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Objective and design: The present study examined effectiveness of low-dose doxycycline (LDD) in combination with nonsurgical therapy on gingival
crevicular fluid (GCF) tissue plasminogen activator (t-PA) levels and clinical parameters in chronic periodontitis (CP) a
over 12-month period.
Methods: GCF samples were collected, probing depth (PD), clinical attachment level (CAL), gingival index (GI) and plaque index were
recorded at baseline, 3, 6, 9 and 12 months. CP patients (n = 65) were randomized to LDD or placebo groups. LDD group received
LDD (20 mg) b.i.d for 3-months plus and root planing (SRP), while placebo group was given placebo capsules b.i.d for 3-months
plus SRP. GCF t-PA levels were determined by ELISA. Friedman, Wilcoxon and Mann-Whitney test was used for statistical analysis.
Results: Significant improvement was observed in all clinical parameters in both groups over 12-month period (p < 0.01). LDD group
had lower PD, CAL and GI scores than placebo group at 6, 9 and 12-months (p < 0.05). GCF t-PA levels reduced in both groups
over 12-month period (p < 0.01). LDD group had lower GCF t-PA levels than placebo group at 6 and 9-months (p < 0.05).
Conclusions: These results provide additional information about usefulness of LDD therapy as an adjunct to nonsurgical therapy in long-term
management of periodontitis.
Received 8 May 2006; returned for revision 13 June 2006; accepted by J. Di Battista 12 July 2006 相似文献
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Özışık Pınar Akdemir Özdener Kubilay Murat Ural Berkan Er Uygur Savaş Ali 《Zeitschrift fur Gesundheitswissenschaften》2022,30(6):1431-1440
Journal of Public Health - Because an increasing number of patients travel internationally to seek medical care, Turkey offers comprehensive and outstanding services under extraordinary conditions... 相似文献
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İpek Ulu Yasemin Çekmez Şule Yıldırım Köpük Nida Özer Eser Evrim Yoğurtçuoğlu Pınar Anğın 《The journal of maternal-fetal & neonatal medicine》2019,32(15):2543-2546
Purpose: The aim of the study was to investigate whether maternal serum TSP-1 level was associated with PE.Materials and methods: In our case control study, 84 pregnant women in the third trimester were included. Forty-one of them were healthy and 43 of them were with the diagnosis of PE. The diagnosis was based on the definitions of the National High Blood Pressure Education Program working Group on High Blood Pressure in Pregnancy. Preeclamptic patients were divided into two subgroups as mild and severe. Blood pressure (BP) of pregnant women were obtained in left-side lying position using a mercury sphygmomanometer after at least 10 minutes of rest. Ten milliliters of venous blood was taken from every pregnant women and dispensed into lithium heparin and serum was obtained. Samples were stored at ?80?°C until analyzed. Serum TSP-1 level was measured using enzyme-linked immunosorbent assay (ELISA). All tests were two-tailed and p < .05 was considered to be statistically significant.Results: TSP-1 level was significantly lower in PE group than in controls (p?=?.003). Platelet counts were similar in two groups (p = .26). TSP-1 levels were significantly lower in severe PE than in mild PE cases. According to the subgroup analysis, TSP-1 level was found significantly lower in severe preeclampsia group compared to control group (p = .015).Conclusions: In light of the association between endothelial dysfunction and preeclampsia, we claim that lower levels of TSP-1 which is released mostly from endothelial cells seem to reflect disease severity in PE. Our study reveals that maternal serum TSP-1 levels decrease in pregnant women presenting with PE and TSP-1 may be a new biomarker for the detection of PE and even severity of it. Further studies especially prospective ones with greater numbers of cases are needed. 相似文献
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Joshua I. Breier Duane Dede Kristin Fiano Eileen B. Fennell Laurie Leach Basim Uthman 《Neurocase》2013,19(4):341-345
Abstract A Wada procedure was performed on a bilingual seizure surgery candidate. Immediately after the injection of barbiturate into the right internal carotid artery the patient spontaneously switched from counting in English (the language he indicated that he used most often) to Spanish (the language he learned first). He named in Spanish spontaneously as well. After injection of the left ICA the patient exhibited a global aphasia, with no evidence for differential recovery of language as the aphasia cleared. These observations are discussed in relation to the hypothesis that a language learned later in life may be more likely to be bilaterally represented than the first language learned. 相似文献
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Sixteen polymorphic microsatellite loci are described for Spergularia echinosperma, an endangered plant endemic to Central Europe. Based on 51 individuals, the number of alleles per locus ranged from 2 to 5, and the observed and expected heterozygosities were both 0.00–0.17. The markers can be valuable tool to conservation genetics of this species across its distributional range. 相似文献
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Ibrahim Rencuzogullari Metin Cağdaş Suleyman Karakoyun Yavuz Karabağ Tufan Çınar 《The American journal of emergency medicine》2018,36(9):1722.e1-1722.e3
Venous thrombosis is recognized as one of the most important complications of nephrotic syndrome (NS). In patients with NS, venous thrombosis may develop in the renal veins, the deep veins of the lower limb, and the inferior vena cava. Here, we describe a case report of an NS patient with multiple venous thrombosis in the right renal vein, the left iliac vein, the vena cava inferior, the right atrium, and the pulmonary arteries. Moreover, we describe the successful treatment of multiple venous thrombosis with prolonged thrombolytic treatment in spite of an increased risk of bleeding due to renal biopsy. 相似文献