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排序方式: 共有1328条查询结果,搜索用时 15 毫秒
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Pulina N. A. Kuznetsov A. S. Krasnova A. I. Novikova V. V. 《Pharmaceutical Chemistry Journal》2019,53(3):220-224
Pharmaceutical Chemistry Journal - N-Substituted 4-aryl-2-hydroxy-4-oxobut-2-enoic acid hydrazides and their complexes with Ni(II), Mn(II), Co(II), Cu(II), and Zn(II) were prepared. Their... 相似文献
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A. V. Dolzhenko-Podchezertseva V. V. Novikova L. M. Korkodinova T. F. Odegova 《Pharmaceutical Chemistry Journal》2005,39(1):15-17
Nineteen N-acyl-5-bromanthranilic acid amides were synthesized via acylation of 5-bromanthranilamide with suitable anhydrides. The antimicrobial activity of the synthesized compounds with respect to Staphylococcus aureus and Escherichia coli was evaluated. Compounds with diphenyl, furoyl, and tetrachlorophthalyl moieties in the acyl part of the molecule showed significant inhibition of microbial growth. The minimum inhibiting concentrations of this compounds were 15.6 μg/ml against S. aureus and 15.6 – 31 μg/ml against E. coli. Other tested amides were considerably less active.__________Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 1, pp. 17 – 18, January, 2005. 相似文献
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The role of growth factors and cytokines in the impaired healing of chronic leg ulcers remains uncertain. The aim of this study was to determine whether changes in the amount and location of cytokines and growth factors may be associated with impaired healing in chronic leg ulcers. Biopsies from leg ulcers of 21 patients and from normal skin of nine healthy volunteers were examined immunohistochemically for selected growth factors and cytokines. Greater staining intensity was found in keratinocytes at the edges of ulcers compared to normal skin, or skin adjacent to the ulcers. Staining at the ulcer edge was more intense in nonhealing ulcers for only vascular endothelial growth factor and platelet-derived growth factor, whereas staining in the adjacent skin was more intense for all factors in the nonhealing phase. For all factors staining was cytoplasmic, suggesting production in these areas. This study shows up-regulation of the production of cytokines and growth factors in keratinocytes of chronic leg ulcers that is greater when the ulcers are nonhealing. 相似文献
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153 foetuses were studied obtained after the artificial abortion for genetical indications. The scheme of the material investigation is given. Isolated, systemic and multiple defects were found in 39.0, 12.1 and 48.9%, respectively, and the contribution of the syndrome forms in the multiple developmental disturbances was 60.9%. The interruption of the pregnancy in 2% of cases was assessed as unfounded: as a consequence of hyperdiagnosis and in cases of treatable defects. The frequency of the discrepancy between prenatal and pathology diagnoses was 31.8% including hyperdiagnosis of the defect (1.3%), nosological disagreement (13.3%), the lack of diagnosis of the additional defects detectable during II trimester by present ultrasound methods (17.2%). The efficacy of the work of the prenatal diagnostic centre is, according to the authors, the number of justified interruptions of pregnancy (98% in this study). 相似文献
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N D Novikova M I Orlova M B D'iachenko 《Kosmicheskaia biologiia i aviakosmicheskaia meditsina》1986,20(1):71-73
The main representatives of human auto-microflora were examined to identify the microorganisms that can grow and develop on various polymers used in an enclosed interior. Bacteria of the Genera Pseudomonas, Proteus and Bacillus were found to be most proliferative. Microbial growth was strongly influenced by environmental parameters of the enclosure and by the chemical structure of the polymer. 相似文献
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