043 mm3) compared with immunosuppressed animals (2927.3±946.6 cells; 0.6±0.2 mm3) and controls (2701.1±693.8 cells; 0.3±0.1 mm3) without reaching a level of significance. Rejection of mouse tissue was observed in all non-immunosuppressed recipients.
In summary: (i) continued immunosuppression yielded significant beneficial effects on function and beneficial effects on survival
of pooled grafts with an immunogenetic disparity; (ii) the rejection of a xenogeneic graft component may compromise survival
and function of other, allogeneic graft components; and (iii) transplantation of non-pooled allo- and xenogeneic tissues may
result in a better survival of the graft compared with pooled cell suspensions.
Received: 25 March 1996 / Accepted: 1 December 1996 相似文献
6.
Christoph Scherfler MD Johannes Schwarz MD PhD Angelo Antonini MD PhD Donald Grosset MD Francesc Valldeoriola MD PhD Kenneth Marek MD Wolfgang Oertel MD Eduardo Tolosa MD PhD Andrew J. Lees MD Werner Poewe MD 《Movement disorders》2007,22(9):1229-1238
The diagnosis of idiopathic Parkinson's disease (PD) can be achieved with high degrees of accuracy in cases with full expression of classical clinical features. However, diagnostic uncertainty remains in early disease with subtle or ambiguous signs. Functional imaging has been suggested to increase the diagnostic yield in parkinsonian syndromes with uncertain clinical classification. Loss of striatal dopamine nerve terminal function, a hallmark of neurodegenerative Parkinsonism, is strongly related to decreases of dopamine transporter (DAT) density, which can be measured by single photon emission computed tomography (SPECT). The use of DAT‐SPECT facilitates the differential diagnosis in patients with isolated tremor symptoms not fulfilling PD or essential tremor criteria, drug‐induced, psychogenic and vascular Parkinsonism as well as dementia when associated with Parkinsonism. This review addresses the value of DAT‐SPECT in early differential diagnosis, and its potential as a screening tool for subjects at risk of developing PD as well as issues around the assessment of disease progression. © 2007 Movement Disorder Society 相似文献
7.
Topographic association between active gastritis and Campylobacter pylori colonisation. 总被引:13,自引:3,他引:13 下载免费PDF全文
E Bayerd?rffer H Oertel N Lehn G Kasper G A Mannes T Sauerbruch M Stolte 《Journal of clinical pathology》1989,42(8):834-839
One thousand biopsy specimens obtained from 10 sites in the stomachs of 50 patients were examined for the presence of active chronic gastritis and Campylobacter pylori. All 32 patients with active chronic gastritis at 234 out of 320 sites were positive for C pylori: 227 showed colonisation with C pylori by the Warthin-Starry stain; and 222 were positive by culture. C pylori was not found in 18 patients with inactive chronic gastritis or histologically normal mucosa. The area of C pylori colonisation was larger than the area of active chronic gastritis in 289 positive specimens on culture and 261 on staining, respectively, suggesting that C pylori colonisation may precede the development of active chronic gastritis. It is concluded that patchy distribution of active chronic gastritis and C pylori colonisation must be considered, particularly in serology or breath test studies where the histological examination serves as a reference. Furthermore, it may have important implications for the follow up of patients after antibacterial treatment. The topographic and specific association of C pylori and active chronic gastritis provides further evidence for the pathogenic role of C pylori in active chronic gastritis. 相似文献
8.
The immunoperoxidase-antiperoxidase method (PAP) was combined with immunofluorescence for simultaneous localization of glutamate decarboxylase (GAD)-and somatostatin-like immunoreactivity in rat hippocampal neurons growing in dissociated cell culture. A subpopulation of GAD-immunoreactive neurons additionally exhibited somatostatin-like immunostaining. GAD-negative somatostatin-positive cells could not be observed. It is discussed whether the cultured somatostatin-containing GAD neurons correspond to a certain subclass of basket cells as they occur in situ. 相似文献
9.
Georg W. Oertel 《Journal of molecular medicine (Berlin, Germany)》1961,39(9):492-493
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